A5101934065- Drug Transport and Resistance Mechanisms
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Molecular Biology Techniques and Applications
- Gut microbiota and health
- Estrogen and related hormone effects
- MicroRNA in disease regulation
- Gene expression and cancer classification
- Phagocytosis and Immune Regulation
- Esophageal Cancer Research and Treatment
- Dietary Effects on Health
- Neuroendocrine Tumor Research Advances
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Cancer, Stress, Anesthesia, and Immune Response
University of Tennessee Health Science Center
2023-2025
Ducks Unlimited
2024
Bariatric surgery is associated with improved outcomes for several cancers, including breast cancer (BC), although the mechanisms mediating this protection are unknown. We hypothesized that elevated bile acid pools detected after bariatric may be factors contribute to BC outcomes. Patients greater expression of receptor FXR displayed survival in specific aggressive subtypes. a nuclear hormone activated by primary acids. Therefore, we posited activating using an established FDA-approved...
Abstract Medical therapeutics for weight loss are changing the landscape of obesity but impacts on obesity-associated cancer remain unclear. We report that in pre-clinical models with significant retatrutide (RETA, LY3437943)-induced loss, pancreatic engraftment was reduced, tumor onset delayed, and progression attenuated resulting a 14-fold reduction volume compared to only 4-fold single agonist semaglutide-treated mice. Despite re-gain after RETA withdrawal, anti-tumor benefits persisted....
Mononuclear phagocytes (MPs) play a crucial role in tissue homeostasis; however, MPs also contribute to tumor progression and resistance immune checkpoint blockade (ICB). Targeting could be an effective strategy enhance ICB efficacy. We report that protein kinase C delta (PKCδ), serine/threonine kinase, is abundantly expressed by human mouse tumors. PKCδ −/− mice displayed reduced compared wild types, with increased response anti–PD-1. Tumors from demonstrated T H 1-skewed including antigen...
Obesity is one of the most prevalent chronic diseases and has become a global epidemic. leads to greater risk breast cancer (BC), metastases, recurrence, decreased survival. For sustained weight loss, bariatric surgery effective as long-term solution. Bariatric associated with improved outcomes several cancers including BC, although mechanisms mediating this protection are unknown. We hypothesized that elevated bile acid pools detected after may be factors contribute BC outcomes. Indeed,...
ABSTRACT Breast cancer (BC) is the most common and second cause of death in US women. Our lack understanding how genetic variants affect molecular mechanisms that mediate BC aggression poses a substantial obstacle to advancements diagnosis therapy. To examine on traits, novel murine model was created with robust phenotypic genomic variation. The FVB C3(1)-T-antigen (“C3Tag”) mouse develops spontaneous tumors mammary glands female mice mean latency 4-5 months age. This genetically engineered...
<h3>Background</h3> History of bariatric surgery is associated with reduced risk and improved outcomes subsequent breast cancer, including lower stage at diagnosis, fewer metastases, higher immunotherapy response rates in patients.<sup>1 2</sup> One potential mechanism surgery-induced protection modulation the gut microbiome circulating microbially derived metabolites. Importantly, reduces obesity-associated dysbiosis microbiota both patients preclinical models,<sup>3–5</sup> which we...