A5046580630- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Ubiquitin and proteasome pathways
- Cell Adhesion Molecules Research
- Adipose Tissue and Metabolism
- Lipid metabolism and disorders
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Sarcoma Diagnosis and Treatment
- Cancer-related gene regulation
- Chromatin Remodeling and Cancer
- Ear and Head Tumors
- Regulation of Appetite and Obesity
- Glioma Diagnosis and Treatment
- RNA modifications and cancer
- Phytochemicals and Antioxidant Activities
- Signaling Pathways in Disease
- Effects and risks of endocrine disrupting chemicals
- Liver physiology and pathology
- Drug-Induced Hepatotoxicity and Protection
- Drug Transport and Resistance Mechanisms
- Pancreatitis Pathology and Treatment
- Nerve injury and regeneration
- Aldose Reductase and Taurine
- MicroRNA in disease regulation
Bambino Gesù Children's Hospital
2019-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2024
Non-alcoholic fatty liver disease (NAFLD)-related fibrosis results in the encapsulation of injured parenchyma by a collagenous scar mainly imputable to hepatic stellate cells' activation. Approved pharmacological treatments against NAFLD-related are still lacking, but natural compounds such as hydroxytyrosol (HXT) and vitamin E (VitE), emerging promising therapeutic opportunities. In this study, potential anti-fibrotic effect HXT + VitE combination therapy was investigated vitro vivo....
Hepatocellular carcinoma (HCC) is one of the most common and lethal malignant tumours worldwide. Sorafenib (SOR) effective single-drug systemic therapy against advanced HCC, but identification novel combination regimens for a continued improvement in overall survival big challenge. Recent studies highlighted crucial role focal adhesion kinase (FAK) HCC growth. The aim this study was to investigate antitumor effects three different FAK inhibitors (FAKi), alone or with SOR, using vitro vivo...
Nonalcoholic fatty liver disease (NAFLD) has become the most common chronic in children and adolescents, increasing risk of its progression toward nonalcoholic steatohepatitis (NASH), cirrhosis, cancer. There is an urgent need for noninvasive early diagnostic prognostic tools such as epigenetic marks (epimarks), which would replace biopsy future. We used plasma samples from 67 with biopsy-proven NAFLD, controls we 20 negative steatosis by ultrasound. All patients were genotyped patatin-like...
The SARS-CoV-2 pandemic has caused approximately 6.3 million deaths, mainly due to the acute respiratory distress syndrome or multi-organ failure that characterizes COVID-19 disease. Post-acute syndrome, also known as long-COVID, is a condition characterized by complex of symptoms affects 10–20% individuals who have recovered from infection. Scientific and clinical evidence demonstrates long-COVID can develop in both adults children. It been hypothesized effects could be associated with...
Post-translational modulation of peptidylprolyl isomerase Pin1 might link impaired glucose metabolism and neurodegeneration, being effectors target for the glucagon-Like-Peptide1 analog liraglutide. We tested hypotheses in silenced cells (SH-SY5Y) treated with 2-deoxy-d-glucose (2DG) methylglyoxal (MG), stressors causing altered trafficking, glucotoxicity protein glycation. Rescue by liraglutide was investigated. silencing caused increased levels reactive oxygen species, upregulated energy...
This study aims to recover the main by-product of Citrus fruits processing, raw pomace, known also as pastazzo, produce plant complexes be used in treatment inflammatory bowel disease (IBD). Food-grade extracts from orange (OE) and lemon (LE) pomace were obtained by ultrasound-assisted maceration. After a preliminary phytochemical biological screening vitro assays, primary secondary metabolites characterized proton nuclear magnetic resonance (1H-NMR) liquid chromatography coupled diode array...
Background Hepatoblastoma (HB) is the most common pediatric hepatic malignancy. Despite progress in HB treatment, investigating pathomechanisms to optimize stratification and therapies remains a focal point improve outcome for high-risk patients. Methods Here, we pointed explore impact of these mechanisms HB. An observational study was performed on liver samples from cohort 17 patients with diagnosis two normal samples. The vitro experiments were executed Huh6 human cell line treated FAK...
Abstract Background Hepatocellular carcinoma (HCC) is one of the most common and lethal malignant tumours worldwide. Sorafenib (SOR) effective single-drug systemic therapy against advanced HCC, but identification novel combination regimens for a continued improvement in overall survival big challenge. Recent studies highlighted crucial role focal adhesion kinase (FAK) HCC growth. The aim this study was to investigate antitumor effects three different FAK inhibitors, alone or with SOR, using...