A5057712123- Circadian rhythm and melatonin
- Single-cell and spatial transcriptomics
- Genetics, Aging, and Longevity in Model Organisms
- Protist diversity and phylogeny
- Spaceflight effects on biology
- Cerebrospinal fluid and hydrocephalus
- RNA modifications and cancer
- Cell Image Analysis Techniques
- Genetic and Kidney Cyst Diseases
- Gene Regulatory Network Analysis
- Extracellular vesicles in disease
- Plant Gene Expression Analysis
- Plant and animal studies
- IL-33, ST2, and ILC Pathways
- Inflammatory Bowel Disease
- Plant Molecular Biology Research
- Cancer-related molecular mechanisms research
- Bioinformatics and Genomic Networks
- Plant biochemistry and biosynthesis
- Light effects on plants
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Microscopic Colitis
- Neuroinflammation and Neurodegeneration Mechanisms
- Horticultural and Viticultural Research
University of Chinese Academy of Sciences
2022-2024
Shanghai Institute of Nutrition and Health
2019-2024
Xinxiang Medical University
2020-2023
Chinese Academy of Sciences
2019
Shanghai Institutes for Biological Sciences
2019
The great variety of brain cell types is a fundamental element for neuronal circuits. One major goal modern neuroscience to decipher the various cellular composition and characterize their properties. Due high heterogeneity cells, until recently, it was not possible group at resolution. Thanks single-cell transcriptome technology, dedicated database across species has been established. Here, we developed scBrainMap, associated genetic markers several species. current scBrainMap contains 4881...
Post-translational histone modifications play important roles in regulating chromatin structure and transcriptional regulation. Histone 3 lysine 4 trimethylation (H3K4me3) is a prominent modification mainly associated with gene activation. Here we showed that demethylase, JMJ15, belonging to KDM5/JARID group, involved salt stress response Arabidopsis thaliana. Jmj15 loss-of-function mutants displayed increased sensitivity stress. Moreover, knockout of JMJ15 impaired the responsive expression...
Abstract Background Circadian rhythm, regulated by both internal and external environment of the body, is a multi-scale biological oscillator great complexity. On molecular level, thousands genes exhibit rhythmic transcription, which organ- species-specific, but it remains mystery whether some common factors could potentially explain their rhythmicity in different organs. In this study we address question analyzing transcriptome data 12 mouse organs to determine such major impacting factors....
Single-cell studies in neuroscience require precise cell type classification and consistent nomenclature that allows for meaningful comparisons across diverse datasets. Current approaches often lack the ability to identify fine-grained types establish standardized annotations at cluster level, hindering comprehensive understanding of brain's cellular composition. To facilitate data integration multiple models datasets, we designed BrainCellR. This pipeline provides researchers with a...
Abstract Intraflagellar transport ( IFT ) represents a bidirectional dynamic process that carries cargo essential for cilia building and the maintenance of ciliary function, which is important locomotion single cells, intracellular intercellular signalling transduction. Accumulated evidence has revealed defects in cause several clinical disorders. Here, we determined role 80, an ‐B protein mutated Jeune asphyxiating thoracic dystrophy. Using RNA i method ciliate Paramecium as model, found...
Abstract Single-cell studies in neuroscience require precise cell type classification and consistent nomenclature that allows for meaningful comparisons across diverse datasets. Current approaches often lack the ability to identify fine-grained types establish standardized annotations at cluster level, hindering comprehensive understanding of brain’s cellular composition. To facilitate data integration multiple models datasets, we designed BrainCellR. This package provides researchers with a...
Abstract Although the individual transcriptional regulators of core circadian clock are distinct amongst different organisms, autoregulatory feedback loops they form conserved. This unified design principle explains how daily physiological activities oscillate across species. However, whether analogous principles govern gene expression output clocks is unknown. Herein, we performed a comparative analysis rhythmic in eight diverse species and captured four common distribution patterns cycling...
Abstract Background Lonicera Japonica Thunb. is a perennial, semi-evergreen and twining vine in the family of Caprifoliaceae, which widely cultivated Asia. Thus far, L. japonica often used to treat some human diseases including COVID-19, H1N1 influenza hand-foot-and-mouth diseases, however, regulatory mechanism intrinsic physiological processes during different floral developmental stages remain largely unknown. Results The complete transcriptome was de novo-assembled annotated, generating...