A5071197927- Sleep and Wakefulness Research
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Retinal Development and Disorders
- Memory and Neural Mechanisms
- Sleep and related disorders
- EEG and Brain-Computer Interfaces
- Circadian rhythm and melatonin
- Photoacoustic and Ultrasonic Imaging
- RNA Interference and Gene Delivery
- Ultrasound and Cavitation Phenomena
- Ultrasound and Hyperthermia Applications
- Neuroscience and Neuropharmacology Research
Tel Aviv University
2019-2024
Stanford University
2024
A defining feature of sleep is reduced responsiveness to external stimuli, but the mechanisms mediating sensory-evoked arousal remain unclear. We hypothesized that locus coeruleus (LC) norepinephrine (NE) activity during mediates unresponsiveness, and its action promotes awakenings. tested this using electrophysiological, behavioral, pharmacological, optogenetic techniques alongside auditory stimulation in freely behaving rats. found systemic reduction NE signaling lowered probability...
Abstract Information is transmitted between brain regions through the release of neurotransmitters from long-range projecting axons. Understanding how activity such connections contributes to behavior requires efficient methods for reversibly manipulating their function. Chemogenetic and optogenetic tools, acting endogenous G-protein-coupled receptor pathways, can be used modulate synaptic transmission, but existing tools are limited in sensitivity, spatiotemporal precision or spectral...
Abstract The claustrum has been linked to attention and sleep. We hypothesized that this reflects a shared function, determining responsiveness stimuli, which spans the axis of engagement. To test hypothesis, we recorded population dynamics from male mice during both sleep an attentional task (‘ENGAGE’). Heightened activity in neurons projecting anterior cingulate cortex (ACCp) corresponded reduced sensory Similarly, ENGAGE task, heightened ACCp correlated with disengagement behavioral...
The locus coeruleus norepinephrine (LC-NE) system regulates arousal and awakening; however, it remains unclear whether the LC does this in a global or circuit specific manner. We hypothesized that sensory-evoked awakenings are predominantly regulated by LC-NE efferent pathways. Anatomical, physiological, functional modularities of pathways involving mouse basal forebrain (BF) pontine reticular nucleus (PRN) were tested. found partial anatomical segregation between LC->PRN LC->BF...
Abstract Engagement is a major determinant of performance. Hyper-engagement risks impulsivity and fatiguing over time, while hypo-engagement could lead to missed opportunities. Even in sleep, when engagement levels are minimal, sensory responsiveness varies. Thus, maintaining an optimal level with the environment fundamental cognitive ability. The claustrum, particular its reciprocal connectivity executive regions frontal cortex, has been associated salience, attention sleep. These...
Abstract A defining feature of sleep is reduced responsiveness to external stimuli, but the mechanisms gating sensory-evoked arousal remain unclear. We hypothesized that locus-coeruleus norepinephrine (LC-NE) activity during mediates unresponsiveness, and its action promotes awakenings. tested this using electrophysiological, behavioral, pharmacological, optogenetic techniques alongside auditory stimulation in freely behaving rats. found systemic reduction NE signaling lowered probability...
Information is transmitted between brain regions through the release of neurotransmitters from long-range projecting axons. Understanding how activity such connections contributes to behavior requires efficient methods for reversibly manipulating their function. Chemogenetic and optogenetic tools, acting endogenous G-protein coupled receptor (GPCRs) pathways, can be used modulate synaptic transmission, but existing tools are limited in sensitivity, spatiotemporal precision, or spectral...