A5042818118- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Head and Neck Cancer Studies
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Immune cells in cancer
- Molecular Biology Techniques and Applications
- Genomic variations and chromosomal abnormalities
- Epigenetics and DNA Methylation
- Estrogen and related hormone effects
- Inflammatory Biomarkers in Disease Prognosis
- Phagocytosis and Immune Regulation
- Chromatin Remodeling and Cancer
- HER2/EGFR in Cancer Research
- Gene expression and cancer classification
- Cervical Cancer and HPV Research
- Drug Transport and Resistance Mechanisms
- Plant Disease Resistance and Genetics
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Stress, Anesthesia, and Immune Response
- Military History and Strategy
University of Tennessee Health Science Center
2020-2024
University of Wisconsin–Madison
2024
University of Mary Washington
2024
Wake Forest University
2024
Ducks Unlimited
2022-2024
Institut thématique Génétique, génomique et bioinformatique
2024
Center for Cancer Research
2020-2023
Bariatric surgery is a sustainable weight loss approach, including vertical sleeve gastrectomy (VSG). Obesity exacerbates tumor growth, while diet-induced impairs progression. It remains unknown how bariatric surgery-induced impacts cancer progression or alters response to therapy. Using pre-clinical model of obesity followed by VSG loss, breast and immune checkpoint blockade therapy were investigated. Weight weight-matched dietary intervention before engraftment protected against...
Bariatric surgery is associated with improved outcomes for several cancers, including breast cancer (BC), although the mechanisms mediating this protection are unknown. We hypothesized that elevated bile acid pools detected after bariatric may be factors contribute to BC outcomes. Patients greater expression of receptor FXR displayed survival in specific aggressive subtypes. a nuclear hormone activated by primary acids. Therefore, we posited activating using an established FDA-approved...
Abstract Tumor virus is one of the major causes human cancers, accounting for about 10-20% their global incidence. Viral oncogenes in tumor viruses promote tumorigenesis by deregulating host cancer genes. For instance, E6 and E7 proteins papillomavirus 16 (HPV16) induce degradation protein products suppressor genes (TSGs) including p53 pRb, to head neck squamous cell carcinoma (HNSCC). Therefore, it imperative understand how differences dosage viral affect biology. However, relative absolute...
Triple-negative breast cancer (TNBC) is an aggressive subtype with no targeted therapeutics. The luminal androgen receptor (LAR) constitutes 15% of TNBC and enriched for (AR) AR target genes. Here, we show that a cohort not only expresses at much higher rate (∼80%) but also splice variants (AR-SVs) (∼20%), further subclassifying LAR-TNBC. Higher AR-SV expression corresponding phenotypes are observed predominantly in specimens obtained from African American women. LAR interferon, Janus kinase...
Abstract High-throughput sequencing protocols such as RNA-seq have made it possible to interrogate the sequence, structure and abundance of RNA transcripts at higher resolution than previous microarray other molecular techniques. While many computational tools been proposed for identifying mRNA variation through differential splicing/alternative exon usage, challenges in its analysis remain. Here, we propose a framework unbiased robust discovery aberrant transcript structures using short...
Mononuclear phagocytes (MPs) play a crucial role in tissue homeostasis; however, MPs also contribute to tumor progression and resistance immune checkpoint blockade (ICB). Targeting could be an effective strategy enhance ICB efficacy. We report that protein kinase C delta (PKCδ), serine/threonine kinase, is abundantly expressed by human mouse tumors. PKCδ −/− mice displayed reduced compared wild types, with increased response anti–PD-1. Tumors from demonstrated T H 1-skewed including antigen...
Cancers develop resistance to inhibitors of oncogenes mainly due target-centric mechanisms such as mutations and splicing. While or antagonists force targets unnatural conformation contributing protein instability resistance, activating tumor suppressors may maintain the in an agonistic elicit sustainable growth inhibition. Due lack suppressor agonists, this hypothesis underlying are not understood. In estrogen receptor (ER)-positive breast cancer (BC), androgen (AR) is a druggable offering...
Abstract Purpose: The objective of this study is to characterize the role miRNAs in classification head and neck squamous cell carcinoma (HNSCC). Experimental Design: Here, we analyzed 562 HNSCC samples, 88 from a novel cohort 474 Cancer Genome Atlas, using miRNA microarray sequencing, respectively. Using an integrative correlations method followed by expression–based hierarchical clustering, validated clusters across cohorts. Evaluation logistic regression gene ontology approaches revealed...
Obesity is one of the most prevalent chronic diseases and has become a global epidemic. leads to greater risk breast cancer (BC), metastases, recurrence, decreased survival. For sustained weight loss, bariatric surgery effective as long-term solution. Bariatric associated with improved outcomes several cancers including BC, although mechanisms mediating this protection are unknown. We hypothesized that elevated bile acid pools detected after may be factors contribute BC outcomes. Indeed,...
ABSTRACT Breast cancer (BC) is the most common and second cause of death in US women. Our lack understanding how genetic variants affect molecular mechanisms that mediate BC aggression poses a substantial obstacle to advancements diagnosis therapy. To examine on traits, novel murine model was created with robust phenotypic genomic variation. The FVB C3(1)-T-antigen (“C3Tag”) mouse develops spontaneous tumors mammary glands female mice mean latency 4-5 months age. This genetically engineered...
Abstract Background: TP53 is the gene most frequently disrupted by somatic alterations in cancer. Mutations include single nucleotide variants resulting functional alterations, as well premature stop codons, splice variants, and cryptic alterations. dosage heterozygous homozygous deletions, copy-neutral loss of heterozygosity, other structural changes such intragenic deletions fusions. altered epigenetic events viral oncogenes, E6 expressed human papillomavirus. The readout includes...
Abstract Human papilloma virus (HPV) infection causes over 600,000 human cancers yearly and accounts for nearly all cervical cancers, increasing rates of head neck squamous cell carcinomas (HNSCC), many anogenital - with varying clinical outcomes due to a lack personalized care. While recent integrative genomic studies have described molecular features individual cancer types, few compared changes between HPV(+) HPV(-) across anatomic sites. Here, we conducted the first pan-cancer analysis...
Abstract Motivation Somatic DNA copy number alterations (CNAs) arise in tumor tissue because of underlying genomic instability. Recurrent CNAs that occur the same region across multiple independent samples are interest to researchers they may contain genes contribute cancer phenotype. However, differences states between cancers also commonly interest, for example when comparing tumors with distinct morphologies anatomic location. Current methodologies limited by their inability perform...
Abstract Checkpoint immunotherapy unleashes T cell antitumor potential which has revolutionized cancer treatment showing unprecedented long-term responses. However, most patients do not respond to often correlates with a dysfunctional or immunosuppressive myeloid compartment. The mononuclear phagocyte system (MPS) is sub-class of cells comprising monocytes, macrophages and dendritic plays crucial role in tissue homeostasis. accumulating evidence suggests that phagocytes contribute all phases...
Abstract Immunotherapy has revolutionized cancer treatment showing unprecedented long-term antitumor responses. However, most patients do not respond to immunotherapy. Increasing preclinical and clinical evidence suggests that high tumor mutational burden does always correlate with immunotherapy efficacy. Interestingly, cancers have been associated viruses imply the pre-existing presentation of viral antigens may confer an increased response rate This important role antigen presentation,...
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