A5061534358- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Blood disorders and treatments
- Cancer Risks and Factors
- Adolescent and Pediatric Healthcare
- Hematopoietic Stem Cell Transplantation
- Immunodeficiency and Autoimmune Disorders
- Autism Spectrum Disorder Research
- Child Nutrition and Feeding Issues
- Family and Disability Support Research
- Hematological disorders and diagnostics
- Nutrition and Health in Aging
- Neutropenia and Cancer Infections
- Innovations in Medical Education
- Cancer survivorship and care
- Nursing Roles and Practices
- Healthcare cost, quality, practices
- Infectious Encephalopathies and Encephalitis
- Clinical Reasoning and Diagnostic Skills
- Nasal Surgery and Airway Studies
- Family and Patient Care in Intensive Care Units
- Genomic variations and chromosomal abnormalities
- Mental Health and Patient Involvement
- Emergency and Acute Care Studies
British Columbia Children's Hospital
2019-2025
University of British Columbia
2019-2024
Montreal Children's Hospital
2021
Hospital for Sick Children
2015-2021
Public Health Agency of Canada
2021
Pediatric Oncology Group
2021
Université du Québec à Montréal
2021
Alberta Health Services
2021
University of Toronto
2014-2015
McMaster Children's Hospital
2013-2014
Children with acute lymphoblastic leukemia experience musculoskeletal morbidity during therapy. We examined the patterns of change in skeletal muscle mass (SMM) and relationship between SMM burden illness as reflected days hospitalization. Ninety-one children had dual energy x-ray absorptiometry (DXA scans) treatment, yielding sum lean tissue all 4 limbs; appendicular mass. was derived from The number inpatient recorded. DXA scans at 5 time points showed a profile characterized by drop mean...
Abstract Background Childhood obesity can result in adverse health outcomes. The objectives of this study were to describe the prevalence and determine association between at cancer diagnosis event‐free survival (EFS) overall (OS) children diagnosed with Canada. Methods authors conducted a retrospective cohort using Cancer Young People Canada database, including all newly aged 2–18 years across from 2001 2020. Obesity was defined as age‐adjusted sex‐adjusted body mass index greater than or...
Background Ideal management of chronic rhinosinusitis (CRS) requires ongoing monitoring disease and its control. Existing control instruments are limited in their correlation to patient reported outcomes, the need for endoscopy, or lack validation from a multidisciplinary group. The goal this study was develop patient‐based Sinus Control Test (SCT) determining CRS Methods A systematic literature review focus groups consisting 20 patients 11 medical experts various specialties were used...
To evaluate the relationship between lumbar spine (LS) bone mineral density (BMD) and patient-, disease-, therapy-related variables, to define risk-factors for fractures in children receiving therapy on Dana-Farber Cancer Institute acute lymphoblastic leukemia (ALL) protocols.Children (≤18 years) diagnosed with ALL during period 1995-2006, who are first clinical remission, were included (n = 124). Dual-energy X-ray absorptiometry provided LS-BMD at diagnosis 46) continuation therapy. was...
Illness and hospitalization lead to loss of school days education for some children. This issue has been addressed in published literature more than three decades (1). Regular attendance swift re-entry are considered be important mechanisms helping children cope with the management their illness (2,3). Helping stay connected regular academic social activities shown reduce difficulties during (4). Access a teacher being able continue within hospital provides sense normalcy stay. However,...
Over the last two decades, patient engagement in cancer research has evolved significantly, especially addressing unique challenges faced by adolescent and young adult (AYA) populations. This paper introduces a framework for meaningful with AYA partners, drawing insights from "FUTURE" Study, qualitative study that utilizes focus groups to explore impact of diagnosis treatment on sexual reproductive health patients Canada. The framework's development integrates prior works addresses specific...
Inherited bone marrow failure syndromes, such as Fanconi anemia (FA) and Shwachman-Diamond syndrome (SDS), feature progressive cytopenia a risk of acute myeloid leukemia (AML). Using deep phenotypic analysis early progenitors in FA/SDS samples, we revealed selective survival that phenotypically resembled granulocyte-monocyte (GMP). Whole-exome targeted sequencing GMP-like cells leukemia-free patients higher mutation load than healthy controls molecular changes are characteristic AML:...
Summary Progressive cytopenia is a serious complication among paediatric patients with inherited bone marrow failure syndromes (IBMFS). Androgens have been used to improve blood counts in different conditions. Little known about efficacy and toxicity new androgens (i.e., danazol) types of IBMFS. We identified 29 from the Canadian Inherited Marrow Failure Registry, who received oxymetholone or danazol. Sixteen (55%) had haematological response including unclassified IBMFS (45%). Danazol...
Access to hematopoietic stem cell transplantation (HSCT) in pediatric acute lymphoblastic leukemia (ALL) primarily depends on disease-related factors but may be influenced by social and economic determinants. We included all children aged < 15 years with newly diagnosed ALL Canada between 2001 2018 using the Cancer Young People national registry. examined potentially associated likelihood of receiving HSCT univariate multivariable logistic regression models. A total 3992 patients were...
<h3>Background:</h3> The COVID-19 pandemic has had a major impact on access to health care resources. Our objective was estimate the of incidence childhood cancer in Canada. We also aimed compare proportion patients who enrolled clinical trials at diagnosis, presented with metastatic disease or an early death during first 9 months compared previous years. <h3>Methods:</h3> conducted observational study that included children younger than 15 years new diagnosis between March 2016 and November...
10517 Background: Childhood obesity can result in a variety of adverse health outcomes. Objectives were to describe the prevalence and determine association between baseline with event-free survival (EFS) overall (OS) children diagnosed cancer Canada. Methods: We conducted retrospective cohort study using Cancer Young People Canada database, population-based surveillance program collecting data from all patients < 15 years old before 2015 19 after 2015. This included newly aged 2 18...
Classification of inherited bone marrow failure syndromes (IBMFSs) according to clinical and genetic diagnoses enables proper adjustment treatment. Unfortunately, 30% patients enrolled in the Canadian Inherited Marrow Failure Registry (CIMFR) with features suggesting hereditability could not be classified a specific syndromic diagnosis. We analyzed outcome hematopoietic stem cell transplantation (HSCT) unclassified IBMFSs (uIBMFSs) factors associated outcome. Twenty-two uIBMFSs 70 underwent...
e23080 Background: While treatment advances for adolescent and young adult (AYA, ages 15 - 39) cancers are improving survival, there is a lack of information support regarding impacts AYA cancer on sexual reproductive health (SRH) during after treatment. Our study explored SRH experiences patients using novel, serial focus groups. Methods: With online in-person approaches, we recruited folks who: 1) Were diagnosed with at age – 39; 2) Reside in Canada; 3) Are over 18. Participants were...
ABSTRACT Background and Aims Studies examing the impact of socioeconomic factors on outcomes in childhood acute lymphoblastic leukemia (ALL) have yielded inconsistent findings. We aimed to determine whether status (SES) or healthcare access are associated with presence potentially time‐sensitive high‐risk features at diagnosis, times diagnosis treatment, survival among children ALL Canada. Methods conducted a retrospective cohort study all aged less than 15 years diagnosed first primary...
Inherited bone marrow failure syndromes (IBMFSs) are genetically heterogeneous disorders with cytopenia. Many IBMFSs also feature physical malformations and an increased risk of cancer. Point mutations can be identified in about half patients. Copy number variation (CNVs) have been reported; however, the frequency spectrum CNVs unknown. Unfortunately, current genome-wide methods major limitations since they may miss small or low sensitivity due to read depths. Herein, we aimed determine...
Abstract Introduction Indications for hematopoietic stem cell transplantation (HSCT) in pediatric acute myeloid leukemia (AML) are primarily dependent on risk stratification at diagnosis and relapse status. We sought to determine whether access HSCT is influenced by regional socioeconomic factors. Methods Children with newly diagnosed AML aged < 15 years between 2001 2015 were identified using the Cancer Young People Canada national population–based registry. Factors potentially...
The Royal College of Physician and Surgeon Canada mandates that all pediatric trainees gain expertise in specific procedural skills prior to completing their training. current landscape medical education, however, may not provide residents with enough opportunity observe perform such skills. reason for this change is multifactorial; factors as reduction learners' working hours or a movement towards more non-invasive treatments. cumulative effect could be fail achieve the competency required...
Autism Spectrum Disorder (ASD) is associated with significant lifetime costs. The Early Start Denver Model (ESDM) has shown efficacy in children ASD as young 18 months. New service delivery models propose providing ASD-targeted treatment to who show signs of before a diagnosis. There are no studies examining the cost-effectiveness this model. We performed analysis comparing costs and dependency-free life years (DFLYs) generated by pre-diagnosis intensive ESDM (ESDM-I), parent-delivered...