A5007471117- Mesenchymal stem cell research
- Lymphatic System and Diseases
- Cell Adhesion Molecules Research
- Electrospun Nanofibers in Biomedical Applications
- Cancer Cells and Metastasis
- Wound Healing and Treatments
- Immune cells in cancer
- Lymphatic Disorders and Treatments
- Lung Cancer Treatments and Mutations
- Adipokines, Inflammation, and Metabolic Diseases
- IL-33, ST2, and ILC Pathways
- Chemokine receptors and signaling
- Lung Cancer Diagnosis and Treatment
- Angiogenesis and VEGF in Cancer
- Systemic Lupus Erythematosus Research
- Inflammation biomarkers and pathways
- Oral Health Pathology and Treatment
- Rheumatoid Arthritis Research and Therapies
- Lung Cancer Research Studies
- Biomarkers in Disease Mechanisms
AstraZeneca (United Kingdom)
2018-2021
University of Birmingham
2017-2019
Rheumatology Consultants
2019
StemCells (United States)
2018
Abstract Two major monocyte subsets, CD14+CD16− (classical) and CD14+/dimCD16+ (nonclassical/intermediate), have been described. Each has different functions ascribed in its interactions with vascular endothelial cells (EC), including migration promoting inflammation. Although subpopulations studied isolated systems, their influence on EC the course of inflammation ignored. In this study, using unstimulated or cytokine-activated EC, we observed significant differences recruitment, migration,...
Synovial fibroblasts actively regulate the inflammatory infiltrate by communicating with neighbouring endothelial cells (EC). Surprisingly, little is known about how development of rheumatoid arthritis (RA) alters these immunomodulatory properties. We examined effects phase RA and disease outcome (resolving vs persistence) on fibroblast crosstalk EC regulation lymphocyte recruitment.Fibroblasts were isolated from patients without synovitis, resolving arthritis, very early (VeRA; symptom ≤12...
Advanced non-small-cell lung cancer (NSCLC) patients with EGFR T790M-positive tumours benefit from osimertinib, an epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI). Here we show that the size of clone impacts response to osimertinib. T790M subclonality, as assessed by a retrospective NGS analysis 289 baseline plasma ctDNA samples advanced NSCLC AURA3 phase III trial, is associated shorter progression-free survival (PFS), both in osimertinib and chemotherapy-treated...
Abstract Chronic inflammation is associated with formation of ectopic fat deposits that might represent damage-induced aberrant mesenchymal stem cell (MSC) differentiation. Such are increased levels inflammatory infiltrate and poor prognosis. Here we tested the hypothesis differentiation from MSC to adipocytes in inflamed tissue contribute chronicity through loss immunomodulatory function. We assessed effects adipogenic isolated bone marrow or adipose on their capacity regulate neutrophil...
Mesenchymal stromal cells (MSC) up-regulate podoplanin at sites of infection, chronic inflammation, and cancer. We investigated the functional consequences expression on migratory potential MSC their interactions with circulating platelets. Expression significantly enhanced migration compared to lacking podoplanin. Rac-1 inhibition altered membrane localisation in turn reduced migration. Blocking activity had no effect podoplanin, indicating it was responsible for regulation through When...
We investigated the adhesive behavior of mesenchymal stem cells (MSC) in blood, which might influence their fate when infused as therapy. Isolated human bone marrow MSC (BMMSC) or umbilical cord (UCMSC) adhered efficiently from flow to matrix proteins, collagen, fibronectin, but did not adhere endothelial selectins. However, suspended BMMSC no longer while UCMSC along with many aggregated platelets. Neither fibronectin flowing although surface become coated a platelet monolayer. induced...
BACKGROUND:Mesenchymal stem cells (MSC) are used in therapy, often by injection into the blood. OBJECTIVE:We aimed to compare adhesive and migratory properties of MSC from umbilical cords (UCMSC), bone marrow (BMMSC) or trabecular (TBMSC), which might influence delivery injured tissue. METHODS:MSC were perfused through glass capillaries coated with matrix proteins, collagen fibronectin, albumin. Adherent counted microscopically their spreading analysed over time. migration 8 μm pore filters...
<h3>Career situation of first and presenting author</h3> Young investigator. <h3>Introduction</h3> Within the rheumatoid joint, mesenchymal stromal cells (MSC) up-regulate podoplanin with unknown consequences for disease pathogenesis. The function has been linked to enhanced migratory potential interactions platelets. However, it is unclear how these two cell types interact one another, given that MSC platelets are usually located in different anatomical compartments (tissue vs blood...