A5043286744- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Treatment of Major Depression
- Airway Management and Intubation Techniques
- Transcranial Magnetic Stimulation Studies
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Neurological Disease Mechanisms and Treatments
- Obsessive-Compulsive Spectrum Disorders
- Bipolar Disorder and Treatment
- Simulation-Based Education in Healthcare
- Schizophrenia research and treatment
- Electroconvulsive Therapy Studies
- Functional Brain Connectivity Studies
- Epilepsy research and treatment
- Health, Environment, Cognitive Aging
- Advanced Neuroimaging Techniques and Applications
- Bioinformatics and Genomic Networks
- Tryptophan and brain disorders
- Diet and metabolism studies
- Trauma Management and Diagnosis
- Pain Management and Treatment
- Body Image and Dysmorphia Studies
University of South Florida
2023-2024
USF Health Byrd Alzheimer's Institute
2023-2024
Augusta University
2016-2021
East Central University
2019-2021
Bridge University
2019
The University of Texas Health Science Center at San Antonio
2014-2017
Department of Behavioral Health
2017
UCLouvain Saint-Louis Brussels
2012
Brigham and Women's Hospital
2010
Agency for Healthcare Research and Quality
2010
Few data exist on pediatric cardiopulmonary resuscitation (CPR) quality. This study is the first to evaluate actual in-hospital CPR. We hypothesized that with bedside CPR training and corrective feedback, quality can approach American Heart Association (AHA) targets.Using recording/feedback defibrillators, of was assessed for patients >or=8 years age who suffered a cardiac arrest in PICU or emergency department (ED). Before during study, program initiated.Between October 2006 February 2008,...
Tracheal intubation in the pediatric intensive care unit is often performed emergency situations with high risks. Simulation has been recognized as an effective methodology to train both technical and teamwork skills. Our objectives were develop a feasible tool evaluate team performance during tracheal apply clinical setting determine whether multidisciplinary teams higher number of simulation-trained providers exhibit more proficient performance.Prospective, observational pilot study.Single...
Interleukin (IL-15), a pro-inflammatory cytokine has been studied as possible marker of Alzheimer's disease (AD); however its exact role in neuro-inflammation or the pathogenesis AD is not well understood yet. A Multiple Indicators Causes (MIMIC) approach was used to examine relationship between serum IL-15 levels and characterized cohort, Texas Research Care Consortium (TARCC). Instead categorical diagnoses, we two latent construct d (for dementia) g' cognitive impairments contributing...
Vitamin D binding protein (VDBP), a multifunctional protein, has been found to be elevated in the cerebrospinal fluid (CSF) of neurodegenerative disorder cases, implicating it pathogenesis Alzheimer's disease (AD). However, contribution VDBP AD not fully explored. We used Multiple Indicators Causes (MIMIC) approach examine relationship between serum levels and cognitive performance well characterized cohort, Texas Research Care Consortium (TARCC). Instead categorical diagnoses, we latent...
The latent variable "δ" (for "dementia") uniquely explains dementia severity. Depressive symptoms are independent predictors of δ. We explored 115 serum proteins as potential causal mediators the effect depressive on δ in a large, ethnically diverse, longitudinal cohort. All models were adjusted for age, apolipoprotein E, education, ethnicity, gender, hemoglobin A1c, and homocysteine, replicated randomly selected 50% subsets. Alpha1-antitrypsin (A1AT), FAS, Heparin-binding EGF-like Growth...
Abstract Objective Clozapine use is associated with myocarditis. In this study, we investigated what clinical signs and symptoms, and/or laboratory test(s), alert clinicians to presumptive myocarditis (PrMy) most accurately at the earliest time point. We also incidence of PrMy during initial exposure clozapine versus in patients restarted on after extended interruption prior prolonged treatment. Methods 100 admitted state psychiatric hospital started were recruited into study. 76 treated for...
The latent variable "δ" (for "dementia") appears to be uniquely responsible for the dementing aspects of cognitive impairment. Age, depression, gender and apolipoprotein E (APOE) e4 allele are independently associated with δ. In this analysis, we explore serum proteins as potential mediators APOE's specific association δ in a large, ethnically diverse longitudinal cohort, Texas Alzheimer's Research Care Consortium (TARCC). APOE was only C-Reactive Protein (CRP), Adiponectin (APN)...
To develop a scoring system that can assess the multidisciplinary management of respiratory failure in pediatric ICU.In single tertiary ICU we conducted simulation-based evaluation patient care area auxiliary to ICU. The subjects were and emergency medicine residents, nurses, therapists who work A focus group with experienced providers airway safety specialists was formed. task-based instrument developed evaluate primary provider's performance through Healthcare Failure Mode Effect Analysis....
The latent variable "δ" (for "dementia") appears to be uniquely responsible for the dementing aspects of cognitive impairment.Age, depressive symptoms, gender and apolipoprotein E (APOE) ε4 allele are independently associated with δ.In this analysis, we explore serum proteins as potential mediators age's specific association δ in a large, ethnically diverse longitudinal cohort, Texas Alzheimer's Research Care Consortium (TARCC).22 were recognized partial δ.These include Insulin-like Growth...
About 30 to 46% of patients with major depressive disorder (MDD) fail fully respond initial antidepressants. Treatment-resistant depression (TRD) is a severely disabling no proven treatment options; novel methods like rTMS can be used as augmentation ongoing pharmacotherapy or solitary method treatment. To evaluate the utility repetitive transcranial magnetic stimulation an augmenting in TRD. In open-label study, 21 DSM-IV MDD without psychotic features who had failed adequate trial at least...
Informed consent forms are required in all clinical trials which approved by an independent Ethics Committee before practical use the trials. However, how much average subject actually understands of information contained these informed is uncertain.In a cross sectional study, translated used psychiatric were assessed with respect to their ease readability.We analyzed 30 from English Hindi multinational and multicentre sponsored different sponsors. We examined for readability scores factors...
Background: About 30–46% of patients with major depressive disorder (MDD) fail to fully respond initial antidepressants. Treatment-resistant depression is a severely disabling no proven treatment options; novel methods, such as repetitive transcranial magnetic stimulation (rTMS) can be used augmentation ongoing pharmacotherapy or solitary method treatment. Aim: To evaluate the utility rTMS an augmenting in treatment-resistant depression. Materials and Methods: In open-label study, 21 DSM-IV...
Dementia severity can be empirically described by the latent dementia phenotype "δ" and its various composite "homologs". We have explored δ's blood-based protein biomarkers in Texas Alzheimer's Research Care Consortium (TARCC) study. However, it would convenient to replicate those associations Disease Neuroimaging Initiative (ADNI). To this end, we recently engineered a δ homolog from observed cognitive performance measures common both projects (i.e., "dT2A").
Background Alzheimer's disease (AD) is a form of dementia, marked by amyloid-β plaques, neurofibrillary tangles, and neuronal loss. The amyloid burden has been associated with cognitive impairment depression, suggesting potential link between these conditions. Objective This study investigates the relationships burden, impairment, depression in preclinical stages AD. Methods Data from Anti-Amyloid Treatment Asymptomatic (A4) study, involving 4486 cognitively unimpaired individuals aged...
Background: The role of nigrostriatal dopaminergic neurons degeneration is well established in the pathophysiology Parkinson’s disease. However, it unclear if and how dopamine pathways affects manifestation neuropsychiatric symptoms (NPS) disease (PD). Dopamine transporter (DAT) imaging, a technique to measure reduction transporters increasingly used as tool diagnosis PD. Methods: In this study, we examine baseline density striatum measured by striatal binding ratio (SBR) associated with...
Zotepine is an antipsychotic used in Japan and Europe for years recently being introduced Indian markets. It claimed to be particularly effective negative symptoms, somnolence weight gain are the most common side effects. Our aim share our clinical experience of use zotepine with respect its tolerability. We reviewed first 10 patients who were prescribed at center.