A5030534609- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Radioactive contamination and transfer
- Cancer Research and Treatments
- Radioactivity and Radon Measurements
- Epigenetics and DNA Methylation
- Nuclear Issues and Defense
- Cancer-related Molecular Pathways
- Amino Acid Enzymes and Metabolism
- Nuclear and radioactivity studies
- Genetics, Bioinformatics, and Biomedical Research
- RNA and protein synthesis mechanisms
- PI3K/AKT/mTOR signaling in cancer
- Metabolism, Diabetes, and Cancer
- RNA Research and Splicing
- Monoclonal and Polyclonal Antibodies Research
- Galectins and Cancer Biology
- Cancer-related gene regulation
- Mitochondrial Function and Pathology
- Economic and Technological Developments in Russia
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Peroxisome Proliferator-Activated Receptors
- Cellular transport and secretion
- RNA regulation and disease
Huntsman Cancer Institute
2024
University of Utah
2024
Research and Production Association Typhoon
2020-2023
Memorial Sloan Kettering Cancer Center
2015-2022
Roshydromet
2019-2021
Institute of Psychology
2018
Kettering University
2016
Howard Hughes Medical Institute
2008-2013
Brigham and Women's Hospital
2011-2013
Harvard University
2007-2013
During all stages of tumor progression, cancer cells are subjected to inappropriate extracellular matrix environments and must undergo adaptive changes in order evade growth constraints associated with the loss attachment. A gain function screen for genes that enable proliferation independently anchorage identified a cell adhesion molecule PVRL4 (poliovirus-receptor-like 4), also known as Nectin-4. promotes anchorage-independence by driving cell-to-cell attachment matrix-independent integrin...
An inadequate supply of amino acids leads to accumulation uncharged tRNAs, which can bind and activate GCN2 kinase reduce translation. Here, we show that glutamine-specific tRNAs selectively become when extracellular acid availability is compromised. In contrast, all other retain charging their cognate in a manner dependent upon intact lysosomal function. addition activation reduced total translation, the tRNA Gln amino-acid-deprived cells also specific depletion proteins containing...
Tumor cells adapt to nutrient-limited environments by inducing gene expression that ensures adequate nutrients sustain metabolic demands. For example, during amino acid limitations, ATF4 in the response induces of asparagine synthetase (ASNS), which provides for biosynthesis. Acute lymphoblastic leukemia (ALL) are sensitive depletion, and administration depletion enzyme l-asparaginase is an important therapy option. ASNS can counterbalance treatment mitigating nutrient stress. Therefore,...
Antibody discovery platforms have become an important source of both therapeutic biomolecules and research reagents. Massively parallel DNA sequencing can be used to assist antibody selection by comprehensively monitoring libraries during selection, thus greatly expanding the power these systems. We therefore constructed a rationally designed, fully defined single-chain variable fragment (scFv) library analysis platform optimized for with short-read deep sequencing. Sequence-defined...
Significance Cells can respond to starvation by up-regulating stress responses that promote the recycling or scavenging of essential nutrients. We identify a response allows cells store amino acid leucine within lysosomes when extracellular acids are scarce. This “storage” sequester an in support protein synthesis. find numerous trafficked through even concentrations high, suggesting constitutive flux is related starvation-induced storage.
Abstract Aims Cardiomyopathy and arrhythmias can be severe presentations in patients with inherited defects of mitochondrial long-chain fatty acid β-oxidation (FAO). The pathophysiological mechanisms that underlie these cardiac abnormalities remain largely unknown. We investigated the molecular adaptations to a FAO deficiency heart using acyl-CoA dehydrogenase (LCAD) knockout (KO) mouse model. Methods results observed enrichment amino metabolic pathways ATF4 target genes among upregulated...
A challenge of targeting glutamine metabolism in cancer is that tumor cells develop various strategies to adapt limitation. We found asparagine plays a critical role supporting protein synthesis during starvation, highlighting possible approach optimize the therapeutic efficacy cancer.
Significance Cell proliferation control is central to tumor suppression. We previously identified hundreds of suppressors tumorigenesis and/or (STOP) genes that restrain normal cell proliferation. Here we show one such STOP gene, phosphatase and actin regulator 4 ( PHACTR4 ), acts prevent tumorigenesis. Phactr4 suppresses transformation in vitro vivo. significantly mutated or downregulated several cancers, reintroduction limits growth cells from these cancers. Thus, our studies provide...
The current paper shows the results of study on intentional structure everyday common communication, psychological consulting practice, scientific discussions and both interactive radio TV programs. main method is Intent-analysis. It based expert estimation that focuses defining speech intentions related to interlocutors’ orientations their partners, interaction effects speech. typical elements an a dialogue its modifications in certain communicative context are represented. An includes...