A5005170127- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Nutrition and Health in Aging
- MRI in cancer diagnosis
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Cardiac Imaging and Diagnostics
- Frailty in Older Adults
- Renal cell carcinoma treatment
- Cardiac tumors and thrombi
- Neuroendocrine Tumor Research Advances
- Ovarian cancer diagnosis and treatment
- Neuroblastoma Research and Treatments
- CAR-T cell therapy research
- Pancreatitis Pathology and Treatment
- Lung Cancer Research Studies
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Cancer Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Chemotherapy-induced cardiotoxicity and mitigation
- Bladder and Urothelial Cancer Treatments
- Glioma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Medical Imaging Techniques and Applications
Moffitt Cancer Center
2016-2025
Sir Charles Gairdner Hospital
2024
Korea University
2024
Chung-Ang University Hospital
2024
Dunsan Korean Medicine Hospital
2024
University of South Florida
2015-2021
Florida College
2017-2020
University of Florida
2020
Medical Education Institute
2016
University of Wisconsin–Madison
2014-2015
Abstract Background Chimeric antigen receptor T- Cell (CAR-T) immunotherapy has been a breakthrough treatment for various hematological malignancies. However, cardiotoxicities such as new-onset heart failure, arrhythmia, acute coronary syndrome and cardiovascular death occur in 10–15% of patients treated with CAR-T. This study aims to investigate the changes cardiac inflammatory biomarkers CAR-T therapy determine role pro-inflammatory cytokines. Methods In this observational study, ninety...
BACKGROUNDIntraductal papillary mucinous neoplasms (IPMNs) are non-invasive pancreatic precursor lesions that can potentially develop into invasive ductal adenocarcinoma.Currently, the International Consensus Guidelines (ICG) for IPMNs provides basis evaluating suspected on computed tomography (CT) imaging.Despite using ICG, it remains challenging to accurately predict whether harbor high grade or disease which would warrant surgical resection.A supplementary quantitative radiological tool,...
This study's objective was to evaluate the change in sarcopenia score following neoadjuvant chemotherapy (NAC) and correlate both with perioperative outcomes patients advanced resected gastric cancer.Multi-institutional analysis of cancer who underwent NAC resection from 2000-2015 performed. Demographic data were included. Sarcopenia defined as CT measurement total psoas muscle at L3, stratified by height (m). a <385 mm2/m2 women <545 men.Of 36 patients, 19% sarcopenic prior NAC. Following...
Introduction In clear cell renal carcinoma (ccRCC), tumor-associated macrophage (TAM) induction of CD8+T cells into a terminally exhausted state has been implicated as major mechanism immunotherapy resistance, but deeper biological understanding is necessary. Methods Primary ccRCC tumor samples were obtained from 97 patients between 2004 and 2018. Multiplex immunofluorescence using lymphoid myeloid markers was performed in seven regions interest per patient across three predefined zones,...
Introduction Cancer-associated cachexia (CC) is a progressive syndrome characterized by unintentional weight loss, muscle atrophy, fatigue, and poor outcomes that affects most patients with pancreatic ductal adenocarcinoma (PDAC). The ability to identify classify CC stage along its continuum early in the disease process challenging but critical for management. Objectives main objective of this study was determine prevalence overall sex race ethnicity among treatment-naïve PDAC cases using...
Objective The aim of this study was to determine if magnetic resonance imaging (MRI) performed with hepatobiliary phase results in higher lesion conspicuity and produces measurements interobserver agreement than other MRI sequences when neuroendocrine hepatic metastases. Methods Patients who had MRIs both gadoxetate disodium gadopentetate dimeglumine contrast within a 6-month span were identified, 23 lesions selected. Three radiologists 1 oncologist measured the greatest diameter each on...
Pancreatic ductal adenocarcinoma is projected to become the second leading cause of cancer-related deaths by 2040, with highest disease burden expected amongst Non-Hispanic Blacks. One most significant predictors poor outcomes presence cancer-associated cachexia (CCa). Yet, race- and ethnicity-specific biomarkers for early CCa diagnosis are lacking. Thus, evaluated a panel candidate in diverse cohort pre-treatment serum. Our study shows that GDF-15 was associated severity, superior standard...
3 Background: The risk level of lymph node metastasis in penile cancer is determined using the Graafland criteria which determines how patients are treated. These imaging-based have critical implications on patient care yet not been extensively validated. purpose this study was to validate and assess use radiomics analysis CT scans standardize stratification. Methods: Thirty-eight with squamous cell prior regional lymphadenectomy were included retrospective cohort. Patients chemotherapy for...
Penile squamous cell carcinoma is a rare cancer although the incidence varies across globe according to geographic differences in risk factors [1]. The primary site of lymphatic metastatic disease groin and early surgical staging groins offers survival advantage [1, 2]. There are certain histopathological features nodal that indicate high-risk with worse prognosis: extra-nodal tumour extension, three or more unilateral nodes, pelvic lymph node involvement [3, 4]. These patients could benefit...
Abstract Background: Image based body composition is the gold standard for assessing skeletal muscle area and quality in cancer patients. In patients with pancreatic ductal adenocarcinoma (PDAC), decrease can be particularly profound. Yet image-based assessment these may impeded by presence of edema at follow up caused disease burden and/or treatment. Edema superficial affect Hounsfield units surrounding tissue leading to overestimation area. Despite this, our knowledge no studies have...
Cancer cachexia is a common metabolic disorder characterized by severe muscle atrophy which associated with poor prognosis and quality of life. Monitoring skeletal area (SMA) longitudinally through computed tomography (CT) scans, an imaging modality routinely acquired in cancer care, effective way to identify track this condition. However, existing tools often lack full automation exhibit inconsistent accuracy, limiting their potential for integration into clinical workflows. To address...
Pancreatic cancer (PC) is characterized by racial/ethnic disparities and the debilitating muscle-wasting condition, cachexia. Florida ranks second in number of PC deaths has a large understudied minority population. We examined primary hypothesis that incidence mortality rates may be highest among Black Floridians secondary biological correlates cachexia underlie disparities. were estimated race/ethnicity, gender, county using publicly available state-wide registry data included...