A5021460162- Bone health and osteoporosis research
- Atrial Fibrillation Management and Outcomes
- Bone Metabolism and Diseases
- Bone health and treatments
- Cardiac Arrhythmias and Treatments
- Spectroscopy Techniques in Biomedical and Chemical Research
- Health Systems, Economic Evaluations, Quality of Life
- Bone and Dental Protein Studies
- Atomic and Molecular Physics
- Bone Tissue Engineering Materials
- Protein Interaction Studies and Fluorescence Analysis
- Advanced Biosensing Techniques and Applications
- Acute Myocardial Infarction Research
- Cardiac electrophysiology and arrhythmias
- Quantum Chromodynamics and Particle Interactions
- Monoclonal and Polyclonal Antibodies Research
- Tissue Engineering and Regenerative Medicine
- Vitamin D Research Studies
- Nuclear physics research studies
- X-ray Spectroscopy and Fluorescence Analysis
- Antiplatelet Therapy and Cardiovascular Diseases
- Bone and Joint Diseases
- Collagen: Extraction and Characterization
- Calcium Carbonate Crystallization and Inhibition
- Occupational and environmental lung diseases
Liverpool Heart and Chest Hospital
2022
University of Liverpool
2022
Policlinico di Modena
2022
University of Modena and Reggio Emilia
2022
Laboratoire Informatique d'Avignon
2022
Centre Hospitalier Universitaire de Tours
2022
Aalborg University
2022
Hanusch Hospital
2009-2021
Ludwig Boltzmann Institute of Osteology
2009-2021
Carol Davila University of Medicine and Pharmacy
2021
ABSTRACT Bone strength depends on the amount of bone, typically expressed as bone mineral density (BMD), determined by dual-energy X-ray absorptiometry (DXA), and quality. quality is a multifactorial entity including structural material compositional properties. The purpose present study was to examine whether composition properties at actively-forming trabecular surfaces in health are dependent subject age, contrast them with postmenopausal osteoporosis patients. To achieve this, we...
ABSTRACT High bone mass in animals and humans with sclerostin deficiency is associated increased strength, which not the case for all disorders high mineral density, some of are even fragility fractures owing to unfavorable composition. In current study we investigated whether alterations composition may contribute strength characteristics lack sclerostin. We examined cortical Sost-knockout (KO) mice (n = 9, 16 weeks old) sclerosteosis patients (young [4 14 years], n 4 adults [24 43 2) by...
ABSTRACT Osteogenesis imperfecta (OI) is a clinically and genetically heterogeneous connective tissue disorder characterized by bone fragility that arises from decreased mass abnormalities in material quality. OI type I represents the milder form of disease according to original Sillence classification minimal skeletal deformities near-normal stature. Raman microspectroscopy vibrational spectroscopic technique allows determination properties biopsy blocks with spatial resolution ∼1 µm, as...
Fourier transform infrared (FTIR) attenuated total reflection (ATR) spectroscopy is increasingly used for the investigation of processes at or near interfaces. Exposing HSA dissolved in phosphate buffered saline (PBS) to a clean germanium (Ge) multiple internal element (MIRE) led formation stable compact monolayer with surface concentration (5.31 ± 0.49) × 10−12 mol cm−2. Using flow-through cuvette enabled situ monitoring layer preparing and interaction this 5 mM solution cholate PBS. In...
The development and optimization of biomimetic surfaces required for biosensors medical assays are made more efficient by quantitatively monitoring the surface chemical reactions in situ means attenuated total reflection (ATR) FTIR spectroscopy. single-beam-sample-reference (SBSR) ATR, as well modulated excitation (ME), techniques have been applied to get physicochemical information on growth structure layer. SBSR ME methods result optimum background compensation signal-to-noise ratio....
The ability of bone to resist fracture is dependent on the composite nature its mineral and organic matrix content. Teriparatide (TPTD) zoledronic acid (ZOL) are approved anabolic antiresorptive therapies, respectively, reduce risk in women with postmenopausal osteoporosis. In SHOTZ study, osteoporosis were treated TPTD (20 μg daily, subcutaneous) or ZOL (5 mg/year, intravenous infusion) for 24 months. Iliac crest biopsies obtained at 6 months again from approximately one third original...
FTIR ATR spectroscopy is increasingly used for in situ investigations of processes at or near a surface. Particularly when thin layers (biomembranes, monolayers, films) are investigated with respect to surface concentration and molecular structure, very sensitive techniques have be applied order achieve an adequate signal-to-noise ratio. This may lead long measuring times due extended data accumulation averaging. However, this can cause new problems the stability relevant experimental...
We report a 5-year follow-up of 22 consecutive patients, who underwent transconjunctival management their orbital lesions without muscle dissection. The presentation, natural history, management, surgical appraisal the approach and its indications are discussed. At follow-up, 21 patients showed excellent cosmetic functional results. Our experience suggests that this remains useful modality, with good intraoperative visibility minimal postoperative scar formation, for managing selected...
The deposition of extracellular matrix (ECM) produced by osteoblasts is one the first steps in bone formation. Composition and structure ECM influence development strength bone, as well onset its mineralization. Since secreted onto surface where cells attach, Fourier transform infrared (FT-IR) attenuated total reflection (ATR), a sensitive technique, provides useful tool for investigation, instead predominantly detected IR beam. purpose present study was to develop FT-IR ATR technique so...
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Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)