A5011575759- Peptidase Inhibition and Analysis
- Viral Infections and Vectors
- Vector-borne infectious diseases
- Vector-Borne Animal Diseases
- Ferrocene Chemistry and Applications
- Tracheal and airway disorders
- Asymmetric Hydrogenation and Catalysis
- Phosphodiesterase function and regulation
- Metal complexes synthesis and properties
- Chemical Synthesis and Analysis
- Voice and Speech Disorders
- Head and Neck Cancer Studies
- Cancer-related Molecular Pathways
- Hematological disorders and diagnostics
- Pneumocystis jirovecii pneumonia detection and treatment
- Enzyme function and inhibition
- Neuropeptides and Animal Physiology
- Biochemical and Structural Characterization
- Yersinia bacterium, plague, ectoparasites research
- Bacterial biofilms and quorum sensing
- Dysphagia Assessment and Management
- Chemical Reactions and Mechanisms
- Protease and Inhibitor Mechanisms
- Trace Elements in Health
- Inflammasome and immune disorders
University of Pisa
2022-2025
National Research Council
2025
Istituto di Fisiologia Clinica
2025
University of Palermo
1984-2003
Azienda Ospedaliero Universitaria Ospedali Riuniti
1984
Background/Objectives: The ability of bacteria to form biofilms makes them more tolerant traditional antibiotics. Given the lack new antibiotic development, drug repurposing offers a strategy for discovering treatments. Auranofin (AF), gold-based compound indicated treatment rheumatoid arthritis, shows promising antibacterial activity. This study investigates antimicrobial and antibiofilm activity AF its two derivatives in which thiosugar ligand is replaced by acetylcysteine (AF-AcCys) or...
Carbonic anhydrases (CAs) are widespread metalloenzymes which catalyse the reversible hydration of carbon dioxide (CO2) to bicarbonate (HCO3−) and a proton, relevant in many physiological processes. In last few years, involvement CA activation different metabolic pathways human brain addressed research discovery novel activators. Here, new series isoxazoline-based amino alcohols as activators was investigated. The synthesis activating effects towards four isoforms expressed brain, that hCAs...
The proteolytic activity of the enzyme ADAMTS7 was recently shown to enhance progression atherosclerosis, in line with human genetic findings suggesting that has a role pathophysiology coronary heart disease. Targeting active site small molecule inhibitor, therefore, therapeutic potential. Here, we report design and synthesis novel hydroxamate-based arylsulfonamide is potent selective inhibitor.
Matrix metalloproteinase 13 plays a central role in osteoarthritis (OA), as its overexpression induces an excessive breakdown of collagen that results imbalance between synthesis and degradation the joint, leading to progressive articular cartilage degradation. Therefore, MMP-13 has been proposed key therapeutic target for OA. Here we have developed virtual screening workflow aimed at identifying selective non-zinc-binding inhibitors by targeting deep S1′ pocket MMP-13. Three ligands were...
A human case of rickettsial infection occurred in Sicily following tick bite. The patient did not have fever, the typical nodular rash, or other symptoms illness than development a tache noire containing spotted fever group rickettsiae, which were demonstrated by immunofluorescence. high titer antibodies IgG class suggests that may had previous exposure to Rickettsia conorii related rickettsia. An anamnestic response be hypothesized conferred partial immunity, with resulting containment...
Multinuclear complexes are metal compounds featured by adjacent bound centers that can lead to unconventional reactivity. Some M
Intracellular pathogens, such as Chlamydia trachomatis, have been recently shown to induce degradation of p53 during infection, thus impairing the protective response host cells. Therefore, reactivation by disruption p53-MDM2 complex could reduce infection and restore pro-apoptotic effect p53. Here, we report identification a novel MDM2 inhibitor with potential antitumoural antibacterial activity able reactivate A virtual screening was performed on an in-house chemical library, previously...
<h3>To the Editor.—</h3> Abdominal involvement is unusual not only in Rocky Mountain Spotted Fever (RMSF), as pointed out by Davis and Bradford inThe Journal(1982;247:2811), but also another milder rickettsiosis, which, surprisingly, has an increased incidence our country. Boutonneuse fever (BF), caused by<i>Rickettsia conorii</i>, related to RMSF for several reasons, including a history of tick contact and/or eschar, summer incidence, fever, or characteristic rash. <h3>Report Cases.—Case...