Exogenous gene delivery to alter the function of heart is a potential novel therapeutic strategy for treatment cardiovascular diseases such as failure (HF). Before therapy approaches cardiac can be realized, efficient and reproducible in vivo techniques must established efficiently transfer transgenes globally myocardium. We have been testing hypothesis that genetic manipulation myocardial β-adrenergic receptor (β-AR) system, which impaired HF, enhance function. delivered adenoviral...

Haemophilus parainfluenzae incorporates glycerol and phosphate into the membrane phospholipids without lag during logarithmic growth. In phosphatidyl (PG), unacylated moieties turn over incorporate radioactivity much more rapidly than does diacylated glycerol. At least half is lost from in about 1 doubling. The total fatty acids slightly faster diacyl ethanolamine (PE), which major lipid of bacterium, at as fast PG. PE did not 4 bacterial doublings. phosphatidic acid turns one-third rate...

Kolobow, T.; Gattinoni, L.; Tomlinson, White, D.; Pierce, J.; lapichino, G. Author Information

Purpose: We evaluate the effect of an exercised prehabilitation programme on tumour response in rectal cancer patients following neoadjuvant chemoradiotherapy (NACRT). Patients and Methods: Rectal with (MRI-defined) threatened resection margins who completed standardized NACRT were prospectively studied a post hoc, explorative analysis two previously reported clinical trials. MRI was performed at Weeks 9 14 post-NACRT, surgery Week 15. undertook 6-week preoperative exercise-training...

Journal Article Pink Globalization: Hello Kitty’s Trek across the Pacific Get access Pacific, by Christine R. Yano. Durham, NC: Duke University Press, 2013, xiv + 322 pp., $24.95 (paperback ISBN 978-0-8223-5363-8) Daniel WHITE Hosei Search for other works this author on: Oxford Academic Google Scholar Social Science Japan Journal, Volume 17, Issue 2, Summer 2014, Pages 264–267, https://doi.org/10.1093/ssjj/jyu013 Published: 26 June 2014

The geologic examination of the Perry district, in southeastern Maine, was undertaken at request Survey Commission State Maine. During 1902-3 session Maine legislature an effort made by petitioners resident Washington County to obtain from appropriation $10,000 for coal exploration. resolve proposed contained a ,proviso necessitating additional contribution $5,000 individuals or corporations interested. $15,000 thus procured be expended drilling most promising localities. failed pass, but...

A glucose containing lipid, phosphatidylglucose (probably 3- sn -phosphatidyl-1′-glucose) and a lipid tentatively identified as phosphatidylethanolamine have been characterized in the lipids of Staphylococcus aureus . These together comprise less than 2% total phospholipids exponentially growing S. accumulate to 14% phospholipid stationary-phase cells. lost no 32 P when cells grown with H 3 PO 4 were transferred nonradioactive medium during exponential growth phase. This was marked contrast...

A highly active phospholipase D that is specific for cardiolipin was detected in the gram-negative bacterium Haemophilus parainfluenzae . Previously reported preparations have come exclusively from higher plants. The bacterial enzyme hydrolyzed to phosphatidyl glycerol and phosphatidic acid. During incubation, acid disappeared. Phosphatidyl ethanolamine, methylated ethanolamines, choline, were not when rapidly hydrolyzed.

Summary An 8‐week survey was conducted to determine whether the introduction of low‐flow anaesthesia (a fresh gas flow 4 litres/minute or less) into routine use would be acceptable members a representative anaesthetic department and if consequent reduction in volatile anaesthetics result financial savings. The hourly consumption agents measured during using either conventional low flows. Anaesthetists' acceptance assessed questionnaire. Data were gathered on 286 patients undergoing...

The anterolateral thigh flap is an increasingly popular reconstructive option despite uncertainty in its perforator anatomy. Perforators are not always present, vary size and intramuscular course, have variable cutaneous courses supply. As such, preoperative imaging has become favored.The current study describes the preliminary use of two new modalities for imaging: computed tomography (CT) Angiography CT-guided stereotaxy. These been utilized patients undergoing ALT reconstruction. Each...

The composition of the membrane-bound electron transport system Haemophilus parainfluenzae underwent modification in response to terminal acceptor growth medium. H. was able grow with O 2 , nitrate, fumarate, pyruvate, and substrate amounts nicotinamide adenine dinucleotide (NAD) as acceptors. When served its concentration lowered below 20 μ m bacteria formed more cytochromes b, c, a 1 o than were present cells grown at 150 200 . Nitrate nitrite reductase activities also appeared during low...

Mitochondria were isolated from the heme-requiring insect trypanosomatid, Crithidia fasciculata , which had respiratory activity, showed a P/O ratio with succinate of 0.5 to 1.0, and contained 40 50% heme c found in intact cells. Cytochromes b, 555 possibly 1 cytochrome oxidase, carbon monoxide-binding pigment, flavoproteins detectable spectra both cells mitochondria. Cytochrome is basic protein that was extracted mitochondria salt solutions. The molar approximately 2:1 This organism could...

<i>Aim:</i> To explore the Ecological Plaque Hypothesis for dental caries. test modification of microbiota plaque microcosm biofilms by sucrose pulsing during growth in two different simulated oral fluids, and with a urea-induced pH elevation. <i>Methods:</i> were cultured an ‘artificial mouth’ without 6-min 5% w/v pulses every 8 h environment continuously supplied saliva-like defined medium mucin (DMM), or basal (BMM, high-peptone-yeast extract fluid analogue), also...

After a transition from high to low oxygen tension, there was twofold 50-fold increase in the content of membrane-bound respiratory pigments Haemophilus parainfluenzae , and were concurrent changes metabolism membrane phospholipids: (i) decrease rate turnover phosphate all phospholipids; (ii) shift simple one-phase, linear incorporation into phospholipids complex biphasic (iii) an total with slight proportion phosphatidylglycerol (PG) phosphatidylethanolamine (PE). Changes rates occurred...

Vladimir Putin’s state-building project, which has included a ‘war on the oligarchs’, reining in of regional power, co-optation or marginalization civil society and political opposition, establishment ‘power vertical’, not been based state strengthening but had much more to do with regime consolidation. It is argued that, Russian case, building capacity may be crucial factor determining medium even long-term survival authoritarian system. Although Russia relatively weak capacity, Putin...

Summary The practice of warming blood for transfusion by immersion in a water bath has been studied. Blood, 3 days after collection, with CPD‐adenine anticoagulant, was warmed at 25°C, 37°C and 45°C up to 2 hours. procedure repeated 4 weeks' storage 4°C. Only trivial biochemical morphological changes resulted from warming. Within these limits, appears be reasonable alternative using blood‐warming coil. Other aspects are discussed.

Compounds known to be inhibitors of mixed-function oxidase systems inhibited the aerobic synthesis hydroxylated carotenoids in Staphylococcus aureus U-71. Growth cells presence 2-diethylaminoethyl-2,2-diphenyl valerate, 2,4-dichloro-6-phenylphenoxyethylamine, 2,4-dichloro-6-phenylphenoxyethyldiethylamine, and piperonyl butoxide reduced levels rubixanthins found stationary-phase by 75 97%. In grown with mevalonate- 2 - 14 C , turnover rate phytoene was phytofluenol increased these inhibitors....

Growth of Hemophilus parainjluenzae requires the formation an electron transport system consisting six cytochrome components (1). As a compensatory mechanism for changing environment, this bacterium can modify oxidase composition and proportions cytochromes during conditions where there is no cell division (2). The intact has remarkable permeability to many substrates that reduce respiratory pigments produce oxygen uptake (3). n-Lactate, L-lactate, succinate, reduced diphosphopyridine...

This paper compares the regimes of Turkey and Russia how state capacity has facilitated authoritarian regime building at expense democratic consolidation. It begins by considering best to conceptualize Putin Erdoğan regimes. Whilst recognizing significant differences between two cases, we argue that concepts electoral authoritarianism neopatrimonialism are particularly helpful in better understanding both systems operate. The then discusses concept capacity, arguing for conceptual clarity a...

We studied alterations in the β-adrenergic receptor (β-AR) system of rabbit hearts during development heart failure (HF) after myocardial infarction (MI) to determine whether molecular β-AR abnormalities associated with human HF exist this animal model. Rabbit was established 3 wk left circumflex coronary artery (LCX) ligation by vivo physiological measurements, and signaling examined tissue cultured ventricular myocytes. found that there a significant global reduction density ∼50% both...