A5026414014- Hepatitis C virus research
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- Monoclonal and Polyclonal Antibodies Research
- Infectious Encephalopathies and Encephalitis
- Tuberculosis Research and Epidemiology
- Synthesis and biological activity
- Computational Drug Discovery Methods
- Endoplasmic Reticulum Stress and Disease
- Click Chemistry and Applications
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Infectious Diseases and Tuberculosis
- Nanoplatforms for cancer theranostics
- Phytochemicals and Antioxidant Activities
- Protein Structure and Dynamics
- Viral Infections and Vectors
- Mycobacterium research and diagnosis
- Moringa oleifera research and applications
- Alcohol Consumption and Health Effects
- Cancer Research and Treatments
- Animal Virus Infections Studies
- Estrogen and related hormone effects
- Metabolomics and Mass Spectrometry Studies
- Biochemical and Molecular Research
University of KwaZulu-Natal
2017-2024
Centre for the AIDS Programme of Research in South Africa
2023-2024
South African Medical Research Council
2023-2024
Durban University of Technology
2018
Long COVID is an emerging public health threat, following swiftly behind the surges of acute infection over course COVID-19 pandemic. It estimated that there are already approximately 100 million people suffering from globally, 0.5 whom South African, and for our incomplete understanding condition has forestalled appropriate diagnosis clinical care. There several leading postulates complex, multi-mechanistic pathogenesis COVID. Patients with may present a diversity phenotypes, often...
Zearalenone is an estrogenic mycotoxin which a common food contaminant and has been implicated in increasing the incidence of carcinogenesis other reproductive health ailments through estrogen receptor alpha (ERα) pathway. Competitive ERα blockers such as 4-Hydroxytamoxifen (OHT), are synthetic FDA approved drugs which, albeit being effective anticancer agent, induces life altering side effects. For this reason, there increased interest use naturally occurring medicinal plant products...
<italic>In silico</italic>study investigating the interaction between HCV polymerase and selective covalent inhibitor, compound 47.
Heat shock protein 90 (Hsp90) is a crucial component in carcinogenesis and serves as molecular chaperone that facilitates maturation whilst protecting cells against temperature-induced stress. The function of Hsp90 highly dependent on adenosine triphosphate (ATP) binding to the N-terminal domain protein. Thus, inhibition through displacement ATP by means competitive with suitable organic molecule considered an attractive topic cancer research. Radicicol (RD) its derivative, resorcinylic...
Communicated by Ramaswamy H. Sarma
Introduction The TriAD study will assess the Xpert MTB/XDR (Xpert XDR; Cepheid) assay to detect tuberculosis (TB) drug resistance in sputum testing positive for TB rapidly triage and treat patients with a short all-oral treatment regimen. Methods analysis In this study, approximately 4800 MTB/RIF or Ultra MTB-positive (irrespective of rifampicin (RIF) (RR) status) from several clinical sites across South Africa, Nigeria Ethiopia be enrolled over 18–24 months followed-up 6 post-TB completion....
Accumulation of oxidative stress-induced lipid peroxidation products; 4-hydroxynonenal (4HNE) and 4-oxononenal (4ONE), inactivates the metabolic activity human liver aldehyde dehydrogenase 2 (ALDH2), an enzyme that converts acetaldehyde to carboxylic acids during alcohol metabolism. Previous reports showed 4HNE 4ONE covalently target catalytic Cys302 residue inactivate ALDH2, thereby preventing metabolism (ACE), its primary substrate. However, molecular basis these reactions remains elusive....