A5043477229- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Asthma and respiratory diseases
- Cardiac Ischemia and Reperfusion
- Neurological Disorders and Treatments
- Allergic Rhinitis and Sensitization
- Neurological Disease Mechanisms and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cutaneous lymphoproliferative disorders research
- Circadian rhythm and melatonin
- Phytoplasmas and Hemiptera pathogens
- Poxvirus research and outbreaks
- Platelet Disorders and Treatments
- Anesthesia and Sedative Agents
- Fermentation and Sensory Analysis
- Autoimmune Bullous Skin Diseases
- Peripheral Artery Disease Management
- Parasitic Diseases Research and Treatment
- Infectious Diseases and Mycology
- Contact Dermatitis and Allergies
- Nail Diseases and Treatments
- Parasites and Host Interactions
- Anesthesia and Neurotoxicity Research
- Hemodynamic Monitoring and Therapy
University of Pecs
2010-2025
Jahn Ferenc Dél-Pesti Kórház és Rendelőintézet
2001
Abstract Imiquimod (IMQ)-induced skin inflammation is currently the most widely accepted psoriasis animal model, however, it features several limitations. We have modified IMQ-model to minimize its systemic effects towards effectively maintaining characteristic reactions. The original protocol (OP) uses 62.5 mg Aldara cream (or vaseline) on shaved back of mice for 4 days. In contrast, in our (MP) 25 and vaseline are applied simultaneously separate Finn chambers over dorsal mice. both OP MP...
Antiphospholipid antibody (aPL)-induced activation of the mTOR (mammalian target rapamycin) signaling pathway in endothelial cells plays a role pathogenesis vascular lesions antiphospholipid syndrome (APS). However, there are no data on whether this mechanism also contributes to development skin ulcers commonly observed APS. We investigated specimens from aPL-positive and aPL-negative patients with leg ulcers. Patients who had primary or secondary APS detectable aPLs were included study....
Psoriasis is a chronic inflammatory disease with unmet medical needs. To clarify potential therapeutic targets, different animal models have been developed. In the current study, imiquimod-induced psoriasiform dermatitis was used for monitoring changes in skin thickness, transepidermal water loss, body weight, blood perfusion and drug permeability topical cream formulation of caffeine, both wild type knock out mice. Morphological characterization control diseased tissues performed by...
Here, we present the findings of an investigation involving two male siblings with juvenile total tooth loss, early-onset chronic leg ulcers, and autoimmune thyroiditis, as well focal segmental glomerulosclerosis associated pulmonary emphysema in one diabetes mellitus other. The clinical picture lupus anticoagulant, cryoglobulin, cold agglutinin positivity suggested diagnosis antiphospholipid syndrome. Flow cytometry analysis showed immunophenotypes consistent immune dysregulation: a low...
Psoriasis is a systemic inflammatory skin disorder that can be associated with sleep disturbance and negatively influence the daily rhythm. The link between pathomechanism of psoriasis circadian rhythm has been suggested by several previous studies. However, there are insufficient data on altered clock mechanisms in to prove these theories. Therefore, we investigated expression core genes human psoriatic lesional non-lesional adult low calcium temperature (HaCaT) keratinocytes after...
After revascularization of an acute arterial occlusion the development a serious ischaemic-reperfusion injury is menacing challenge and hard task in peripheral vascular surgery. A whale evidences point to oxidative stress, as important trigger, complex chain events leading reperfusion injury. In present study authors aimed examine stress parameters, antioxidant-prooxidant state leukocyte adhesion molecules (CD11a CD18) expression following surgery lower limb.10 patients were examined...
Abstract The expanding number of research studies utilizing the imiquimod‐induced psoriasiform dermatitis model attests to usefulness this procedure. Advantages include rapid development skin response and cost‐effectiveness. A major limitation is that application imiquimod cream over large areas skin, as well licking ingestion cream, may lead severe systemic inflammation, which can cause a general decline in health, splenomegaly, death. In protocol, Finn chambers are used localize small area...
Members of the Malassezia genus are lipophilic fungi that closely adapted to milieu skin areas rich in sebaceous glands. They most important fungal elements adult microbiome, with colonization starting immediately after birth. In recent years, their role pathogenesis many diseases has been suggested, however, data regarding actual function etiology each disease contradictory. our report, we would like present complex immunological mechanisms associated species, as well aspects related...
The authors present a case of 78-year-old man, who presented with arteritis temporalis like symptoms. In his previous laboratory findings elevated eosinophil count was seen, imaging studies ruled out inflammatory diseases and malignancy. During the surgical diagnostic biopsy thin white worm removed, microscopically Dirofilaria repens diagnosed. According to patient’s history, an infected mosquito bite is most likely while hiking along Drava River, host animal could be golden jackal. briefly...
Abstract We developed a modified imiquimod (IMQ)-induced dermatitis protocol (Horvath et al, Scientific Reports 2019) using Finn chambers to minimize the unwanted systemic side effects of this widely used psoriasis animal model. It enables perform prolonged treatment in self-control way as well. In present study we investigate long-term application IMQ localized 20 mg Aldara cream (5% IMQ) or vaseline were applied two on dorsal skin Balb/c mice during first 4 days experiment and every second...