A5030180448- interferon and immune responses
- Viral Infections and Vectors
- RNA modifications and cancer
- Cytomegalovirus and herpesvirus research
- Immune cells in cancer
- Autoimmune and Inflammatory Disorders Research
- Mosquito-borne diseases and control
- Hematopoietic Stem Cell Transplantation
- Viral Infections and Outbreaks Research
- Platelet Disorders and Treatments
- Single-cell and spatial transcriptomics
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Acute Myeloid Leukemia Research
- Immune responses and vaccinations
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Inflammasome and immune disorders
TU Dresden
2020-2023
Abstract Hematopoietic stem cells (HSCs) produce highly diverse cell lineages. Here, we chart native lineage pathways emanating from HSCs and define their physiological regulation by computationally integrating experimental approaches for fate mapping, mitotic tracking, single-cell RNA sequencing. We find that lineages begin to split when leave the tip HSC population, marked high Sca-1 CD201 expression. Downstream, either retain expression ability generate lymphocytes, or irreversibly reduce...
Genome damage is a main driver of malignant transformation, but it also induces aberrant inflammation via the cGAS/STING DNA-sensing pathway. Activation can trigger cell death and senescence, thereby potentially eliminating genome-damaged cells preventing against transformation. Here, we report that defective ribonucleotide excision repair (RER) in hematopoietic system caused genome instability with concomitant activation axis compromised stem function, ultimately resulting leukemogenesis....
<p>Oligo nucleotide sequences</p>
<p>Supplementary Figures S1-8 and corresponding figure legends</p>
<p>List of antibodies used in the study</p>
<p>Supplementary Figures S1-8 and corresponding figure legends</p>
<p>Oligo nucleotide sequences</p>
<p>List of antibodies used in the study</p>
<div>Abstract<p>Genome damage is a main driver of malignant transformation, but it also induces aberrant inflammation via the cGAS/STING DNA sensing pathway. Activation can trigger cell death and senescence, thereby potentially eliminating genome-damaged cells preventing against transformation. Here, we report that defective ribonucleotide excision repair (RER) in hematopoietic system caused genome instability with concomitant activation axis compromised stem function, ultimately...
Abstract Hematopoietic stem cells (HSCs) produce a highly diverse array of cell lineages. To assay hematopoietic differentiation with minimal experimental perturbation, non-invasive methods for heritable labeling 1–3 or barcoding 4–7 HSCs in vivo have recently been developed and used to study lineage fate physiological conditions. However, the pathways leading from mature remain controversial 8 , suggested models ranging gradual restriction branching cascade progenitors already making...
<p>Supplementary Figures S1-8 and corresponding figure legends</p>
<div>Abstract<p>Genome damage is a main driver of malignant transformation, but it also induces aberrant inflammation via the cGAS/STING DNA-sensing pathway. Activation can trigger cell death and senescence, thereby potentially eliminating genome-damaged cells preventing against transformation. Here, we report that defective ribonucleotide excision repair (RER) in hematopoietic system caused genome instability with concomitant activation axis compromised stem function, ultimately...
<div>Abstract<p>Genome damage is a main driver of malignant transformation, but it also induces aberrant inflammation via the cGAS/STING DNA sensing pathway. Activation can trigger cell death and senescence, thereby potentially eliminating genome-damaged cells preventing against transformation. Here, we report that defective ribonucleotide excision repair (RER) in hematopoietic system caused genome instability with concomitant activation axis compromised stem function, ultimately...
<p>Oligo nucleotide sequences</p>
<p>Oligo nucleotide sequences</p>
<p>List of antibodies used in the study</p>
<p>List of antibodies used in the study</p>
<p>Supplementary Figures S1-8 and corresponding figure legends</p>
Abstract Cell-intrinsic response patterns control risks arising from genome-damage, preventing malignant transformation. The DNA sensor cyclic-GMP-AMP synthase (cGAS) has emerged as a new principle detecting genome damage, it can be triggered by aberrant self-DNA. Stimulator of interferon genes (STING)-activation downstream cGAS drive cells into senescence or cell death and induces antiproliferative type I (IFN) pro-apoptotic tumor necrosis factor responses. Herein, we investigated how...
Summary Hematopoietic stem cells (HSCs) are the ultimate source of blood and immune cells. Under homeostatic conditions, these considered a quiescent reserve population. However, it is not clear to what extent HSCs participate in emergency responses. Herein, we use fate mapping proliferation tracking mouse models, which cumulatively record HSC activity situ . We observed no direct contribution mature cell regeneration response common hematopoietic emergencies, including inflammation or loss....