The paper presents the design and validation of body-conformal active ultrasound patches with integrated imaging modulation modalities for image-guided neural therapy. A mechanically-flexible linear 64-element array piezoelectric transducers a resonance frequency 5 MHz was designed nerve localization. second 8-element using larger elements on wearable probe low intensity focused neuromodulation at 1.3 MHz. Full-wave simulations were used to model flexible arrays estimate their generated...

This letter describes the design, fabrication, and testing of a wireless bladder-pressure-sensing system for chronic, point-of-care applications, such as urodynamics or closed-loop neuromodulation. The consists miniature implantable device an external RF receiver battery charger. implant is small enough to be cystoscopically implanted within bladder wall, where it securely held shielded from urine stream. custom application-specific integrated circuit (ASIC), pressure transducer,...

The wireless implantable/intracavity micromanometer (WIMM) system was designed to fulfill the unmet need for a chronic bladder pressure sensing device in urological fields such as urodynamics diagnosis and neuromodulation control. Neuromodulation particular would benefit from sensor which could provide real-time feedback an implanted stimulator, resulting greater capacity while using less power. WIMM uses custom integrated circuitry, MEMS transducer, antenna transmit telemetry at rate of 10...

Regular monitoring of blood flow and pressure in vascular reconstructions or grafts would provide early warning graft failure improve salvage procedures. Based on biocompatible materials, we have developed a new type thin, flexible pulsation sensor (FPS) which is wrapped around to monitor flow. The FPS uses carbon black (CB) nanoparticles dispersed polydimethylsiloxane (PDMS) as piezoresistive layer, was encapsulated within structural PDMS layers connected stainless steel interconnect leads....

Aims Managing bladder pressure in patients with neurogenic bladders is needed to improve rehabilitation options, avoid upper tract damage, incontinence, and their associated co-morbidities mortality. Current methods of determining contractions are not amenable chronic or ambulatory settings. In this study we evaluated detection using a novel piezoelectric catheter-free sensor placed suburothelial location animals. Methods Wired prototypes the monitor were implanted into 2 nonsurvival (feline...

Diagnosis of lower urinary tract dysfunction with urodynamics has historically relied on data acquired from multiple sensors using nonphysiologically fast cystometric filling. In addition, state-of-the-art neuromodulation approaches to restore bladder function could benefit a sensor for closed-loop control, but practical and automated analysis are not available. We have developed an algorithm real-time event detection based single in situ sensor, making it attractive both extended ambulatory...

No AccessJournal of UrologyNew Technology and Techniques1 Jul 2023First in Human Subjects Testing the UroMonitor: A Catheter-free Wireless Ambulatory Bladder Pressure MonitorThis article is commented on by following:Editorial Comment Brendan T. Frainey, Steve J. A. Majerus, Samir Derisavifard, Kevin C. Lewis, Anna R. Williams, Brian M. Balog, Robert S. Butler, Howard B. Goldman, Margot Damaser FraineyBrendan Frainey Glickman Urological Kidney Institute, Cleveland Clinic, Cleveland, Ohio ,...

There has been recent interest in placing pressure-sensing elements beneath the bladder mucosa to facilitate chronic pressure monitoring. Wired submucosal sensors with wires passed through detrusor have demonstrated vivo, limited retention, potentially due cable tethering detrusor. Published studies of implants shown that high correlation coefficients between and lumen pressures can be obtained caprine, feline, canine models. We developed a wireless monitor surgical technique for...

Continuous monitoring of bladder activity during normal daily activities would improve clinical diagnostics and understanding the mechanisms underlying function, or help validate how differing neuromodulation strategies affect bladder. This work describes a urological monitor conscious (UroMOCA). The UroMOCA included pressure sensor, urine impedance-sensing electrodes, wireless battery recharge data transmission circuitry. Components were assembled on circuit board encapsulated with an...

This paper describes a wireless system to monitor urinary bladder pressure comprising an implantable device with external receiver and battery charger. The is intended be implanted within the wall, sealed behind urothelial lining. location protected from urine stream, thus avoiding mineral encrustation stone formation, suitable measure intravesical in chronic applications. implant dimensionally designed gain access using conventional urological tools, e.g. cystoscope. active circuit features...

Conditional neuromodulation in which neurostimulation is applied or modified based on feedback a viable approach for enhanced bladder functional stimulation. Current methods measuring pressure rely exclusively external catheters placed the lumen. This has limited utility ambulatory use as required chronic therapy. We have developed wireless monitor to provide real-time, catheter-free measurements of support conditional neuromodulation. The device sized submucosal cystoscopic implantation...

We report on the development of a non-hermetic micropackage technology that employs multiple layers polydimethylsiloxane (PDMS), epoxy, and parylene-C thin films for conformal coating chronic biomedical implantable systems with laboratory testing results in saline bath at 85°C, achieving very long micropackaging lifetime (up to ~2–5 years). By combining experiments material characterization qualitative analysis observations, we explain measured lifetimes micropackages (projected equivalent...

Conditional neuromodulation is a form of closed-loop bladder control where neurostimulation applied in reaction to pressure changes. Current methods based on external catheters have limited utility for chronic ambulatory therapy. We developed wireless monitor provide real-time, catheter-free detection contractions. The device sized implantation the muscle. consists an ultra-low-power application specific integrated circuit (ASIC), micro-electro-mechanical (MEMS) sensor, RF antennas, and...

This paper reports long-term evaluation of a micropackage technology for an implantable MEMS pressure sensor. The all-polymer survived > 160 days when subjected to accelerated lifetime testing at 85°C in 1% wt. saline solution. package exhibited minimum impact on sensitivity and linearity, which deviated by less than 5% 0.3%, respectively. A 6-month vivo 16 MEMS-based sensors showed that the exhibits good biocompatibility provides excellent protection. To best our knowledge, these results...

Continuous sacral neuromodulation (SNM) is used to treat overactive bladder, reducing urine leakage and increasing capacity. Conditional SNM applies stimulation in response changing bladder conditions, an opportunity study effects various disease states. A key advantage of this approach saving power consumed by pulses. This demonstrated feasibility automatically applying using a wireless pressure sensor, real-time control algorithm, the Medtronic Summit™ RC+S neurostimulation research...

This work demonstrates a batteryless, implan- table blood-flow sensor with radio frequency identification (RFID) readout. flexible system was developed specifically for surgical implantation around blood vessel, without contacting to reduce platelet deposition, clotting, and other complications blood-contacting sensors. A circuit architecture adopted enable cuff-like form factor an artery, vein, or graft piercing cutting the vessel. required development of RFID data/power antenna using...

Researchers at Case Western Reserve University (CWRU) and BluBerry, LLC have worked to extend the useful operating temperature range of low-cost, bulk CMOS instrumentation actuation ICs greater than 200°C. In this manuscript, we review motivation, challenges, circuit techniques employed operate circuits extended temperatures. Initial research CWRU yielded monolithic clock oscillators, amplifiers, sigma-delta analog-to-digital converters capable stable, high-performance operation beyond To...

Point-of-care screening for hemodialysis vascular access dysfunction requires tools that are objective and efficient. Listening bruits during physical exam is a subjective examination which can detect stenosis (vascular narrowing) when properly performed. Phonoangiograms (PAGs)-mathematical analysis of bruits-increases the objectivity sensitivity permits quantification location degree (DOS). This work describes flexible body-conformal multi-channel sensor associated signal processing methods...

Lower urinary tract dysfunction (LUTD) is a debilitating condition that affects millions of individuals worldwide, greatly diminishing their quality life. The use wireless, catheter-free implantable devices for long-term ambulatory bladder monitoring, combined with single-sensor system capable detecting various events, has the potential to significantly enhance diagnosis and treatment LUTD. However, these systems produce large amounts data may contain physiological noise in pressure signals...

Lower urinary tract dysfunctions, such as incontinence and overactive bladder, are conditions that greatly affect the quality of life for millions individuals worldwide. For those with more complex pathophysiologies, diagnosis these often requires a urodynamics study, providing physicians snapshot view bladder mechanics. Recent advancements in implantable pressure monitors advanced data analysis techniques have made through chronic monitoring promising prospect. However, implants targeted at...

Real-time monitoring of arteriovenous graft blood flow would provide early warning failure to permit interventions such as angioplasty or replacement avoid catastrophic failure. We have developed a new type flexible pulsation sensor (FPS) consisting 3D printed elastic cuff wrapped around and thus not in contact with blood. The FPS uses multi-walled carbon nanotubes (MWCNTs) dispersed polydimethylsiloxane (PDMS) piezoresistive layer, which is embedded within structural thixotropic PDMS. These...