A5062386785- Erythrocyte Function and Pathophysiology
- Lung Cancer Research Studies
- Hearing, Cochlea, Tinnitus, Genetics
- Magnesium Alloys: Properties and Applications
- Connexins and lens biology
- Lung Cancer Treatments and Mutations
- Bone Tissue Engineering Materials
- Enzyme Structure and Function
- Advanced oxidation water treatment
- Corrosion Behavior and Inhibition
- Microbial Metabolic Engineering and Bioproduction
- Synthetic Aperture Radar (SAR) Applications and Techniques
- RNA Research and Splicing
- Geophysical Methods and Applications
- Diabetes Treatment and Management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Zebrafish Biomedical Research Applications
- Ferroelectric and Piezoelectric Materials
- Cognitive Radio Networks and Spectrum Sensing
- Sparse and Compressive Sensing Techniques
- Autophagy in Disease and Therapy
- Gynecological conditions and treatments
- Genomics, phytochemicals, and oxidative stress
- Ultrasound and Hyperthermia Applications
- Advancements in Battery Materials
Shandong University
2016-2024
Advanced Medical Research Institute
2024
Chengdu University of Traditional Chinese Medicine
2024
China University of Mining and Technology
2023
Qilu Hospital of Shandong University
2023
Tsinghua University
2022
Center for Life Sciences
2022
Shandong First Medical University
2017-2022
Shandong Provincial QianFoShan Hospital
2022
Shandong Tumor Hospital
2017-2021
The mechanically activated Piezo channel plays a versatile role in conferring mechanosensitivity to various cell types. However, how it incorporates its intrinsic and cellular components effectively sense long-range mechanical perturbation across remains elusive. Here we show that channels are biochemically functionally tethered the actin cytoskeleton via cadherin-β-catenin mechanotransduction complex, whose significantly impairs Piezo-mediated responses. Mechanistically, adhesive...
5-Aminolevulinic acid (ALA), a nonprotein amino involved in tetrapyrrole synthesis, has been widely applied agriculture, medicine, and food production. Many engineered metabolic pathways have constructed; however, the production yields are still low. In this study, several 5-aminolevulinic synthases (ALASs) from different sources were evaluated compared with respect to their ALA capacities an Corynebacterium glutamicum CgS1 strain that can accumulate succinyl-coenzyme A (CoA)....
There is a constant shortage of red blood cells (RBCs) from sufficiently matched donors for patients who need chronic transfusion. Ex vivo expansion and maturation human erythroid precursors (erythroblasts) the or optimally could represent potential solution. Proliferating erythroblasts can be expanded umbilical cord mononuclear (CB MNCs) ex 10(6)-10(7)-fold (in ~50 days) before proliferation arrest reaching sufficient number broad application. Here, we report that ectopic expression three...
Spectrum sensing is one of the key technologies in field cognitive radio, which has been widely studied. Among all methods, energy detection most popular because its simplicity and no requirement any prior knowledge signal. In case low signal-to-noise ratio (SNR), traditional double-threshold method employs fixed thresholds there result when between high thresholds, leads to poor performance such as lower probability longer spectrum time. To address these problems, we proposed an adaptive...
FOXM1 is a potent oncogenic transcription factor essential for cancer initiation, progression, and drug resistance. regulatory network major predictor of adverse outcomes in various human cancers. Inhibition function potential strategy treatment. In this study, we performed structure-based silico screening to discover small molecules targeting the DNA-binding domain (DBD). Compound XST-20 was identified effectively suppress transcriptional activities inhibit ovarian cell proliferation....
Conventional electronic rules, including Jellium and Wade–Mingos rules so on, have long been successfully dedicated to design superatoms. These however, rely on altering the intrinsic properties, for example, compositions or number of valence electrons, clusters, which is relatively complicated inconvenient manipulate, especially in experiments. Herein, by employing density functional theory calculations, oriented external electric field (OEEF) was demonstrated possess capability precisely...
The recombinase RAD51 catalyzes the DNA strand exchange reaction in homologous recombination (HR) during both mitosis and meiosis. However, physiological role of spermatogenesis remains unclear since null mutation is embryonic lethal mice. In this study, we generated a conditional knockout mouse model to study spermatogenesis. Conditional disruption germ cells by Vasa-Cre led spermatogonial loss Sertoli cell-only syndrome. Furthermore, tamoxifen-inducible UBC-CreERT2 confirmed that deletion...
Abstract Regulation of alternative splicing (AS) enables a single transcript to yield multiple isoforms that increase transcriptome and proteome diversity. Here, we report spliceosome component Usp39 plays role in the regulation hepatocyte lipid homeostasis. We demonstrate expression is downregulated hepatic tissues non-alcoholic fatty liver disease (NAFLD) steatohepatitis (NASH) subjects. Hepatocyte-specific deletion mice leads increased accumulation, spontaneous steatosis impaired...
Abstract Cholangiocarcinomas (CCAs) are rare but aggressive tumors of the bile ducts. CCAs often diagnosed at an advanced stage and respond poorly to current conventional radiotherapy chemotherapy. High mobility group A1 (HMGA1) is architectural transcription factor that overexpressed in multiple malignant tumors. In this study, we showed expression HMGA1 frequently elevated high gene associated with a poor prognosis. Functionally, promotes CCA cell proliferation/invasion xenograft tumor...
Transmembrane channel-like (TMC) proteins are a highly conserved ion channel family consisting of eight members (TMC1–TMC8) in mammals. TMC1/2 components the mechanotransduction hair cells, and mutations cause deafness humans mice. However, physiological roles other TMC remain largely unknown. Here, we show that Tmc7 is specifically expressed testis it required for acrosome biogenesis during spermatogenesis. −/− mice exhibited abnormal sperm head, disorganized mitochondrial sheaths, reduced...
Transmembrane channel-like (Tmc) proteins are a highly conserved ion channel family consisting of eight members (TMC1–TMC8) in mammals. TMC1/2 components the mechanotransduction hair cells, and mutations cause deafness humans mice. However, physiological roles other TMC remain largely unknown. Here, we show that Tmc7 is specifically expressed testis it required for acrosome biogenesis during spermatogenesis. −/− mice exhibited complete male infertility due to abnormal sperm morphology,...
Transmembrane channel-like (TMC) proteins are a highly conserved ion channel family consisting of eight members (TMC1–TMC8) in mammals. TMC1/2 components the mechanotransduction hair cells, and mutations cause deafness humans mice. However, physiological roles other TMC remain largely unknown. Here, we show that Tmc7 is specifically expressed testis it required for acrosome biogenesis during spermatogenesis. −/− mice exhibited abnormal sperm head, disorganized mitochondrial sheaths, reduced...
Transmembrane channel-like (TMC) proteins are a highly conserved ion channel family consisting of eight members (TMC1–TMC8) in mammals. TMC1/2 components the mechanotransduction hair cells, and mutations cause deafness humans mice. However, physiological roles other TMC remain largely unknown. Here, we show that Tmc7 is specifically expressed testis it required for acrosome biogenesis during spermatogenesis. −/− mice exhibited abnormal sperm head, disorganized mitochondrial sheaths, reduced...