A5083097413- Telomeres, Telomerase, and Senescence
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Cardiac Fibrosis and Remodeling
- Congenital heart defects research
- Mitochondrial Function and Pathology
- Cardiac Ischemia and Reperfusion
- Cardiac Arrhythmias and Treatments
- MicroRNA in disease regulation
- Atrial Fibrillation Management and Outcomes
- Biochemical effects in animals
- CCD and CMOS Imaging Sensors
- Venous Thromboembolism Diagnosis and Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Nitric Oxide and Endothelin Effects
- Atherosclerosis and Cardiovascular Diseases
- Gastroesophageal reflux and treatments
- Calpain Protease Function and Regulation
- CRISPR and Genetic Engineering
- Dysphagia Assessment and Management
- Cardiovascular Health and Risk Factors
- Advanced biosensing and bioanalysis techniques
- Muscle Physiology and Disorders
Newcastle University
2018-2023
University of Newcastle Australia
2023
Centre for Life
2018
à la diffusion de documents scientifiques niveau recherche, publiés ou non, émanant des établissements d'enseignement et recherche français étrangers, laboratoires publics privés.
Abstract Cardiovascular disease is the leading cause of death in individuals over 60 years old. Aging associated with an increased prevalence coronary artery and a poorer prognosis following acute myocardial infarction (MI). With age, senescent cells accumulate tissues, including heart, contribute to age‐related pathologies. However, role senescence recovery MI has not been investigated. In this study, we demonstrate that treatment aged mice senolytic drug, navitoclax, eliminates...
Abstract A key component of cardiac ischemia–reperfusion injury (IRI) is the increased generation reactive oxygen species, leading to enhanced inflammation and tissue dysfunction in patients following intervention for myocardial infarction. In this study, we hypothesized that oxidative stress, due ischemia–reperfusion, induces senescence which contributes pathophysiology IRI. We demonstrate IRI cellular both cardiomyocytes interstitial cell populations treatment with senolytic drug...
Abstract Myocardial infarction is a leading cause of morbidity and mortality. While reperfusion now standard therapy, pathological remodelling to heart failure remains clinical problem. Cellular senescence has been shown contribute disease pathophysiology treatment with the senolytic navitoclax attenuates inflammation, reduces adverse myocardial results in improved functional recovery. However, it unclear which senescent cell populations these processes. To identify whether cardiomyocytes...
Atherosclerosis is an age-related disease characterized by systemic oxidative stress and low-grade inflammation. The role of telomerase telomere length in atherogenesis remains contentious. Short telomeres peripheral leukocytes are predictive for coronary artery disease. Conversely, attenuated has been demonstrated to be protective atherosclerosis. Hence, a potential causative critically debated.In this study, we used multiple mouse models investigate the regulation under as well its impact...
After MDT work-up and review, gastro-oesophageal reflux pulmonary aspiration were found to be common in IPF patients; surgery was recommended only 10% http://ow.ly/rO3T30lU17o.
Abstract Ageing is the biggest risk factor for cardiovascular health and associated with increased incidence of disease. Cellular senescence, a process driven in part by telomere shortening, has been implicated age-related tissue dysfunction. Here, we address question how senescence induced rarely dividing/post-mitotic cardiomyocytes investigate if clearance senescent cells attenuates age related cardiac During ageing, human murine acquire senescent-like phenotype characterised persistent...
Myocardial infarction is a leading cause of morbidity and mortality. While reperfusion now standard therapy, pathological remodeling to heart failure remains clinical problem. Cellular senescence has been shown contribute disease pathophysiology treatment with the senolytic navitoclax attenuates inflammation, reduces adverse myocardial results in improved functional recovery. However, it unclear which senescent cell populations these processes. To identify whether cardiomyocytes...
Abstract A key component of cardiac ischemia-reperfusion injury (IRI) is the increased generation reactive oxygen species, leading to enhanced inflammation and tissue dysfunction in patients following intervention for myocardial infarction. In this study we hypothesized that oxidative stress, due ischemia-reperfusion, induces senescence which contributes pathophysiology IRI. We demonstrate IRI cellular both cardiomyocytes interstitial cell populations treatment with senolytic drug navitoclax...
Background: Irrigated radiofrequency lesions show a "teardrop" shape, due to endocardial sparing, requiring extensive lesion overlap for contiguity at the surface. The effect of dynamic irrigation rate on lesion-shape has not been studied.Objective: To assess if flowrate during ablation optimises shape by minimising sparing. Methods:Ex vivo porcine heart model (Phase 1), irrigated were performed in ventricular tissue 30W with 5 different protocols A) fixed-rate; B) continuous-reduction; C)...
<h3>Introduction</h3> Myocardial infarction is a leading cause of morbidity and mortality. While reperfusion now standard therapy, pathological remodelling to heart failure remains clinical problem. Independent studies have demonstrated that following myocardial multiple cell lineages, including cardiomyocytes, accumulate senescent phenotype. Treatment with the senolytic compound navitoclax has been shown eliminate cells attenuate inflammation, reduce adverse improve functional recovery,...
Ageing is the biggest risk factor for impaired cardiovascular health, disease being leading cause of death in 40% individuals over 65 years old. associated not only with an increased prevalence but also a poorer prognosis, including mortality or incidence heart failure after myocardial infarction (MI). We have demonstrated that aged (23 month old) mice accumulation cardiomyocyte senescence, reduced regenerative potential and display as well recovery following MI. Cellular senescence defined...
<h3>Introduction</h3> Myocardial infarction (MI) is a prominent cause of morbidity and mortality globally. While reperfusion via primary percutaneous coronary intervention the gold-standard therapy, it can lead to phenomenon ischemia-reperfusion injury (IRI), characterised by progressive remodelling heart failure. Little understood regarding mechanisms driving IRI, however, increased oxidative stress known play role. Our previous studies demonstrate that during ageing drives telomere...
Abstract Funding Acknowledgements Investigator Sponsored Research grant from Boston Scientific Introduction Irrigated catheters are the standard tool for radiofrequency (RF) ablation in left atrium and ventricles. However, pathological studies of irrigated RF lesions show a "tear-drop" shape, with widest diameter some depth below endocardial surface relative sparing. This requires overlap to achieve contiguity at surface. There has been little investigation into effect altering irrigation...