A5045531136- Telomeres, Telomerase, and Senescence
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer therapeutics and mechanisms
- Mitochondrial Function and Pathology
- Genetics, Aging, and Longevity in Model Organisms
- Cardiac Fibrosis and Remodeling
- interferon and immune responses
- Advanced NMR Techniques and Applications
- ATP Synthase and ATPases Research
- Ubiquitin and proteasome pathways
- CRISPR and Genetic Engineering
- Cardiac Ischemia and Reperfusion
- Calpain Protease Function and Regulation
- Cardiovascular Function and Risk Factors
- Myasthenia Gravis and Thymoma
- Metabolism and Genetic Disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Cutaneous lymphoproliferative disorders research
- Retinal Development and Disorders
- Circadian rhythm and melatonin
- Adipose Tissue and Metabolism
- Autoimmune and Inflammatory Disorders
- RNA regulation and disease
- Emergency and Acute Care Studies
- Cytomegalovirus and herpesvirus research
Newcastle University
2018-2024
Newcastle Hospitals - Campus for Ageing and Vitality
2018-2024
Wellcome Centre for Mitochondrial Research
2020-2022
Ochsner Medical Center
2005
Imperial College London
1999
Augusta University
1988
Oak Ridge National Laboratory
1985
George Washington University
1954
à la diffusion de documents scientifiques niveau recherche, publiés ou non, émanant des établissements d'enseignement et recherche français étrangers, laboratoires publics privés.
Abstract Senescent cells drive age-related tissue dysfunction partially through the induction of a chronic senescence-associated secretory phenotype (SASP) 1 . Mitochondria are major regulators SASP; however, underlying mechanisms have not been elucidated 2 often essential for apoptosis, cell fate distinct from cellular senescence. During widespread mitochondrial outer membrane permeabilization (MOMP) commits to die 3 Here we find that MOMP occurring in subset mitochondria is feature This...
Article25 March 2021Open Access Source DataTransparent process Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner Anthony Lagnado Department of Physiology Biomedical Engineering, Mayo Clinic, Rochester, MN, USA Robert Arlene Kogod Center on Aging, Search for more papers by this author Jack Leslie Newcastle Fibrosis Research Group, Biosciences Institute, University, upon Tyne, UK Marie-Helene Ruchaud-Sparagano Translational Stella Victorelli Petra Hirsova...
Abstract A key component of cardiac ischemia–reperfusion injury (IRI) is the increased generation reactive oxygen species, leading to enhanced inflammation and tissue dysfunction in patients following intervention for myocardial infarction. In this study, we hypothesized that oxidative stress, due ischemia–reperfusion, induces senescence which contributes pathophysiology IRI. We demonstrate IRI cellular both cardiomyocytes interstitial cell populations treatment with senolytic drug...
Increased activation of the major pro-inflammatory NF-κB pathway leads to numerous age-related diseases, including chronic liver disease (CLD). Rapamycin, an inhibitor mTOR, extends lifespan and healthspan, potentially via suppression inflammaging, a process which is partially dependent on signalling. However, it unknown if rapamycin has beneficial effects in context compromised signalling, such as that occurs several diseases. In this study, we investigated whether could ameliorate...
Left ventricular hypertrophy (LVH) is more prevalent in black than white hypertensives, but this difference greater when identified by electrocardiography (ECG) echocardiography. We evaluated the proposal that current ECG criteria for LVH are less specific, and therefore, useful, blacks whites. In a retrospective cross-sectional study, 408 subjects (271 white, 137 black) referred to hypertension clinic assessment of underwent measurement blood pressure, voltages (Sokolow-Lyon Cornell...
Abstract Genetic processes require the activity of multiple topoisomerases, essential enzymes that remove topological tension and intermolecular linkages in DNA. We have investigated subcellular localisation six human topoisomerases with a view to understanding maintenance mitochondrial Our results indicate mitochondria contain two TOP1MT TOP3A. Using molecular, genomic biochemical methods we find both proteins contribute mtDNA replication, addition decatenation role TOP3A, is stimulated by...
Abstract Ageing is the biggest risk factor for cardiovascular health and associated with increased incidence of disease. Cellular senescence, a process driven in part by telomere shortening, has been implicated age-related tissue dysfunction. Here, we address question how senescence induced rarely dividing/post-mitotic cardiomyocytes investigate if clearance senescent cells attenuates age related cardiac During ageing, human murine acquire senescent-like phenotype characterised persistent...
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Abstract Senescent cells drive age-related tissue dysfunction partially via the induction of a chronic senescence-associated secretory phenotype (SASP). Mitochondria are major regulators SASP; however, underlying mechanisms have not been elucidated. also control apoptosis, cell fate generally perceived as distinct from cellular senescence, which is apoptosis resistant. Here, we show that mitochondrial outer membrane permeability (MOMP) occurring in small subset mitochondria feature...
Abstract A key component of cardiac ischemia-reperfusion injury (IRI) is the increased generation reactive oxygen species, leading to enhanced inflammation and tissue dysfunction in patients following intervention for myocardial infarction. In this study we hypothesized that oxidative stress, due ischemia-reperfusion, induces senescence which contributes pathophysiology IRI. We demonstrate IRI cellular both cardiomyocytes interstitial cell populations treatment with senolytic drug navitoclax...
The sudden onset of symptomatic hemorrhoid disease in a 43 year old man heralded infrarenal aortic thrombosis after minor fall. He developed classic Leriche Syndrome and required thrombectomy aorto-bifemoral grafting. unusual presentation is explained by the collateral circulation arteriograms demonstrating this point are presented. It was felt that pres ence pre-existing sub-occlusive iliac predisposed patient to successful outcome followed surgical treatment.