Summary Introduction The day of the week or time that surgery is performed may influence postoperative mortality complications. We aimed to examine whether under general anaesthesia after‐hours was associated with increased rates and morbidity, compared in‐hours. Methods This population‐based cohort study obtained data for patients who underwent from National Health Insurance Service South Korea. Propensity score‐matched groups either in‐hours (weekdays between 9.00 18.00) 18.00 09.00 on a...

Abstract Background The relationship between socioeconomic status and the risk of contracting coronavirus disease (COVID-19) remains controversial. We aimed to investigate whether affected COVID-19 in South Korean population. Methods NHIS-COVID-19 database cohort was used this population-based study. collected data patients who were diagnosed January 1, 2020 June 4, those control income levels all individuals as February extracted, study participants classified into four groups based on...

Propofol-based total intravenous anesthesia (TIVA) has been reported to improve long-term outcome following cancer surgery, when compared with inhalation agents. However, such investigational reports are still controversial, and no studies have conducted in relation non-small cell lung (NSCLC) surgery. The present study aimed compare the favorable effects of TIVA versus agents on recurrence-free survival overall after curative resection NSCLC. This retrospective cohort examined medical...

This study aimed to examine the prognostic value of C-reactive protein (CRP)/albumin (ALB) ratio among patients who were admitted intensive care unit (ICU) in predicting 30-day mortality rate. retrospective cohort was conducted by examining medical records adult ICU at Seoul National University Bundang Hospital between 1 January 2012 and 31 December 2016. Data from 6,972 individuals included final analysis, 547 these (7.1%) died within 30 days after their admission. The multivariable Cox...

We aimed to investigate the prevalence and factors associated with long-term opioid use among patients chronic non-cancer pain (CNCP).We extracted data from National Health Insurance Service (NHIS) database in South Korea. As a nationwide database, NHIS contains information regarding all disease diagnoses prescriptions for any drug and/or procedures. A total of 2.5% adult (≥20 years age) who were diagnosed musculoskeletal diseases CNCP 2010 2019 selected using stratified random sampling...

Prophylactic fluid preloading before spinal anesthesia has been a routine procedure to prevent maternal hypotension during cesarean delivery. Unlike colloid, timing of infusion crystalloid may be important because its short stay in intravascular space. We hypothesized that loading just after intrathecal injection compared preload would more effective preventing hypotension. In this prospective controlled study, sixty parturients were randomized receive 15 ml/kg (preload group) or (coload...

Background Sevoflurane is widely used in paediatric anaesthesia but frequently causes emergence agitation ( EA ). This study evaluated whether limiting the sevoflurane concentration by combining remifentanil with reduced incidence of . Methods Eighty‐four preschool children scheduled for adenotonsillectomy were randomly assigned to either or group. In group, was induced thiopental, rocuronium, and 1% sevoflurane. It maintained sevoflurane, 60% nitrous oxide oxygen, a continuous infusion...

The impact of underlying chronic respiratory diseases (CRDs) on the risk and mortality patients with coronavirus disease 2019 (COVID-19) remains controversial. We aimed to investigate effects CRDs COVID-19 among population in South Korea.The NHIS-COVID-19 database Korea was used for data extraction this population-based cohort study. Chronic obstructive pulmonary (COPD), asthma, interstitial lung (ILD), cancer, due external agents, sleep apnea (OSA), tuberculosis lungs (TB) were considered...

Healthy life expectancy is a well-recognized indicator for establishing health policy goals used in Korea's Health Plan. This study aimed to explore Koreans' healthy and its gender, income, regional disparities from 2008 2020.

C-reactive protein and albumin are associated with poor outcomes in critically ill patients. This study aimed to investigate the significance of protein/albumin (CRP/ALB) ratio as a novel prognostic factor for 30-day or 1-year mortality after admission postoperative intensive care unit (ICU). retrospective was conducted by examining medical records patients aged 19 years older admitted ICU at tertiary hospital from January 2007 July 2016. included data on 11,832 analysis. The cut-off value...

The relationship between metformin therapy and the risk of coronavirus disease (COVID-19) has not been reported among patients with type 2 diabetes mellitus (DM). We aimed to investigate whether was associated incidence COVID-19 DM in South Korea.The National Health Insurance Service-COVID-19 cohort database, comprising from 1 January 2020 4 June 2020, used for this study. Among them, adult were included Metformin users defined as those who had prescribed continuous oral over a period ≥ 90...

Abstract Background The difference in survival outcomes between closed and open intensive care unit (ICU) designs with respect to trained intensivist coverage remains unknown. We aimed investigate whether is associated mortality critically ill patients admitted the ICU South Korea. Methods This population-based cohort study used nationwide registration data from enrolled all adult January 1, 2016, December 31, 2019. Patients, who were a hospital that employed intensivists, designated as...

Abstract In mice engineered to express enhanced green fluorescent protein (eGFP) under the control of entire glutamate transporter 1 (GLT1) gene, eGFP is found in all ‘adult’ cortical astrocytes. However, when 8.3 kilobases human GLT1/EAAT2 promoter used expression tdTomato (tdT), tdT only a subpopulation these eGFP-expressing The have been define mechanisms transcriptional regulation using astrocytes cultured from cortex 1–3 day old mice. Using same cultures, we were never able induce +...

Objective Dexmedetomidine is known to reduce the incidence of emergence agitation, which a common complication after inhalational anesthesia like sevoflurane or desflurane in children. However, dose dexmedetomidine used for this purpose reported variously and most effective not known. In study, we tried find agitation children undergoing strabismus surgery without complications oculocardiac reflex (OCR) postoperative vomiting. Methods We randomized 103 pediatric patients aged 2–6 years...

Abstract This retrospective cohort study investigated the association between in-hospital survival and two-dimensional (2D) echocardiography within 24 hours after return of spontaneous circulation (ROSC) in patients who underwent cardiopulmonary resuscitation (ICPR) arrest (IHCA). The 2D-echo non-2D-echo groups comprised eligible transthoracic 2D performed by cardiology team ROSC those did not, respectively. After propensity score (PS) matching, 142 284 groups, respectively, were included. A...

We aimed to investigate whether statin therapy is associated with the incidence of coronavirus disease 2019 (COVID-19) among South Korean population. In addition, we examined affects hospital mortality COVID-19 patients. The National Health Insurance Service (NHIS)-COVID-19 database in Korea was used for data extraction this population-based cohort study. A total 122,040 adult individuals, 22,633 (18.5%) group and 101,697 (91.5%) control group, were included analysis. Among them, 7780 (6.4%)...

Abstract We aimed to examine the association between opioid use and development of dementia in patients with chronic non-cancer pain South Korea. Data were extracted from National Health Insurance Service database Adult diagnosed musculoskeletal diseases 2010 2015 included analysis. Patients who prescribed opioids regularly continuously for ≥ 90 days classified as users. In total, 1,261,682 final analysis, whom 21,800 (1.7%) From January 1, 2016 December 31, 2020, 35,239 (2.8%) newly...

Obesity is a major public health problem worldwide and associated with increased morbidity mortality. However, studies have shown that obesity has sepsis-related mortality benefits. We aimed to determine whether there an improved survival rate in patients South Korea. included data from 77,810 adults sepsis between 1 January 2013 31 December 2020, extracted the National Health Insurance Service database The underwent standard examinations within year before sepsis, body mass index (BMI)...

Background Dexmedetomidine has a sedative analgesic property without respiratory depression. This study evaluated the efficacy of dexmedetomidine as an appropriate drug for monitored anesthesia care (MAC) in outpatients undergoing cataract surgery on both eyes compared with combination propofol and alfentanil. Methods Thirty-one eligible patients were randomly divided into two groups first operation day. was administered group D at 0.6 µg/kg/h, alfentanil infused concomitantly P rate 2...

The vasovagal response is characterized by an inappropriate combination of bradycardia and paradoxical vasodilation. During a general or neuraxial anesthesia-induced sympathectomy, sudden vagal activation and/or acute reduction in sympathetic tone can cause serious responses. Neuraxial anesthesia for Cesarean section may trigger response, due to multiple risk factors; high block, hemorrhage, aortocarval compression, peritoneal manipulation, emotional stress. A 39-year-old pregnant woman, at...