A5060799217- Cancer survivorship and care
- Nutrition and Health in Aging
- Childhood Cancer Survivors' Quality of Life
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Adipose Tissue and Metabolism
- Head and Neck Cancer Studies
- Cancer-related cognitive impairment studies
- Frailty in Older Adults
- Cutaneous Melanoma Detection and Management
- CAR-T cell therapy research
- Skin Protection and Aging
- Dysphagia Assessment and Management
- Family and Patient Care in Intensive Care Units
- Diet and metabolism studies
- Behavioral Health and Interventions
- Cancer-related molecular mechanisms research
- Health and Wellbeing Research
- Nutrition, Genetics, and Disease
- Computational Drug Discovery Methods
- Family Support in Illness
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Food Security and Health in Diverse Populations
- Palliative Care and End-of-Life Issues
- Telemedicine and Telehealth Implementation
Moffitt Cancer Center
2021-2025
University of South Florida
2022
University of Illinois Urbana-Champaign
2017-2021
Warrington Hospital
2009
University of Missouri
2004
Introduction Cancer-associated cachexia (CC) is a progressive syndrome characterized by unintentional weight loss, muscle atrophy, fatigue, and poor outcomes that affects most patients with pancreatic ductal adenocarcinoma (PDAC). The ability to identify classify CC stage along its continuum early in the disease process challenging but critical for management. Objectives main objective of this study was determine prevalence overall sex race ethnicity among treatment-naïve PDAC cases using...
Abstract Background: Cancer-related fatigue (CRF) is a prevalent and debilitating symptom among colorectal cancer (CRC) patients. This study aimed to identify genetic variants associated with CRF trajectories assess their relationships clinical demographic factors. Methods: Participants (N=1,219) were recruited from the ColoCare Study across six U.S. sites University of Heidelberg in Germany. Eligible participants adults (≥18 years) new diagnosis primary colon or rectal cancer. was assessed...
Pancreatic ductal adenocarcinoma is projected to become the second leading cause of cancer-related deaths by 2040, with highest disease burden expected amongst Non-Hispanic Blacks. One most significant predictors poor outcomes presence cancer-associated cachexia (CCa). Yet, race- and ethnicity-specific biomarkers for early CCa diagnosis are lacking. Thus, evaluated a panel candidate in diverse cohort pre-treatment serum. Our study shows that GDF-15 was associated severity, superior standard...
Abstract Background: Image based body composition is the gold standard for assessing skeletal muscle area and quality in cancer patients. In patients with pancreatic ductal adenocarcinoma (PDAC), decrease can be particularly profound. Yet image-based assessment these may impeded by presence of edema at follow up caused disease burden and/or treatment. Edema superficial affect Hounsfield units surrounding tissue leading to overestimation area. Despite this, our knowledge no studies have...
Clinical features may be used to determine which patients with suspected acute coronary syndrome (ACS), but a normal or non-diagnostic ECG, should selected for further investigation inpatient care. We aimed measure the diagnostic value of clinical ACS.Standardised data relating presenting characteristics, associated and risk factors were collected at seven chest pain units established ESCAPE trial. All received troponin measurement least 6 h after last significant symptoms, creatine kinase...
Abstract Survivors of head and neck squamous cell cancers (HNSCC) frequently complain taste dysfunction long after radiation therapy is completed, which contradicts findings from most sensory evaluation studies that predict should resolve few months treatment. Therefore, it remains unclear whether smell function fully recovers in HNSCC survivors. We evaluated survivors (n = 40; age 63 ± 12 years, mean standard deviation) who received between 6 10 years before recruitment compared their...
Objective: The purpose of this qualitative study was to compare the lived experiences among extended (one year or less post-treatment) and long-term (three years more young adult (YA) cancer survivors (ages 18–39 old). Methods: Two trained researchers conducted semi-structured interviews inquiring about overall experience N = 24 YA (n 12 n long-term). same two independently completed line-by-line coding thematic content analysis. Results: Interviews lasted an average 41 min revealed common...
Abstract Background Risk factors for cancer-related fatigue are understudied in colorectal cancer. Purpose This study aimed to address this critical gap the literature by (a) describing changes and health behavior (physical activity, sleep problems) (b) examining if physical activity problems predict trajectories from baseline (approximately at time of diagnosis), 6- 12 months after enrollment. Methods Patients participating international ColoCare Study completed self-report measures 6-,...
To characterize dietary patterns and examine associations with cross-sectional longitudinal changes in quality of life (QOL) over approximately one year after colorectal cancer (CRC) diagnosis.
As a result of tumor location and treatment that is aggressive, head neck cancer (HNC) survivors experience an array symptoms impacting the ability desire to eat termed nutrition impact (NISs). Despite increasing survival time, majority research studies examining NISs have been based on clinical samples HNC patients during acute phase treatment. are often chronic persist beyond completion or may develop as late side effects. Therefore, our team examined NIS complications survivors'...
Abstract Background Inflammation has been associated with higher rates of recurrence and mortality in head neck cancer (HNC). While the biological mechanisms predisposing patients to heightened inflammatory states remain largely unknown, DNA methylation proposed reflect systemic inflammation. In this analysis, we attempt identify meaningful epigenetic patterns HNC survivors by stratifying individuals based on profiles leukocytes. Results We used hierarchical clustering uncover three distinct...