A5070070925- Cardiovascular and exercise physiology
- Heart Rate Variability and Autonomic Control
- Sports Performance and Training
- Non-Invasive Vital Sign Monitoring
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Atherosclerosis and Cardiovascular Diseases
- Obesity and Health Practices
- Health Promotion and Cardiovascular Prevention
- Cardiovascular Disease and Adiposity
- Occupational Health and Performance
- Cerebrovascular and Carotid Artery Diseases
- Long-Term Effects of COVID-19
- Cancer Immunotherapy and Biomarkers
- High Altitude and Hypoxia
- Genetics and Physical Performance
- Optical Imaging and Spectroscopy Techniques
- Muscle metabolism and nutrition
- COVID-19 Clinical Research Studies
- Eating Disorders and Behaviors
- Infection Control and Ventilation
- COVID-19 and healthcare impacts
- Balance, Gait, and Falls Prevention
- Diabetes Management and Research
- Children's Physical and Motor Development
New York University
2023-2024
Syracuse University
2020-2023
University of Connecticut
2017-2022
Queens College, CUNY
2017
Abstract Patients with coronavirus disease 2019 (COVID-19) present increased risk for ischemic cardiovascular complications up to 1 year after infection. Although the systemic inflammatory response severe acute respiratory syndrome 2 (SARS-CoV-2) infection likely contributes this risk, whether SARS-CoV-2 directly infects coronary vasculature and attendant atherosclerotic plaques remains unknown. Here we report that viral RNA is detectable replicates in lesions taken at autopsy from COVID-19...
Immune checkpoint inhibitor (ICI) therapies can increase the risk of cardiovascular events in survivors cancer by worsening atherosclerosis. Here we map expression immune checkpoints (ICs) within human carotid and coronary atherosclerotic plaques, revealing a network cell interactions that ICI treatments unintentionally target arteries. We identify population mature, regulatory CCR7+FSCN1+ dendritic cells, similar to those described tumors, as hub IC-mediated signaling plaques. Additionally,...
Heart rate variability (HRV) measurements via ambulatory monitors have become common. We examined the validity of recording R-R intervals using Polar V800™ compared to 12-lead electrocardiograms (ECG) among middle-aged (44.7±10.1years); overweight obese (29.8±4.3 kg.m-2) adults (n = 25) with hypertension (132.3±12.2/ 84.3±10.2 mmHg). After resting for 5-min in supine position, were simultaneously recorded and ECG. Artifacts present uncorrected (UN) corrected Kubios HRV Premium (ver. 3.2.)...
Down syndrome (Ds) is the most common chromosomal cause of intellectual disability that results from triplication chromosome 21 genes. Individuals with Ds demonstrate cognitive deficits in addition to comorbidities including cardiac defects, pulmonary arterial hypertension (PAH), low blood pressure (BP), and differences autonomic regulation. Many individuals are born heart malformations some can be surgically corrected. Lower BP at rest response exercise other stressors a prevalent feature...
The aim of this study is to compare the effect jogging and core training after supramaximal exercise on recovery. 30 male basketball players (age; 23,57±1,32 years) playing in regional league participated study. Subjects were required visit laboratory 2 occasions, each separated by 3 days for recovery different methods. performed or Wingate Supramaximal Exercise (WSE) order methods (jogging training) was selected randomly prevent an effect. Resting Heart Rate (HR) blood lactic acid (LA)...
COVID-19 patients present higher risk for myocardial infarction (MI), acute coronary syndrome, and stroke up to 1 year after SARS-CoV-2 infection. While the systemic inflammatory response infection likely contributes this increased cardiovascular risk, whether directly infects vasculature attendant atherosclerotic plaques locally promote inflammation remains unknown. Here, we report that viral RNA (vRNA) is detectable replicates in lesions taken at autopsy from with severe COVID-19....
Immune checkpoint inhibitor (ICI) treatment in cancer has been linked to atherosclerotic-related cardiovascular events. While ICIs have shown aggravate atherosclerosis mouse models of plaque progression, these do not reflect the clinical scenario patients with pre-existing under lipid-lowering treatments. To address this, we tested effects PD1 or CTLA4 inhibitors (aPD1 aCTLA4), and their combination + a model halted mimicking standard care Ldlr -/- mice (n=126) were fed western diet (WD) for...
Abstract In previous studies, we found an endothelial nitric oxide synthase gene ( NOS 3 ) variant rs2070744 associated with the ambulatory blood pressure BP response following bouts of moderate and vigorous intensity acute exercise, termed post‐exercise hypotension PEH ). a validation cohort, sequenced exons for associations . Obese (30.9 ± 3.6 kg m −2 African American n = 14) [ AF ] Caucasian 9) adults 42.0 9.8 years hypertension (139.8 10.4/84.6 6.2 mmHg) performed three random...
FURIN is a proprotein convertase subtilisin/kexin enzyme important in pro-renin receptor processing, and (furin, paired basic amino acid cleaving enzyme) variants are involved multiple aspects of blood pressure (BP) regulation. Therefore, we examined associations among the immediate response to bouts aerobic exercise, termed postexercise hypotension (PEH). Obese (30.9 ± 3.6 kg m−2) Black- (n = 14) White- 9) adults 42.0 9.8 year with hypertension (139.8 10.4/84.6 6.2 mmHg) performed three...
Coronavirus 2019 (COVID-19) disease has been a public health emergency of international concern with millions confirmed cases globally. Closed environments reduced ventilation contribute to the spread COVID-19, including superspreading events. Exercising in closed places further increases risk for transmission. Therefore, many fitness facilities were as part mandated shutdowns early pandemic. Evidence-based safety protocols have now emerged and substantially reduce We report three positive...
Immune checkpoint inhibitor (ICI) therapies substantially increase the risk of atherosclerotic cardiovascular events in cancer survivors. Here, we mapped expression immune checkpoints (ICs) within human plaques, unraveling an intricate local network cell-cell interactions context relevant comorbidities like dyslipidemia and diabetes. Our findings identified a population mature, regulatory CCR7 + FSCN1 dendritic cells as pivotal orchestrators IC-mediated signaling murine function akin to...
Because data are scarce, we examined the relationship between postexercise hypotension (PEH) and heart rate variability (HRV) before after aerobic exercise training among adults with hypertension. Participants completed a 12 w program. Before training, they performed peak graded stress test (GEST) nonexercise control (CONTROL) were left attached to an ambulatory BP monitor. Prior CONTROL, HRV was measured supine for 5 min using 12-lead electrocardiogram (ECG). The participants (n = 18)...
Objective: To examine postexercise hypotension (PEH) after a maximal cardiopulmonary stress test (GEST) as well heart rate variability (HRV), surrogate marker of sympathovagal balance, it relates to PEH among career firefighters with hypertension.
In a recent systematic review, we reported evidence that exercise and nutrition professionals stigmatize their patients due to weight in 81% of 31 studies. Being stigmatized is associated with adverse cardiovascular health consequences for unclear reasons; but may be the heightened reactivity accompanies obesity hypertension. PURPOSE: We examined influence two video exposures, one containing scenes stigma (STIGMA) other non-stigmatizing neutral (NEUTRAL) scenes, on assessed by resting...
The interactions between large artery function and neurovascular coupling (NVC) are emerging as important contributors to cognitive health. Women disproportionally affected by Alzheimer's disease related dementia later in life. Understanding correlates of NVC young women may help with preservation health advancing age. To explore the association function, performance women. Vascular measurements were made 61 (21 ± 4 yrs) at rest during a challenge (Stroop task). Transcranial Doppler was used...
Individuals with a history of COVID-19 have vascular dysfunction that has been implicated in reduced exercise capacity. In response to small muscle mass handgrip exercise, individuals blunted vasodilatory and hyperemic response. Whether this is systemic nature unknown. The blood flow heterogenous across limbs modalities. PURPOSE: To determine whether the leg acute large (cycling) lower adults versus without COVID-19. METHODS: Twenty past diagnosis (mean age = 22 ± 4 years, BMI 25 3 kg/m2, n...
Autonomic dysfunction has been associated with cardiovascular disease (CVD)morbidity and mortality, may be prevalent in people living HIV/AIDS (PLWHA). Physical activity (PA) is better autonomic function healthy cardiometabolic populations. However, there are few data on the resting responses to exercise PLWHA. PURPOSE: To determine whether physically active (Act) PLWHA have compared insufficiently (IA) METHODS: 23 participants (13 Active 10 age gender matched IA PLWHA) were recruited....
Furin (paired basic amino acid cleaving enzyme) is a proprotein convertase subtilisin/kexin (PCSK) enzyme and important in pro renin receptor processing. FURIN variants have been identified to be involved multiple aspects of blood pressure (BP) regulation, targeting PCSKs promising future form drug therapy. PURPOSE: To examine the associations among immediate response bouts acute exercise performed at different intensity, termed postexercise hypotension (PEH). METHODS: Obese (30.9+3.6...
Firefighters have a higher than normal prevalence of cardiovascular disease (CVD) and accompanying risk factors such as hypertension. These CVD may increase the sudden cardiac death (SCD), which accounts for 45% all on-duty firefighter deaths. Exercise confers protection against risk, in part due to immediate blood pressure (BP) reductions 5-7 mmHg following exercise, termed postexercise hypotension (PEH). PEH firefighters has not been studied. PURPOSE: To examine after vigorous physical...
Rett syndrome (RTT) is a severe X-linked progressive neurodevelopmental disorder affecting ~1 in 10,000 females. It the second most common genetic cause of cognitive disability girls, after Down syndrome. Girls with this devastating develop relatively normally for 6-18 months, which they undergo period rapid regression. They lose many motor skills, growth their brain slows, and repetitive, autistic behaviors seizures. Autonomic disruptions are leading early death RTT, rescue breathing...