A5016759473- Epigenetics and DNA Methylation
- Single-cell and spatial transcriptomics
- Genomics and Chromatin Dynamics
- Immune Cell Function and Interaction
- Circadian rhythm and melatonin
- Cancer Genomics and Diagnostics
- Protein Hydrolysis and Bioactive Peptides
- Gene expression and cancer classification
- Cell Image Analysis Techniques
- Immune responses and vaccinations
- Genetics, Aging, and Longevity in Model Organisms
- Computational Drug Discovery Methods
- Gene Regulatory Network Analysis
- Immune cells in cancer
- RNA Research and Splicing
Shanghai Institute of Nutrition and Health
2023-2024
University of Chinese Academy of Sciences
2023-2024
Chinese Academy of Sciences
2023-2024
China Pharmaceutical University
2020
Abstract DNA methylation clocks can accurately estimate chronological age and, to some extent, also biological age, yet the process by which age-associated (DNAm) changes are acquired appears be quasi-stochastic, raising a fundamental question: how much of an epigenetic clock’s predictive accuracy could explained stochastic DNAm change? Here, using data from sorted immune cells, we build realistic simulation models, subsequently demonstrating in over 22,770 and whole-blood samples 25...
Abstract The cumulative number of stem cell divisions in a tissue, known as mitotic age, is thought to be major determinant cancer-risk. Somatic mutational and DNA methylation (DNAm) clocks are promising tools molecularly track yet their relationship underexplored potential for cancer risk prediction normal tissues remains demonstrated. Here we build validate an improved pan-tissue DNAm counter total age called stemTOC. We demonstrate that stemTOC’s proxy increases with the tumor...
The great variety of brain cell types is a fundamental element for neuronal circuits. One major goal modern neuroscience to decipher the various cellular composition and characterize their properties. Due high heterogeneity cells, until recently, it was not possible group at resolution. Thanks single-cell transcriptome technology, dedicated database across species has been established. Here, we developed scBrainMap, associated genetic markers several species. current scBrainMap contains 4881...
The ability to accurately quantify biological age could help monitor and control healthy aging. Epigenetic clocks have emerged as promising tools for estimating age, yet they been developed from heterogeneous bulk tissues, are thus composites of two aging processes, one reflecting the change cell-type composition with another individual cell-types. There is a need dissect these components epigenetic clocks, develop that can yield estimates at resolution. Here we demonstrate in blood brain,...
Brain-derived transcriptomes are known to correlate with resting-state brain activity in humans. Whether this association holds nonhuman primates remains uncertain. Here, we search for such molecular correlates by integrating 757 derived from 100 macaque cortical regions separate conspecifics. We observe that 150 noncoding genes explain variations at a comparable level protein-coding genes. In-depth analysis of these reveals they connected the function nonneuronal cells as oligodendrocytes....
The ability to accurately quantify biological age could help monitor and control healthy aging. Epigenetic clocks have emerged as promising tools for estimating age, yet they been developed from heterogeneous bulk tissues, are thus composites of two aging processes, one reflecting the change cell-type composition with another individual cell-types. There is a need dissect these components epigenetic clocks, develop that can yield estimates at resolution. Here we demonstrate in blood brain,...
Abstract Background: Changes in cell-type composition of complex tissues are associated with a wide range diseases, environmental risk factors and may be causally implicated disease development progression. However, these shifts fractions often low magnitude, or involve similar cell-subtypes, making their reliable identification challenging. DNA methylation profiling tissue like blood is promising approach to discover abundance, yet studies have only been performed at relatively cellular...
Abstract The cumulative number of stem cell divisions in a tissue, known as mitotic age, is thought to be major determinant cancer-risk. Somatic mutational and DNA methylation (DNAm) clocks are promising tools molecularly track yet their relationship underexplored potential for cancer risk prediction normal tissues remains demonstrated. Here we build validate an improved pan-tissue DNAm counter total age called stemTOC. We demonstrate that stemTOC’s proxy increases with the tumor...