A5078700214- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Photoreceptor and optogenetics research
- Sleep and Wakefulness Research
- Ectopic Pregnancy Diagnosis and Management
- Prenatal Screening and Diagnostics
- Olfactory and Sensory Function Studies
- Cellular transport and secretion
- Retinal Development and Disorders
- Pregnancy and preeclampsia studies
- Voice and Speech Disorders
- Parkinson's Disease Mechanisms and Treatments
- Blood groups and transfusion
- Nicotinic Acetylcholine Receptors Study
- Reproductive System and Pregnancy
- Parvovirus B19 Infection Studies
- Child Nutrition and Water Access
- Neurobiology and Insect Physiology Research
- Gestational Diabetes Research and Management
- EEG and Brain-Computer Interfaces
- Genomics, phytochemicals, and oxidative stress
- Fetal and Pediatric Neurological Disorders
- Nanocomposite Films for Food Packaging
- Insect and Pesticide Research
Tel Aviv University
2009-2024
Sheba Medical Center
2020-2023
United States Nuclear Regulatory Commission
2021
Rabin Medical Center
2020
Afeka College of Engineering
2015
Arthur M. Sackler Gallery
2011
A defining feature of sleep is reduced responsiveness to external stimuli, but the mechanisms mediating sensory-evoked arousal remain unclear. We hypothesized that locus coeruleus (LC) norepinephrine (NE) activity during mediates unresponsiveness, and its action promotes awakenings. tested this using electrophysiological, behavioral, pharmacological, optogenetic techniques alongside auditory stimulation in freely behaving rats. found systemic reduction NE signaling lowered probability...
To determine the immunogenicity and reactogenicity of Pfizer/BioNTech BNT162b2 mRNA coronavirus disease 2019 (COVID-19) vaccine among pregnant women compared with non-pregnant women, to evaluate obstetric outcome following vaccination.
Abstract Information is transmitted between brain regions through the release of neurotransmitters from long-range projecting axons. Understanding how activity such connections contributes to behavior requires efficient methods for reversibly manipulating their function. Chemogenetic and optogenetic tools, acting endogenous G-protein-coupled receptor pathways, can be used modulate synaptic transmission, but existing tools are limited in sensitivity, spatiotemporal precision or spectral...
Drugs currently used for treating Parkinson's disease patients provide symptomatic relief without altering the neurodegenerative process. Our aim was to examine possibility of using DJ-1 (PARK7), as a novel therapeutic target disease. We designed short peptide, named ND-13. This peptide consists 13 amino acids segment DJ-1-protein attached 7 derived from TAT, cell penetrating protein. examined effects ND-13 in vitro and vivo experimental models demonstrated that protects cultured cells...
The locus coeruleus norepinephrine (LC-NE) system regulates arousal and awakening; however, it remains unclear whether the LC does this in a global or circuit specific manner. We hypothesized that sensory-evoked awakenings are predominantly regulated by LC-NE efferent pathways. Anatomical, physiological, functional modularities of pathways involving mouse basal forebrain (BF) pontine reticular nucleus (PRN) were tested. found partial anatomical segregation between LC->PRN LC->BF...
Neurotoxin receptor site-3 at voltage-gated Na(+) channels is recognized by various peptide toxin inhibitors of channel inactivation. Despite extensive studies the effects these toxins, their mode interaction with remained to be described molecular level. To identify constituents that interact we exploited opposing preferences LqhαIT and Lqh2 scorpion α-toxins for insect mammalian brain channels. Construction DIV/S1-S2, DIV/S3-S4, DI/S5-SS1, DI/SS2-S6 external loops rat rNa(v)1.2a (highly...
Whereas neuronal M-type K + channels composed of KCNQ2 and KCNQ3 subunits regulate firing properties neurons, presynaptic were demonstrated to neurotransmitter release by directly influencing function. Two interaction partners M-channels, syntaxin 1A calmodulin, are known act presynaptically, serving as a major protein component the membrane fusion machinery calmodulin regulator several processes related release. Notably, both specifically modulate but not subunits, suggesting selective...
A fundamental feature of sleep is reduced behavioral responsiveness to external events, but the extent processing along sensory pathways remains poorly understood. While responses are comparable across wakefulness and in auditory cortex (AC), neuronal activity downstream regions unknown. Here we recorded spiking 435 clusters evoked by acoustic stimuli perirhinal (PRC) AC freely behaving male rats sleep. Neuronal showed modest (∼10%) differences response gain vigilance states, replicating...
KCNQ2/KCNQ3 channels are the molecular correlates of neuronal M-channels, which play a major role in control excitability. Notably, they differ from homomeric KCNQ2 their distribution pattern within neurons, with unique expression axons and nerve terminals. Here, combined reciprocal coimmunoprecipitation two-electrode voltage clamp analyses Xenopus oocytes revealed strong association syntaxin 1A, component exocytotic SNARE complex, resulting ∼2-fold reduction macroscopic conductance slower...
Av3 is a peptide neurotoxin from the sea anemone Anemonia viridis that shows specificity for arthropod voltage-gated sodium channels (Navs). Interestingly, competes with scorpion α-toxin on binding to insect Navs and similarly inhibits inactivation process, thus has been classified as ‘receptor site-3 toxin’, although two peptides are structurally unrelated. This raises questions commonalities differences in way both toxins interact Navs. Recently, was partly resolved α-toxins highlighting...
Abstract A defining feature of sleep is reduced responsiveness to external stimuli, but the mechanisms gating sensory-evoked arousal remain unclear. We hypothesized that locus-coeruleus norepinephrine (LC-NE) activity during mediates unresponsiveness, and its action promotes awakenings. tested this using electrophysiological, behavioral, pharmacological, optogenetic techniques alongside auditory stimulation in freely behaving rats. found systemic reduction NE signaling lowered probability...
Information is transmitted between brain regions through the release of neurotransmitters from long-range projecting axons. Understanding how activity such connections contributes to behavior requires efficient methods for reversibly manipulating their function. Chemogenetic and optogenetic tools, acting endogenous G-protein coupled receptor (GPCRs) pathways, can be used modulate synaptic transmission, but existing tools are limited in sensitivity, spatiotemporal precision, or spectral...
Despite extensive knowledge of its molecular and cellular effects, how anesthesia affects sensory processing remains poorly understood. In particular, it unclear whether modestly or robustly degrades activity in primary regions, such changes are linked to drug concentration versus behavioral unresponsiveness, which typically confounded. Here, we used slow gradual intravenous propofol induction together with auditory stimulation intermittent assessment responsiveness while recording epidural...
Objective: The present study compared the mineral contents of enamel and dentin primary teeth from children exposed to desalinated water with those drinking ground water. Study design: comprised two groups teeth, seven living in areas supplied exclusively that have been solely in-utero until were either extracted or naturally shed. Mineral content three tooth regions was determined by scanning electron microscopy an energy dispersive X-ray spectrometer (EDS). main ion each region calculated....
Abstract A fundamental feature of sleep is reduced behavioral responsiveness to external events, but the extent processing along sensory pathways remains poorly understood. While responses are comparable across wakefulness and in auditory cortex (AC), neuronal activity downstream regions unknown. Here we recorded spiking 435 clusters evoked by acoustic stimuli perirhinal (PRC) AC freely behaving male rats sleep. Neuronal showed modest (around 10%) differences response gain vigilance states,...
To compare outcome of selective termination (ST) performed in the late 2nd and 3rd trimesters to identify factors associated with preterm birth (PTB) following procedure. A retrospective cohort study ST (≥20 weeks gestation) dichorionic twins at a single tertiary centre. Outcomes were compared between trimester (200/7-276/7 weeks) (≥ 280/7 STs. An additional comparison was conducted term births (< 37 total 81 pregnancies included. The median gestational age time procedure 31 (range 20.2-35.2...
Vaginal delivery of a large for gestational age fetus holds an increased risk maternal and neonatal complications. We aimed to evaluate the impact recent sonographic fetal weight estimation on adverse outcomes. A retrospective cohort study all singleton, LGA (≥ 90th %) neonates was conducted. The divided into: Group A) that had (≤ 14 days before delivery) estimation; B) who lacked such estimation. Outcomes were compared. Overall, 1,295 included - 733 (56.6%) in group 562 (43.4%) B....
Abstract Despite extensive knowledge of its molecular and cellular effects, how anesthesia affects sensory processing remains poorly understood. In particular, it unclear whether modestly or robustly degrades activity in primary regions, such changes are linked to drug concentration vs. behavioral unresponsiveness, since these typically confounded. Here, we employed slow gradual intravenous propofol induction together with auditory stimulation intermittent assessment responsiveness while...
To evaluate short- and long-term neurodevelopmental outcomes of children treated with intrauterine blood transfusion due to parvovirus B-19 infection versus red cell (RBC) alloimmunisation. All fetuses underwent brain imaging-sonograms every 4 weeks MRI at 28-32 gestation. a developmental intelligence evaluation according age testing. Short- were compared between the groups. A total 77 patients an IUT during study period. In 18, fetal anemia was attributed Parvo B19 in 59, RBC...