A5085171942- Essential Oils and Antimicrobial Activity
- Bacterial biofilms and quorum sensing
- Antimicrobial Resistance in Staphylococcus
- Phytochemistry and Biological Activities
- Oral microbiology and periodontitis research
- Probiotics and Fermented Foods
- Bee Products Chemical Analysis
- Phytochemistry Medicinal Plant Applications
- Natural Compound Pharmacology Studies
- Immune Response and Inflammation
- Oral Health Pathology and Treatment
- Phytochemistry and Bioactivity Studies
- Natural product bioactivities and synthesis
- Milk Quality and Mastitis in Dairy Cows
- Insect and Pesticide Research
- Gut microbiota and health
- Antibiotic Resistance in Bacteria
- Phytochemicals and Antioxidant Activities
- Reproductive tract infections research
- Medical and Biological Ozone Research
- Synthesis of Organic Compounds
- Biological Activity of Diterpenoids and Biflavonoids
- Marine Sponges and Natural Products
- Fatty Acid Research and Health
- Sesquiterpenes and Asteraceae Studies
Universidade Federal da Bahia
2014-2024
Hospital Ana Nery
2019-2023
Discovery Air (Canada)
2023
Universidade Estadual de Campinas (UNICAMP)
2000-2010
Sociedade Brasileira de Anestesiologia
2004
Hospital de Clínicas da Unicamp
2004
The bark of Mimosa tenuiflora (Willd.) Poiret (Leguminosae family), popularly known as "jurema preta" in Brazil, is used by the population Contendas Sincorá (Bahia State, Brazil) for treatment coughs and wound healing. Thus, aim this study was to evaluate antinociceptive anti-inflammatory activities ethanol extract (EEMT) solvent soluble fractions (hexane—H, DCM—D, EtOAc—E BuOH—B) vivo. Additionally, we synthesized 5,7-dihidroxy-4'-methoxyflavanone (isosakuranetin) isolated compound...
7-Epiclusianone (7-epi), a novel naturally occurring compound isolated from Rheedia brasiliensis, effectively inhibits the synthesis of exopolymers and biofilm formation by Streptococcus mutans. In present study, ability 7-epi, alone or in combination with fluoride (F), to disrupt development pathogenicity S. mutans vivo was examined using rodent model dental caries. Treatment (twice-daily, 60s exposure) 125 ppm F, resulted biofilms less biomass fewer insoluble glucans than did those treated...
Dental caries is a multifactorial chronic-infection disease, which starts with bacterial biofilm formation caused mainly by Streptococcus mutans. The use of probiotics has shown numerous health benefits, including in the fight against oral diseases. Strains Lactobacillus fermentum have already probiotic potential S. mutans, but there are still few studies. Thus, aim our study was to evaluate antimicrobial activity inoculum and metabolites produced L. TcUESC01 mutans UA159. For this, growth...
This study proposes to implement an alternative and effective strategy for local treatment of disease provoked by S. aureus. For the analysis possible anti-inflammatory activity essential oil, after establishing air pouch model, 48 male mice Balb/c were treated, infected, euthanized at 4 8 h. Thus, total differential white blood cells counted in animal's blood, cytokines IL-1β, IL-6, TNF-α titrated using ELISA lavage. Moreover, TNF-α, IL-6 gene expression was analyzed through RT-qPCR array,...
BACKGROUND Sepsis is a set of serious organic manifestations caused by an infection, whose progression culminates in exacerbated inflammation and oxidative stress, poor prognosis, high hospital costs. Antioxidants used against sepsis have been evaluated, including essential oils such as β ‐caryophyllene (BCP), polyunsaturated fatty acids, docosahexaenoic acid (DHA). The aim this study was to evaluate the anti‐inflammatory activity association these two compounds. RESULTS Treatment with...
The aim of this study was to examine the effects 7-epiclusianone, a new prenylated benzophenone isolated from plant Rheedia gardneriana, on some virulence properties Streptococcus mutans associated with biofilm development and acidogenicity. synthesis glucans by glucosyltransferases B (GTF B) C C) markedly reduced 7-epiclusianone showing more than 80% inhibition enzymatic activity at concentration 100 microg mL(-1). Double-reciprocal analysis (Lineweaver-Burk plots) revealed that GTF...
Abstract The antiproliferative activity of two prenylated benzophenones isolated from Rheedia brasiliensis , the triprenylated garciniaphenone and tetraprenylated benzophenone 7‐epiclusianone, was investigated against human cancer cell lines. on melanoma (UACC‐62), breast (MCF‐7), drug‐resistant (NCI‐ADR), lung/non‐small cells (NCI460), ovarian (OVCAR 03), prostate (PC03), kidney (786‐0), lung (NCI‐460) tongue (CRL‐1624 CRL‐1623) determined using spectrophotometric quantification cellular...
Abstract Background Probiotics are important tools in therapies against vaginal infections and can assist traditional antibiotic restoring healthy microbiota. Recent research has shown that microorganisms belonging to the genus Lactobacillus have probiotic potential. Thus, this study evaluated potential vitro properties of three strains Lactiplantibacillus plantarum , isolated during fermentation high-quality cocoa, Gardnerella vaginalis Neisseria gonorrhoeae . Strains were for their...
Inflammation is a complex biological response involving the immune, autonomic, vascular, and somatosensory systems that occurs through synthesis of inflammatory mediators pain induction by activation nociceptors. Staphylococcus aureus, main cause bacteremia, one most common potent causes inflammation in public health, with worse clinical outcomes hospitals. Antioxidant substances have been evaluated as alternative therapeutic analgesics, antioxidants, anti-inflammatory agents, antitumor...
Abstract Methicillin-resistant Staphylococcus aureus (MRSA) is responsible for high morbidity and mortality rates. Citral has been studied in the pharmaceutical industry shown antimicrobial activity. This study aimed to analyze activity of citral inhibiting biofilm formation modulating virulence genes, with ultimate goal finding a strategy treating infections caused by MRSA strains. showed against isolates minimum inhibitory concentration (MIC) values between 5 mg/mL (0.5%) 40 (4%),...
This study investigates the biofilm formation, presence and distribution of virulence genes capacity to induce an inflammatory response in strains Staphylococcus aureus isolated from milk samples Bahia, Brazil. A total 132 raw were collected four dairy farms (designated D) located southwestern municipality Vitória da Conquista, October/2009 September/2010. After processing samples, 94 (71.2%) S. isolates obtained. These subjected antibiogram method MIC (Minimum Inhibitory Concentration). As...
Staphylococcus aureus is a Gram-positive bacterium that considered an important human pathogen. Due to its virulence and ability acquire mechanisms of resistance antibiotics, the clinical severity S. infection driven by inflammatory responses bacteria. Thus, present study aimed investigate modulating role citral in inflammation caused infection. For this, we used isolate obtained from nasal swab sample healthy child attending day-care centre Vitória da Conquista, Bahia, Brazil. The...
The severe side-effects elicited by conventional antibiotic therapy and the recurrence of Bacterial vaginosis-associated bacteria bacterial resistance have led to development novel alternative therapies, among which genital probiotics are widely used. In this study, we aimed evaluate antimicrobial activities Lactobacillus plantarum Lp62 its supernatant against Gardnerella vaginalis, using both in vitro vivo approaches. assays were used viability strain different pH ranges. An assay was...
In recent years, certain Lactobacillus sp. have emerged in health care as an alternative therapy for various diseases. Based on this, this study is aimed at evaluating vitro the potential probiotics of five lactobacilli strains isolated from pulp cupuaçu fruit fermentation against Gardnerella vaginalis and Neisseria gonorrhoeae. Our were classified safe use humans, they tolerant to heat pH. biofilm producers, while hydrophobicity autoaggregation varied 13% 86% 25%, respectively. The...
Abstract This study determines the optimal conditions for ultrasound‐assisted solid‐liquid extraction (UA‐SLE) of total phenolic compounds (TPC) Cenostigma macrophyllum leaves. The experiments were carried out according to three‐level, four‐variable Box‐Behnken design combined with response surface methodology (RSM). Extraction (sonication) time, liquid‐solid ratio, methanol concentration, and ultrasonic power investigated as independent variables obtain TPC. Data fitted a second‐order...