The seed oil of Carapa guianensis (Aublet), a tree from the Meliaceae family commonly known as andiroba, is widely used in Brazilian traditional medicine because its multiple curative properties against fever and rheumatism an anti-inflammatory agent, antibacterial insect repellant. Since there no consensus on best way to obtain C. due ethnomedicinal properties, aim present research was evaluate chemical composition, free-radical scavenging activity, mutagenic genotoxicity three oils...

Several epidemiological studies have associated PM2.5 (particulate matter, aerodynamic diameter 2.5 µm) exposure with an increase in morbidity and mortality attributed to cardiopulmonary diseases. Based upon these observations the growing effort replace use of animals research, vitro A549 cells cultured three dimensions (3D), alternative method animals, as well monolayers were investigated examine whether organic extract induced equivalent cytotoxic changes compared vivo. was collected on...

Antarctica moss Sanionia uncinata (Hedw.) Loeske is exposed in situ to damaging levels of ultraviolet (UV) radiation. This has the ability respond UV radiation exposure producing secondary metabolites such as flavonoids, and been recommended a potential source photoprotective compounds antioxidants. The aim present paper was investigate free-radical scavenging activity mutagenic photomutagenic properties methanolic (ME), hydroethanolic (HE) ethanolic (EE) extracts S. uncinata. phenolic...

Resistance to glyphosate herbicide has initiated usage of combined application herbicides as a weed control measure. Imazethapyr-based associated with seem be an alternative suppress resistance. The aim this study was examine the adverse effects Glyphosate Atanor 48® (ATN) and Imazethapyr Plus Nortox® (IMZT) formulations in both single forms mixtures using HepG2 cells zebrafish early-life stages models. Data demonstrated cytotoxicity due exposure ATN, IMZT for models, follows: (1) ATN (0.5...

Background: The Antarctic moss Sanionia uncinata (Hedw.) Loeske has shown high ultraviolet (UV)-absorbers content after exposition to levels of UV-B radiation and can be an important source antioxidants. Objective: aim was investigate photoprotection mutagenicity by the aqueous extract (AE) hydroethanolic (HE) from S. uncinata. Materials Methods: Photoprotective activities were determined through survival curves Escherichia coli strains, UV irradiation in solution thymine vitro sun...

Soursop (Annona muricata) is a tropical tree whose decoction derived from bark, root, seed, or leaf has been used for medicinal uses. In addition, the fruit itself considered food, and juice utilized to treat heart liver diseases. The aim of this study was determine phenolic content. water-soluble fraction soursop pulp (WSSP) examined following properties: antioxidant, mutagenic, antimutagenicity. UV-visible spectrophotometry determined total content by Folin-Ciocalteu method be 11.22 ± 0.6...

Phenolic phytometabolites are promising bioactive compounds for management of genomic instability related diseases. Formononetin (FMN) and arbutin (ARB) found in several plant sources. Our goal was to investigate the safety efficacy FMN ARB using

Several bioactive compounds, such as polyphenols, demonstrate low toxicity and prominent effects on cancer cells with antioxidant, anti-inflammatory, antitumor activities. Such compounds can be found in Amazon mosses Leucobryum martianum (Hornsch.) Hampe ex Müll. Hal. laevifolium (Broth). Antimutagenic assay Salmonella enterica serovar Typhimurium cytotoxicity different eukaryotic cell lines were carried out to screen aqueous, hydroalcoholic, ethanolic extracts of those for anticancer...

When mosses are exposed to increased quantities of ultraviolet (UV) radiation, they produce more secondary metabolites. Antarctica moss Sanionia uncinata (Hedw.) Loeske has presented high carotenoid contents in response an increase UVB radiation. This been recommended as a potential source antioxidants. In the present work, protective and enhancing effects aqueous (AE) hydroalcoholic (HE) extracts S. on cleavage supercoiled DNA were evaluated through topological modifications, quantified by...

The BTEX group (benzene, toluene, ethyl benzene and xylene) are known for their potential toxic, mutagenic carcinogenic effects, especially in an indoor occupational environment, where these substances dissipate with greater difficulty.Thus, the present work evaluated concentrations, mutagenicity cytotoxicity of air workshops involving painting varnishing.Samples were collected using pumps from outside open environment inside each three workshops.The chemical analyses carried out gas...

Abstract Background Ultraviolet (UV) radiation is the main exogenous inductor of skin damage and so photoprotection important to control disorders. The Antarctic moss Sanionia uncinata an source antioxidants photoprotective activity its organic extracts has been investigated. This study aimed evaluate potential photoprotection, cytotoxicity embryotoxicity residual aqueous fraction (AF) from S. . Methods UV-visible spectrum SPF (sun protection factor) were determined by spectrophotometry....

The consumption of dietary supplements to enhance physical performance has increased significantly in the last century, especially thermogenic pre-workout supplements. Nevertheless, this industry faced criticism for inadequate safety measures surveillance regulatory issues regarding their products. aims our study were investigate two with respect (1) mutagenicity utilizing Salmonella/microsome assay; (2) genotoxicity employing cytokinesis-block micronucleus (CBMN) assay protocols; and (3)...

The BTEX group (benzene, toluene, ethyl benzene and xylene) is part of the list volatile organic compounds which cause damage to a worker's health, especially in an indoor occupational environment, where these substances dissipate with greater difficulty.Thus, present work evaluated concentrations, mutagenicity cytotoxicity air workshops involving painting varnishing.The chemical analyses were carried out using HPLC coupled mass spectrometry.The mutagenic potentials determined...

LLL-3, an anthracene derived compound, has been shown to be a promising therapeutic agent for the treatment of some kinds cancer such as chronic myeloid leukemia and glioblastoma. However, no data regarding toxic properties this compound have yet described in literature. The present work aimed investigate mutagenic genotoxic activities LLL-3 using TA97, TA98, TA100, TA102 TA104 Salmonella/microsome strains Ames test micronucleus assay with mouse macrophage cell line RAW 264.7. findings...

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The therapeutic options for Chagas disease are limited and its treatment presents a number of drawbacks including toxicity, drug resistance, insufficient effectiveness against the chronic stage disease. Therefore, new therapeutical mandatory. In present work, we evaluated effect phenyl- tert -butylnitrone (PBN) derivate, LQB 123, Trypanosoma cruzi forms. 123 presented trypanocidal bloodstream trypomastigotes (IC 50 =<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mn...

No presente estudo, foram investigados através de uma revisão sistemática, os efeitos da utilização cafeína sobre o indivíduo nas sessões HIIT. A seleção artigos foi realizada bases dados Medline/PubMed, Science Direct, Scholar Google e Scielo, encontraram-se 2301 estudos. Após aplicar critérios inclusão exclusão considerados elegíveis apenas cinco para a sistemática. Entre esses estudos, total participantes 80 indivíduos, sendo 24 mulheres 56 homens, com idades entre 18 30 anos. Os...