A5056346051- Zebrafish Biomedical Research Applications
- Sleep and Wakefulness Research
- Thyroid Disorders and Treatments
- Circadian rhythm and melatonin
- Neural dynamics and brain function
- Growth Hormone and Insulin-like Growth Factors
- Neuroscience and Neuropharmacology Research
- Animal Behavior and Reproduction
- Birth, Development, and Health
- Mitochondrial Function and Pathology
- RNA regulation and disease
- Retinoids in leukemia and cellular processes
- RNA Interference and Gene Delivery
- Advanced Fluorescence Microscopy Techniques
- Pregnancy and preeclampsia studies
- Genetics and Neurodevelopmental Disorders
- Congenital heart defects research
- Fibroblast Growth Factor Research
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Neurobiology and Insect Physiology Research
- Photoreceptor and optogenetics research
- interferon and immune responses
- Neonatal Health and Biochemistry
- Genetic Syndromes and Imprinting
University of California, San Diego
2023-2024
Bar-Ilan University
2012-2023
Abstract Sleep is essential to all animals with a nervous system. Nevertheless, the core cellular function of sleep unknown, and there no conserved molecular marker define across phylogeny. Time-lapse imaging chromosomal markers in single cells live zebrafish revealed that increases chromosome dynamics individual neurons but not two other cell types. Manipulation sleep, dynamics, neuronal activity, DNA double-strand breaks (DSBs) showed are low number DSBs accumulates during wakefulness. In...
The collective behavior of animal groups emerges from the interactions among individuals. These social produce coordinated movements bird flocks and fish schools, but little is known about their developmental emergence neurobiological foundations. By characterizing visually based schooling micro glassfish Danionella cerebrum, we found that development progresses sequentially, with animals first acquiring ability to aggregate, followed by postural alignment partners. This maturation was...
The mechanisms and treatment of psychomotor retardation, which includes motor cognitive impairment, are indefinite. Allan-Herndon-Dudley syndrome (AHDS) is an X-linked retardation characterized by delayed development, severe intellectual disability, muscle hypotonia, spastic paraplegia, in combination with disturbed thyroid hormone (TH) parameters. AHDS has been associated mutations the monocarboxylate transporter 8 (mct8/slc16a2) gene, a TH transporter. In order to determine...
Allan-Herndon-Dudley syndrome (AHDS) is a severe psychomotor retardation characterized by neurological impairment and abnormal thyroid hormone (TH) levels. Mutations in the TH transporter, monocarboxylate transporter 8 (MCT8), are associated with AHDS. MCT8 knock-out mice exhibit impaired levels; however, they lack defects. Here, zebrafish mct8 gene promoter were isolated, promoter-driven transgenic lines used to show that, similar humans, primarily expressed nervous vascular systems....
ABSTRACT Hypomyelination is a key symptom of Allan-Herndon-Dudley syndrome (AHDS), psychomotor retardation associated with mutations in the thyroid-hormone (TH) transporter MCT8 (monocarboxylate 8). AHDS characterized by severe intellectual deficiency, neuromuscular impairment and brain hypothyroidism. In order to understand mechanism for TH-dependent hypomyelination, we developed an mct8 mutant (mct8−/−) zebrafish model. The quantification genetic markers oligodendrocyte progenitor cells...
Glial cells support the function of neurons. Recent evidence shows that astrocytes are also involved in brain computations. To explore whether and how their excitable nature affects computations motor behaviors, we used two-photon Ca
Background: The thyroid hormones (THs) triiodothyronine (T3) and thyroxine (T4) are crucial regulators of brain development function. Cell-specific transporter proteins facilitate TH uptake efflux across the cell membrane, insufficient transport causes hypothyroidism mental retardation. Mutations in transporters monocarboxylate 8 (MCT8, SLC16A2) organic anion-transporting polypeptide 1C1 (OATP1C1, SLCO1C1) associated with psychomotor retardation Allan-Herndon-Dudley syndrome juvenile...
Abstract Many animals move in groups, where collective behavior emerges from the interactions amongst individuals. These social produce coordinated movements of bird flocks and fish schools, but little is known about their developmental emergence neurobiological foundations. By characterizing visually-based schooling micro glassfish Danionella cerebrum , here we found that development progresses sequentially, with first acquiring ability to aggregate, followed by postural alignment partners....
Thyroid hormones (THs; T3 and T4) enter cells using specific transporters regulate development metabolism. Mutation in the TH transporter monocarboxylate 8 (MCT8, SLC16A2) is associated with brain hypothyroidism neurological impairment. We established mct8 mutant (mct8-/-) zebrafish as a model for MCT8 deficiency, which causes endocrinological, neurological, behavioral alterations. Here, we profiled transcriptome of mct8-/- larvae. Among hundreds differentially expressed genes, expression...
Hypothyroidism is a common pathological condition characterized by insufficient activity of the thyroid hormones (THs), thyroxine (T4), and 3,5,3'-triiodothyronine (T3), in whole body or specific tissues. associated with inadequate development intestine as well gastrointestinal diseases. We used zebrafish model hypothyroidism to identify characterize TH-modulated genes cellular pathways controlling development. In hypothyroid juveniles adults, number mucus-secreting goblet cells was reduced,...