A5002509133- Trypanosoma species research and implications
- Synthesis and Biological Evaluation
- Bioactive Compounds and Antitumor Agents
- Enzyme function and inhibition
- Phenothiazines and Benzothiazines Synthesis and Activities
- Research on Leishmaniasis Studies
- Parasitic Infections and Diagnostics
- Bacteriophages and microbial interactions
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Antibiotic Resistance in Bacteria
- Antimicrobial agents and applications
- Escherichia coli research studies
- RNA and protein synthesis mechanisms
- Marine Biology and Environmental Chemistry
- Analytical chemistry methods development
- CRISPR and Genetic Engineering
- Parasite Biology and Host Interactions
- Parasites and Host Interactions
- Pharmaceutical and Antibiotic Environmental Impacts
- Pesticide Residue Analysis and Safety
- Synthesis and Catalytic Reactions
- Synthesis and biological activity
Universidad Autónoma de Nuevo León
2016-2025
Pontificia Universidad Católica de Chile
2014-2016
Rede de Química e Tecnologia
2015
A set of new aryloxy-quinones were synthesized and evaluated<italic>in vitro</italic>against the epimastigote form of<italic>Trypanosoma cruzi</italic>and their unspecific cytotoxicity was tested on murine macrophages J-774 cells.
To develop novel chemotherapeutic alternatives for the treatment of Chagas disease, in this study, a set new amino naphthoquinone derivatives were synthesised and evaluated vitro on epimastigote trypomastigote forms Trypanosoma cruzi strains (NINOA INC-5) J774 murine macrophages. The design considered incorporation nitrogenous fragments with different substitution patterns present compounds activity T. cruzi, and, thus, 19 simple manner. Compounds 2e 7j showed lowest IC50 values (0.43 µM...
Background/Objectives: α-carbonic anhydrase (α-TcCA) has emerged as a promising drug target in T. cruzi, the causative agent of Chagas disease Americas. Sulfonamides, known inhibitors CAs, bind to zinc ion on enzyme’s active site. This study proposes repositioning sulfonamide-based drugs identify new trypanocidal agents. Method: Ligand-based virtual screening and molecular docking analysis were performed FDA-approved targeting α-TcCA. These compounds evaluated vitro ex vivo against A1 NINOA...
Continuing with a program to develop new quinone derivatives as biologically active compounds, we designed and synthesized series of aryloxy-quinones, which were evaluated in vitro against Trypanosoma cruzi epimastigote form. Chemical modifications three specific moieties on the aryloxy-quinone core considered for developing anti-T. agents. The majority our quinones showed higher potency (IC50 values <0.70 µM) than nifurtimox, known pharmaceutical used baseline drug 7.00 µM); however, only...
A set of aryloxy-quinones, previously synthesized and evaluated against Trypanosoma cruzi epimastigotes cultures, were found more potent selective than nifurtimox. One the possible mechanisms trypanocidal activity these quinones could be inhibition trypanothione reductase (TR). Considering that glutathione (GR) is equivalent TR in humans, biochemical, kinetic, molecular docking studies GR envisaged compared with cytotoxic data a aryloxy-quinones. Biochemical assays indicated three...
Antimicrobials are routinely used in human and veterinary medicine. With repeated exposure, antimicrobials promote antibiotic resistance, which poses a threat to public health. In this study, we aimed determine the susceptibility patterns, virulence factors, phylogroups of E. coli isolates during killing process bovine slaughterhouse. We analyzed 336 samples (from water, surfaces, carcasses, feces), 83.3% (280/336) were positive for coli. The most common phenotypic resistances that detected...
The CRISPR-Cas [clustered regularly interspaced short palindromic repeats and the CRISPR-associated genes (Cas)] system provides defense mechanisms in bacteria archaea vs. mobile genetic elements (MGEs), such as plasmids bacteriophages, which can either be harmful or add sequences that provide virulence antibiotic resistance. Staphylococcus aureus is a Gram-positive bacterium could etiological agent of important soft tissue infections lead to bacteremia sepsis. role S. not completely...
Chagas disease, a condition caused by Trypanosoma cruzi, is an endemic disease in Latin American countries that affects approximately eight million people worldwide. It continuing public health problem. As nifurtimox and benznidazole are the two pharmacological treatments currently used to treat it, present research proposes new therapeutic alternatives. Previous studies conducted on naphthoquinone derivatives have found interesting trypanocidal effects epimastigotes, with molecules...
Chagas disease has an ineffective drug treatment despite efforts made over the last four decades. The carbonic anhydrase of Trypanosoma cruzi (α-TcCA) emerged as interesting target for design new antiparasitic compounds due to its crucial role in parasite processes.
In this study, the aim was to identify and quantify antibiotic residues in pork meat samples of supermarkets butcher shops two main cities northeast Mexico, using Ultra-Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS). The results shown seven detected samples. Ampicillin with a higher positive rate (>59%) shops. Tetracycline sulfamethazine had high (>25%). Finally, quantification antibiotics that exceed minimum limits (MRL). study suggests an inadequate management food industry...
An organic salt and four metal complexes derived from azole were evaluated against embryonated Toxocara canis eggs (TCE). The new salt, (LH)+(FeCl4)-, where L = 3,5-bis(3,5-dimethylpyrazole-1-ylmethyl)toluene (5), a potential environmental disinfectant, was isolated as an air-stable yellow solid characterized by elemental analysis, electrical conductivity, mass spectrometry, infrared ultraviolet/visible spectroscopy. In addition, the structure of 5 determined single-crystal X-ray...
Abstract In continuation our effort to research the chemical space of aryloxy-naphthoquinones as potential anti-Chagas agents, we synthesized nine derivatives and these compounds were evaluated in vitro against epimastigote trypomastigote forms Mexican strains Trypanosoma cruzi ( T. ). Most are highly active (IC 50 < 1.0 µM) compared reference drug benznidazole (Bzn). Then on trypomastigotes, which is showing better potency results than Bzn for 3b 3g . addition, cytotoxicity was...