A5038126217- IL-33, ST2, and ILC Pathways
- Single-cell and spatial transcriptomics
- Inflammatory Bowel Disease
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Microscopic Colitis
- T-cell and B-cell Immunology
- Cytomegalovirus and herpesvirus research
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
Technical University of Denmark
2024
Karolinska Institutet
2021-2022
Karolinska University Hospital
2022
Therapeutic promotion of intestinal regeneration holds great promise, but defining the cellular mechanisms that influence tissue remains an unmet challenge. To gain insight into process mucosal healing, we longitudinally examined immune cell composition during damage and regeneration. B cells were dominant type in healing colon, single-cell RNA sequencing (scRNA-seq) revealed expansion IFN-induced subset experimental predominantly located damaged areas associated with colitis severity....
Engineering of extracellular vesicles (EVs) towards more efficient targeting and uptake to specific cells has large potentials for their application as therapeutics. Carbohydrates play key roles in various biological interactions are essential EV biology. The extent which glycan modification EVs can be achieved through genetic glycoengineering parental not been explored yet. Here we introduce targeted cell-based via enzymes the glycosylation machinery. In a "simple cell" strategy, modified...
Little is known about the pro-resolution role of immune cells recruited to damaged tissue. Using an experimental model intestinal epithelial damage and repair, we identified B as dominant cell type in healing colon. Single-cell RNA-sequencing (scRNAseq) revealed expansion IFN-induced subset during mucosal which was associated with colitis severity. In line this, depletion resulted accelerated recovery upon injury, enhanced expression tissue remodeling genes. scRNA-seq from stromal...