A5035456742- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Amino Acid Enzymes and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA regulation and disease
- Cerebrospinal fluid and hydrocephalus
- Retinal Development and Disorders
- Memory and Neural Mechanisms
- Molecular Sensors and Ion Detection
- Ion channel regulation and function
- Receptor Mechanisms and Signaling
- Mitochondrial Function and Pathology
- GABA and Rice Research
- Ion Transport and Channel Regulation
- MicroRNA in disease regulation
- Fetal and Pediatric Neurological Disorders
- Single-cell and spatial transcriptomics
- Immune cells in cancer
- Pluripotent Stem Cells Research
- Traumatic Brain Injury and Neurovascular Disturbances
Nova Southeastern University
2025
University of Pennsylvania
2016-2025
Philadelphia University
2017-2025
Children's Hospital of Philadelphia
2016-2025
Translational Therapeutics (United States)
2023-2025
Center for Research and Advanced Studies of the National Polytechnic Institute
2011-2017
Instituto Politécnico Nacional
2011-2017
Virginia Commonwealth University Medical Center
2014
Abstract In mice engineered to express enhanced green fluorescent protein (eGFP) under the control of entire glutamate transporter 1 (GLT1) gene, eGFP is found in all ‘adult’ cortical astrocytes. However, when 8.3 kilobases human GLT1/EAAT2 promoter used expression tdTomato (tdT), tdT only a subpopulation these eGFP-expressing The have been define mechanisms transcriptional regulation using astrocytes cultured from cortex 1–3 day old mice. Using same cultures, we were never able induce +...
Abstract Glutamate, the major excitatory transmitter in vertebrate brain, is removed from synaptic cleft by a family of sodium‐dependent glutamate transporters profusely expressed glial cells. Once internalized, it metabolized glutamine synthetase to and released space through neutral amino acid carriers N System ( SNAT3 /slc38a3/ SN1 , SNAT5 /slc38a5/ SN2 ). Glutamine then taken up neurons completing so‐called glutamate/glutamine shuttle. Despite fact that this coupling was described...
Signaling via the major excitatory amino acid glutamate has been implicated in regulation of various aspects biology oligodendrocytes, myelinating cells central nervous system (CNS). In this respect, oligodendrocyte lineage have described to express a variety glutamate‐responsive transmembrane proteins including sodium‐dependent transporters. The latter well characterized mediate clearance from extracellular space. However, there is increasing evidence that they also glutamate‐induced...
Neuron-secreted factors induce astrocytic expression of the glutamate transporter, GLT-1 (excitatory amino acid transporter 2). In addition to their elaborate anatomic relationships with neurons, astrocytes also have processes that extend and envelop vasculature. Although previous studies demonstrated brain endothelia contribute astrocyte differentiation maturation, effects on not been examined. this study, we tested hypothesis by co-culturing from mice utilize non-coding elements gene...
Glu (glutamate), the excitatory transmitter at main signalling pathway in retina, is critically involved changes protein repertoire through activation of cascades, which regulate synthesis transcriptional and translational levels. Activity-dependent differential gene expression by related to ionotropic metabotropic receptors; however, recent findings suggest involvement Na + -dependent transporters this process. Within uptake aimed replenishment releasable pool, for prevention excitotoxicity...
Aquaporin-4 (AQP4) is a water channel protein that links the astrocytic endfeet to blood-brain barrier (BBB) and regulates potassium homeostasis in brain, as well glymphatic clearance of waste products would otherwise potentiate neurological diseases. Recently, translational readthrough was shown generate C-terminally extended variant AQP4, known AQP4x, which preferentially localizes around BBB through interaction with scaffolding α-syntrophin, loss AQP4x disrupts from brain. To investigate...
Abstract Astrocytes have essential roles in central nervous system (CNS) health and disease. During development, immature astrocytes show complex interactions with neurons, endothelial cells, other glial cell types. Our work that of others shown these are important for astrocytic maturation. However, whether how cells together to control this process remains poorly understood. Here, we test the hypothesis cooperative neurons promote were cultured alone, or a combination both. This was...
Aquaporin-4 (AQP4) is a water channel protein that links astrocytic endfeet to the blood-brain barrier (BBB) and regulates potassium homeostasis in brain, as well glymphatic clearance of waste products would otherwise potentiate neurological diseases. Recently, translational readthrough was shown generate C-terminally extended variant AQP4, known AQP4x, preferentially localizes around BBB through interaction with scaffolding α-syntrophin, loss AQP4x disrupts from brain. To investigate...