A5074283341- Algal biology and biofuel production
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Astro and Planetary Science
- Protein Interaction Studies and Fluorescence Analysis
- Liver Disease Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Planetary Science and Exploration
- Nanoparticle-Based Drug Delivery
- Porphyrin and Phthalocyanine Chemistry
- Stellar, planetary, and galactic studies
- Cancer Genomics and Diagnostics
- Cardiovascular Function and Risk Factors
- Histone Deacetylase Inhibitors Research
- Cancer-related molecular mechanisms research
- Aquatic Ecosystems and Phytoplankton Dynamics
- RNA modifications and cancer
- Chromatin Remodeling and Cancer
- Microbial Metabolic Engineering and Bioproduction
- Neonatal Health and Biochemistry
- Neuroblastoma Research and Treatments
- Single-cell and spatial transcriptomics
- PARP inhibition in cancer therapy
- Diet, Metabolism, and Disease
- Lipid metabolism and disorders
Czech Academy of Sciences, Global Change Research Institute
2014-2025
University of Pavol Jozef Šafárik
2010-2014
We characterized the photoautotrophic growth of glucose‐tolerant Synechocystis sp. PCC 6803 in a flat‐panel photobioreactor running on semicontinuous regime under various lights, temperatures, and influx carbon dioxide concentrations. The maximum reached rate was 0.135 h −1 , which corresponds to doubling time 5.13 h—a speed never reported for before. Saturating red light intensity strain 220–360 μmol(photons) m −2 s we did not observe any photoinhibition up 660 . able grow only; however,...
Abstract Background Although metabolic associate fatty liver disease (MAFLD) is associated with obesity, it can also occur in lean patients. MAFLD more aggressive patients compared to obese patients, a higher risk of mortality. Specific biomarkers diagnose differentially or overweight are missing. Histones and nucleosomes released the bloodstream upon cell death. Here, we propose new, fast, imaging epigenetics based approach investigate severity steatosis Results A total 53 non-obese...
Nonalcoholic fatty liver disease (NAFLD) has become the most common chronic in children and adolescents, increasing risk of its progression toward nonalcoholic steatohepatitis (NASH), cirrhosis, cancer. There is an urgent need for noninvasive early diagnostic prognostic tools such as epigenetic marks (epimarks), which would replace biopsy future. We used plasma samples from 67 with biopsy-proven NAFLD, controls we 20 negative steatosis by ultrasound. All patients were genotyped patatin-like...
Abstract We provide the circumstances and details of fireball observation, search expeditions, recovery, strewn field, physical characteristics Košice meteorite that fell in Slovakia on February 28, 2010. The was only 15th case an observed bolide with a recovered mass subsequent orbit determination. Despite multiple eyewitness reports bolide, three videos from security cameras Hungary were used for field determination computation. Multiple expeditions professionals individual searchers found...
As treatment options for patients with incurable metastatic castration-resistant prostate cancer (mCRPC) are considerably limited, novel effective therapeutic needed. Checkpoint kinase 1 (CHK1) is a highly conserved protein implicated in the DNA damage response (DDR) pathway that prevents accumulation of and controls regular genome duplication. CHK1 has been associated (PCa) induction, progression, lethality; hence, inhibitors SCH900776 (also known as MK-8776) more analog MU380 may have...
Steady-state and time-resolved fluorescence spectroscopy have been used for the study of incorporation kinetics hypericin (Hyp) into low-density lipoproteins (LDL). Biphasic Hyp association with LDL was observed when solutions were mixed at various concentration ratios. The rapid phase is completed within seconds, while slow lasts several minutes. relative contributions individual phases show that a higher amount molecules (65%) are incorporated in second phase. particles preloaded...
Hypericin (Hyp) is a promising photosensitizer for photodiagnosis and photodynamic therapy of cancer.However, Hyp has large conjugated system in aqueous solutions forms insoluble aggregates which do not possess biological activity.This makes intravenous injection problematic restricts its medical applications.To overcome this problem, incorporated into drug delivery systems can increase solubility bioavailability.One the possibilities utilization polymeric micelles.The most used hydrophilic...
Polyunsaturated fatty acids (PUFAs) are essential nutrients that humans obtain from their diet, primarily through fish oil consumption. However, production is no longer sustainable. An alternative approach to produce PUFAs marine microalgae. Despite the potential of algae strains accumulate high concentrations PUFAs, including (EFAs), many aspects PUFA by microalgae remain unexplored and current outputs frequently suboptimal.
Introduction: Pediatric brain tumours (PBT) are one of the most common malignancies during childhood, with variable severity according to location and histological type. Certain types gliomas, such a glioblastoma diffuse intrinsic pontine glioma (DIPG), have much higher mortality than ependymoma medulloblastoma. Early detection PBT is essential for diagnosis therapeutic interventions. Liquid biopsies been demonstrated using cerebrospinal fluid (CSF), mostly restricted cell free DNA, which...
Low-density lipoproteins (LDL), a natural <i>in vivo</i> carrier of cholesterol in the vascular system, play key role delivery hydrophobic photosensitizers (pts) to tumor cells photodynamic therapy (PDT) cancer. To make this system even more efficient, we have constructed nano-delivery by coating LDL surface polyethylene glycol (PEG) and dextran. Fluorescence spectroscopy confocal fluorescence imaging were used characterize redistribution hypericin (Hyp), potent pts, loaded LDL/PEG...