A5076404799- Diabetes Management and Research
- Diabetes and associated disorders
- Obesity, Physical Activity, Diet
- Physical Activity and Health
- Diabetes Management and Education
- Gestational Diabetes Research and Management
- Diabetes Treatment and Management
- Health Promotion and Cardiovascular Prevention
- Bariatric Surgery and Outcomes
- Nutritional Studies and Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer Risks and Factors
- Diet and metabolism studies
- Genetic Associations and Epidemiology
- Pancreatic function and diabetes
- Birth, Development, and Health
- Prostate Cancer Diagnosis and Treatment
- Chronic Disease Management Strategies
- Diet, Metabolism, and Disease
- BRCA gene mutations in cancer
- Mobile Health and mHealth Applications
- Receptor Mechanisms and Signaling
- Genetic and phenotypic traits in livestock
- Pharmacology and Obesity Treatment
- Urological Disorders and Treatments
Jewish General Hospital
2019-2025
McGill University
2019-2025
MRC Epidemiology Unit
2007-2025
University of Cambridge
2025
McGill University Health Centre
2016-2022
Columbia College
2022
OpenBiome
2020
Minnesota Department of Health
2020
Addenbrooke's Hospital
2011
Division of Cancer Epidemiology and Genetics
2008-2010
To accurately examine associations of physical activity (PA) with disease outcomes, a valid method assessing free-living is required. We examined the validity brief PA questionnaire (PAQ) used in European Prospective Investigation into Cancer and Nutrition (EPIC). energy expenditure (PAEE) time spent moderate vigorous (MVPA) was measured 1,941 healthy individuals from 10 countries using individually-calibrated combined heart-rate movement sensing. Participants also completed short EPIC-PAQ,...
DISC1 has been identified as a schizophrenia susceptibility gene based on linkage and SNP association studies clinical data suggesting that risk SNPs impact hippocampal structure function. In cell animal models, C-terminus-truncated disrupts intracellular transport, neural architecture migration, perhaps because it fails to interact with binding partners involved in neuronal differentiation such fasciculation elongation protein zeta-1 (FEZ1), platelet-activating factor acetylhydrolase,...
Background: Physical activity is associated with a variety of health benefits, but the biological mechanisms that explain these associations remain unclear. Metabolomics powerful tool to comprehensively evaluate global metabolic signature physical and helps pinpoint pathways mediate effects activity. There has been limited research on metabolomics habitual activity, no study examined sedentary behaviour different intensities. Methods: In group Chinese adults (N = 277), we used an untargeted...
Abstract Background: Although physical activity has been associated with reduced breast cancer risk, whether this association varies across subtypes or is modified by reproductive and lifestyle factors unclear. Methods: We examined in relation to postmenopausal risk 182,862 U.S. women the NIH-AARP Diet Health Study. Physical was assessed self-report at baseline (1995-1996), 6,609 incident cancers were identified through December 31, 2003. Cox regression used estimate relative (RR) 95%...
To prospectively examine the relation of total, vigorous and non-vigorous physical activity to postmenopausal breast cancer risk.We studied 32,269 women enrolled in Breast Cancer Detection Demonstration Project Follow-up Study. Usual (including household, occupational leisure activities) throughout previous year was assessed at baseline using a self-administered questionnaire. Postmenopausal cases were identified through self-reports, death certificates linkage state registries. A Cox...
Lower maternal insulin sensitivity during pregnancy is associated with greater fetal adiposity. Physical activity can improve sensitivity, but it not known if physical behaviours influence the association of offspring This study aimed to investigate moderating impact on this association. Pregnant women (n = 812) from Gen3G cohort were recruited first trimester and followed until delivery. At (V1) second (V2) hospital visits, staff measured anthropometry, participants reported sleep duration...
Despite strong evidence of an inverse association physical activity with postmenopausal breast cancer risk, whether a certain intensity or time life is most effective for lowering risk not known.In 118,899 women in the prospective NIH-AARP Diet and Health Study, we examined relations light moderate-to-vigorous during four periods ("historical": ages 15-18, 19-29, 35-39 years; "recent": past 10 years) to risk. Physical was assessed by self-report at baseline, 4287 incident cancers were...
Abstract Physical activity has been inconsistently related to total prostate cancer and few studies have examined whether this association varies by disease aggressiveness. We physical in relation total, advanced, fatal the NIH-AARP Diet Health Study. At baseline (1995-1996), 293,902 men ages 50 71 years completed a questionnaire inquiring about current frequency of vigorous exercise at least 20 min duration, as well during adolescence (ages 15-18). used proportional hazards regression...
Observational studies have demonstrated that type 2 diabetes is a stronger risk factor for coronary heart disease (CHD) in women compared with men. However, it not clear whether this reflects sex differential the causal effect of on CHD or results from sex-specific residual confounding.
Abstract BACKGROUND: The relation of physical activity across the lifespan to risk prostate cancer has not been thoroughly investigated, particularly among black men. authors investigated activity, including during different age periods and various intensities, in incidence white men METHODS: In total, 160,006 3671 ages 51 years 72 who were enrolled National Institutes Health‐AARP Diet Health Study reported their time spent per week engaging 15 18 years, 19 29 35 39 past 10 years. Cox...
In large epidemiologic studies, physical activity (PA) is often assessed using PA questionnaires (PAQ). Because available PAQ may not capture the full range of in which urban Chinese adults engage, a was developed for this purpose. We examined validity and 1-yr stability 545 Shanghai adults.The interview-administered twice, approximately 1 yr apart, participants also wore an accelerometer completed PA-log seven consecutive days every 3 months during same year. The intraclass correlation...
A new member of the family G protein‐coupled receptors has been isolated from a rat pituitary cDNA library by polymerase chain reaction (PCR) using degenerate oligonucleotide primers. The corresponding protein sequence shows seven transmembrane domains and contains conserved regions homology characteristic class receptors. novel remptor mRNA is expressed in brain, gland testis, localized situ hybridization discrete brain. Expression receptor Xenopus oocytes transfected mammalian...
Physical inactivity and high mammographic breast density have both been associated with increased cancer risk. However, the association between physical activity remains inconsistent. In European Prospective Investigation of Cancer (EPIC)-Norfolk population-based cohort study (United Kingdom), authors investigated cross-sectional level at baseline during 1993–1997 among 1,394 postmenopausal, cancer-free women. Usual was assessed by a brief, validated questionnaire. Percentage determined...