A5087416952- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Tracheal and airway disorders
- Sarcoidosis and Beryllium Toxicity Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Allergic Rhinitis and Sensitization
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inhalation and Respiratory Drug Delivery
- Airway Management and Intubation Techniques
- Neonatal Respiratory Health Research
- Thyroid Disorders and Treatments
- Thermal Regulation in Medicine
- Cardiac Arrest and Resuscitation
- Neuroscience of respiration and sleep
- Restraint-Related Deaths
- Congenital Diaphragmatic Hernia Studies
- Lung Cancer Diagnosis and Treatment
- Nosocomial Infections in ICU
- Pediatric health and respiratory diseases
- Peptidase Inhibition and Analysis
- Dermatology and Skin Diseases
- Eosinophilic Esophagitis
- Long-Term Effects of COVID-19
- Ultrasound in Clinical Applications
Ospedale Santa Maria
2008-2025
Azienda Ospedaliera di Perugia
2009-2023
University of Perugia
2016-2023
Ospedale San Paolo
2022
University of Milan
1986-2022
Misericordia University
2016
University of Pavia
2016
University of Basel
1988
University College Hospital at Westmoreland Street
1988
University College London
1988
Ten patients with full-blown ARDS, on mechanical ventilation PEEP underwent lung CT. Seven normal subjects were also studied. Three tomographic levels (apex, hilum, and base) selected. The most consistent morphologic finding in ARDS was he presence of densities the dependent regions lung. Assuming that three a representative sample whole lung, weight computed from mean CI number gas volume. Analysis frequency distribution revealed definite patterns distribution; type I, bimodal, one mode CT...
Platelets are essential for pulmonary leukocyte recruitment, airway hyperresponsiveness, and bronchial remodeling in animals with allergic inflammation can be found bronchoalveolar lavage of sensitized animals. No studies, however, have explored the direct migration platelets to lungs.To assess whether migrate into lung parenchyma response inhaled allergen ovalbumin-sensitized mice; role FcepsilonRI receptor this phenomenon; evaluate from patients asthma, or mice, undergo chemotaxis vitro...
Background Dysregulated systemic inflammation is the primary driver of mortality in severe coronavirus disease 2019 (COVID-19) pneumonia. Current guidelines favour a 7–10-day course any glucocorticoid equivalent to dexamethasone 6 mg daily. A comparative randomised controlled trial (RCT) with higher dose and longer duration intervention was lacking. Methods We conducted multicentre, open-label RCT investigate methylprednisolone 80 as continuous daily infusion for 8 days followed by slow...
Various low triiodothyronine (T3) states have been described in severe nonthyroidal diseases and associated with a poor prognosis cardiovascular disease patients. We assessed thyroid function patients respiratory failure from pulmonary disorders, needing invasive or noninvasive mechanical ventilation, order to evaluate the prognostic value of illness syndrome.We studied 32 consecutive acute acute-on-chronic failure. Measured variables upon admission included APACHE II score, ratio partial...
Objective It remains unclear whether baseline FENO levels can predict response to anti-IL5/5R biologic treatment in patients with severe asthma.
Sarcoidosis features non-necrotizing granulomas consisting mainly of activated CD4-lymphocytes. T-cell activation is regulated by immune checkpoint (IC) molecules. The present study aimed to compare IC expression on CD4, CD8 and NK cells from peripheral, alveolar lung‐draining lymph node (LLN) samples sarcoidosis patients. Flow-cytometry analysis was performed detect molecules a regression decision tree model constructed investigate potential binary classifiers for diagnosis as well the...
(1) Background: Sarcoidosis is a chronic multisystem disorder of unknown aetiology, driven by T-cell mechanism allowing attachment and transmigration through the endothelium, endorsed expression an integrin alpha-E beta-7 (CD103). This study aimed to analyse different distribution compartmentalisation CD103 on T cell subsets in BAL, peripheral blood mononuclear cells (PBMC) lymph nodes (LLN) from sarcoidosis patients. (2) Patients: We consecutively prospectively enrolled 14 collected PBMC,...
Background Spore Trap is an environmental detection technology, already used in the field of allergology to monitor presence and composition potentially inspirable airborne micronic bioparticulate. This device suitable for monitoring Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) hospital, as well other high-risk closed environments. The aim present study investigate accuracy system detecting SARS-CoV-2 indoor bioaerosol hospital rooms. Methods was placed rooms hosting patients...
Sarcoidosis is a granulomatous diseases affecting the lungs. Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) histologically B-mediated disorder characterized by activated T cells. The expression of immune checkpoint (IC) molecules (PD1, CTLA4, TIGIT) on T- and NK-cells negatively regulate T-cell function. present study aimed to explore peripheral distribution IC better elucidate their tolerance failure, which might reflect development diseases. Patients referred...
<b><i>Background:</i></b> It is not clear whether mepolizumab differently effective in allergic and nonallergic severe eosinophilic asthmatics (SEA) real life. <b><i>Objective:</i></b> We tested effectiveness allergic/nonallergic SEA A strict criterion to identify the 2 phenotypes was used. <b><i>Method:</i></b> retrospectively considered 134 consecutive patients divided into allergic, with a positivity at least 1...
Sarcoidosis is a systemic granulomatous disease mainly affecting the lungs and hilomediastinal lymph nodes. It characterized by non-caseating epithelioid cell granulomas in nodes lungs. Our study aimed to evaluate compare T, B NK subsets alveolar compartment, bloodstream simultaneously same patients elucidate immune responses associated with development progression of sarcoidosis. A secondary aim was distribution CD45RA-expressing cells different anatomical compartments. Patients suspected...
The aims of this study were to (1) quantify the particle size characteristics several antibiotics considered suitable for aerosol therapy after aerosolization with PARI IS/2 nebulizer (Pari GmbH, Sarnberg, Germany) and (2) determine degree which in vitro antimicrobial activity these is maintained nebulization. aerosolized drugs tobramycin sulfate, streptomycin, imipenem, saline solution as control. Mean mass aerodynamic diameter nebulized was 3.25 microns tobramycin, 2.26 2.38 streptomycin....