A5010910319- Liver physiology and pathology
- Liver Diseases and Immunity
- Liver Disease Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatitis Pathology and Treatment
- Nuclear Receptors and Signaling
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Apelin-related biomedical research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Liver Disease and Transplantation
- MicroRNA in disease regulation
- Circadian rhythm and melatonin
- Fibroblast Growth Factor Research
- RNA modifications and cancer
- Digestive system and related health
- Cancer-related molecular mechanisms research
- Ovarian cancer diagnosis and treatment
- Genetic and Kidney Cyst Diseases
- Iron Metabolism and Disorders
- Erythropoietin and Anemia Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- DNA Repair Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Clinical Nutrition and Gastroenterology
- Diagnosis and treatment of tuberculosis
Texas A&M University
2018-2022
Texas A&M Health Science Center
2017-2022
Indiana University – Purdue University Indianapolis
2022
Indiana University School of Medicine
2022
University of Rome Tor Vergata
2022
Sapienza University of Rome
2022
Bryan College
2019-2022
Richard L. Roudebush VA Medical Center
2022
Temple College
2016-2018
Central Texas Veterans Health Care System
2016-2018
Background and Aims Apelin (APLN) is the endogenous ligand of its G protein–coupled receptor, apelin receptor (APJ). APLN serum levels are increased in human liver diseases. We evaluated whether APLN–APJ axis regulates ductular reaction fibrosis during cholestasis. Approach Results measured expression APJ primary sclerosing cholangitis (PSC) samples. Following bile duct ligation (BDL) or sham surgery, male wild‐type (WT) mice were treated with ML221 (APJ antagonist) saline for 1 week. WT −/−...
Background and Aims Serotonin (5HT) is a neuroendocrine hormone synthetized in the central nervous system (CNS) as well enterochromaffin cells of gastrointestinal tract. Tryptophan hydroxylase (TPH1) monoamine oxidase (MAO‐A) are key enzymes for synthesis catabolism 5HT, respectively. Previous studies demonstrated that 5‐hydroxytryptamine receptor (5HTR)1A/1B agonists inhibit biliary hyperplasia bile‐duct ligated (BDL) rats, whereas 5HTR2B antagonists attenuate liver fibrosis (LF) mice. Our...
Cholangiocytes are the target cells of cholangiopathies including primary sclerosing cholangitis (PSC). Vimentin is an intermediate filament protein that has been found in various types mesenchymal cells. The aim this study to evaluate role vimentin progression biliary damage/liver fibrosis and whether there a phenotype cholangiocytes Mdr2-/- model PSC.In vivo studies were performed 12 wk. male mice with or without Vivo-Morpholino treatment their corresponding control groups. Liver specimens...
Cholangiocarcinoma (CCA), or cancer of bile duct epithelial cells, is a very aggressive malignancy characterized by early lymphangiogenesis in the tumor microenvironment (TME) and lymph node (LN) metastasis which correlate with adverse patient outcome. However, specific roles lymphatic endothelial cells (LECs) that promote LN remains unexplored. Here we aimed to identify dynamic molecular crosstalk between LECs CCA activate tumor-promoting pathways enhances lymphangiogenic mechanisms. Our...
We studied the effect of age on relationship between haemoglobin and serum erythropoietin (EPO) levels in anaemic patients. 568 patients over 70 years were compared with 137 under a reference group 144 all ages proven iron deficiency. EPO was measured using radioimmunoassay. found that elderly normocytic anaemia (N = 375) had statistically lower response than younger 61) (p < 0.05) or iron-deficiency 0.05). There no difference sexes. Elderly microcytic macrocytic normal as to "gold standard"...
Melatonin, a neuroendocrine hormone synthesized by the pineal gland and cholangiocytes, decreases biliary hyperplasia liver fibrosis during cholestasis-induced injury via melatonin-dependent autocrine signaling through increased arylalkylamine N-acetyltransferase (AANAT) expression melatonin secretion, downregulation of miR-200b specific circadian clock genes. Melatonin synthesis is decreased pinealectomy (PINX) or chronic exposure to light. We evaluated effect PINX prolonged light on...
α7-nAChR is a nicotinic acetylcholine receptor [specifically expressed on hepatic stellate cells (HSCs), Kupffer cells, and cholangiocytes] that regulates inflammation apoptosis in the liver. Thus, targeting may be therapeutic biliary diseases. Bile duct ligation (BDL) was performed wild-type (WT) −/− mice. We first evaluated expression of by immunohistochemistry (IHC) liver sections. IHC also to assess intrahepatic bile mass (IBDM), Sirius Red staining quantify amount collagen deposition....
Fibroblast growth factor 1 (FGF1) belongs to a family of factors involved in cellular and division. MicroRNA 16 (miR‐16) is regulator gene expression, which dysregulated during liver injury insult. However, the role FGF1 progression biliary proliferation, senescence, fibrosis, inflammation, angiogenesis, its potential interaction with miR‐16, are unknown. In vivo studies were performed male bile duct–ligated (BDL, 12‐week‐old) mice, multidrug resistance 2 knockout (Mdr2 −/−) mice...
A number of workers have examined protein C in relation to other vitamin K dependent factors during warfarin therapy and successfully identified deficient patients by ratio calculation. However, S deficiency has not been addressed this manner. This study compares functional antigenic determination with procoagulant similar half life (Factors VII II) an attempt identify whilst on oral anticoagulant therapy. Procoagulant were compared linear regression a population normal blood donors...
Cholestatic liver disease encompasses a detrimental group of diseases that are non-discriminatory in nature. These occur over every age range from infancy (biliary atresia) to geriatrics (hepatitis). They also cover both genders the form primary sclerosing cholangitis men and biliary women. Oftentimes, owing progression extensive scarring, treatment last resort becomes transplant. In this review, we will briefly discuss explore new avenues understanding cholestatic possible therapeutic...
Nicotine, the major psychoactive component of cigarette smoke, can stimulate proliferation non‐neuronal cell types and promotes growth solid tumors. Nicotine exerts its functions through nicotinic acetylcholine receptors (nAChRs) has been shown to a number in an α7‐nAChR‐dependent mechanism due activation MAPK signaling pathways. The AIM our study was evaluate effects nicotine on cholangiocarcinoma proliferation. METHODS lines Mz‐ChA‐1, CCLP HuCCT‐1 normal human cholangiocyte line HIBEpiC...
e21012 Background: NSCLC is the most common cause of cancer-related death. Platinum-based chemotherapy mainstay treatment, but a variety mechanisms lead to platinum-resistance. ATF3 transcription factor, activated in response stress signals including DNA damage and hypoxia, shown be involved platinum-induced cytotoxicity. We hypothesized that biomarker mediator platinum-sensitivity NSCLC. Methods: Platinum-resistant (R) cell lines were created by cisplatin selection sensitive (S) lines....
5018 Background: There are no validated molecular biomarkers in EOC which correlate with prognosis or chemosensitivity. Breast cancer 1 (BRCA1) protein inactivation sporadic is common and reduced BRCA1 expression has been linked platinum sensitivity. However, not clinically as a prognostic predictive marker EOC. Methods: The NCIC CTG-led Gynecologic Cancer Intergroup phase III trial, OV.16, compared topotecan/cisplatin followed by carboplatin/paclitaxel to standard advanced patients. With...