A5087994026- Celiac Disease Research and Management
- Microscopic Colitis
- Acute Lymphoblastic Leukemia research
- Galectins and Cancer Biology
- Childhood Cancer Survivors' Quality of Life
- Chronic Myeloid Leukemia Treatments
- COVID-19 and Mental Health
- Chronic Lymphocytic Leukemia Research
- T-cell and B-cell Immunology
- Infection Control and Ventilation
- COVID-19 epidemiological studies
- Helicobacter pylori-related gastroenterology studies
- SARS-CoV-2 and COVID-19 Research
- Renal and related cancers
- Single-cell and spatial transcriptomics
Norwegian Institute of Public Health
2024
Oslo University Hospital
2020-2022
University of Oslo
2016-2021
University of California, San Francisco
2016-2017
657 Oslo
2016
University of San Francisco
2015
Inactivation of the tumor suppressor gene encoding transcriptional regulator Ikaros (IKZF1) is a hallmark BCR-ABL1+ precursor B cell acute lymphoblastic leukemia (pre-B ALL). However, mechanisms by which functions as in pre-B ALL remain poorly understood. Here, we analyzed mouse model together with new inducible expression wild-type IKZF1 mutant human ALL. We performed integrated genome-wide chromatin and analyses identified target genes ALL, revealing novel conserved pathways associated...
Disease-specific plasma cells (PCs) reactive with transglutaminase 2 (TG2) or deamidated gluten peptides (DGPs) are abundant in celiac disease (CeD) gut lesions. Their contribution toward CeD pathogenesis is unclear. We assessed expression of markers associated PC longevity 15 untreated and 26 treated patients addition to 13 non-CeD controls performed RNA sequencing clonal inference transcriptomic analysis 3,251 single PCs. observed antigen-dependent V-gene selection stereotypic antibodies....
Gut intraepithelial γδ and CD8+ αβ T lymphocytes have been connected to celiac disease (CeD) pathogenesis. Based on the previous observation that activated (CD38+), gut-homing (CD103+) cells increase in blood upon oral gluten challenge, we wanted shed light pathogenic involvement of these by examining clonal relationship between gut during exposure. Of 20 gluten-challenged CeD patients, 8 10 had (CD38+CD103+) cells, respectively, while 16 gluten-specific CD4+ cells. We obtained TCR sequences...
A hallmark of celiac disease (CeD), a chronic condition driven by cereal gluten exposure, is increase gut intraepithelial γδ T cells. This may indicate pathogenic involvement cells and existence disease-specific T-cell receptors (TCRs) recognizing defined antigen(s). We performed high-throughput paired TCR sequencing single untreated CeD patients (n = 8; 1821 cells), treated with gluten-free diet 5; 436 cells) controls 7; 1068 cells). found that patients, both treated, had larger more...
For many people public transport is the only mode of travel, and it can be challenging to keep necessary distances in such a restricted space. The exact role transportation risk SARS-CoV-2 transmission not known.Participants (n = 121,374) were untested adult Norwegian residents recruited through social media who spring 2020 completed baseline questionnaire on demographics use transport. Incident cases 1069) had positive polymerase chain reaction test registered at Messaging System for...
Chronic inflammation of the small intestine in celiac disease is driven by activation CD4+ T cells that recognize gluten peptides presented disease-associated HLA-DQ molecules. We have performed direct cell cloning duodenal biopsies from five untreated and one refractory patients, three non-celiac control subjects order to assess, an unbiased fashion, frequency gluten-reactive disease-affected tissue as well antigen fine specificity responding cells. From active lesions 19 T-cell clones were...
Abstract Heterogeneity in vaccine response, particularly vulnerable populations like the elderly, represents a significant public health challenge. We conducted an in-depth examination of immune cell profiles before and after SARS-CoV-2 vaccination utilizing mass cytometry cohort healthy Norwegian seniors (65–80 years). have demonstrated that higher pre-vaccination frequencies CD27 + IgD - class-switched memory B cells subsets CD24 CD38 transitional were associated with robust response....
ABSTRACT Disease-specific plasma cells (PCs) reactive with transglutaminase 2 (TG2) or deamidated gluten peptides (DGP) are abundant in celiac disease (CeD) gut lesions. Their contribution toward CeD pathogenesis is unclear. We assessed expression of markers associated PC longevity 15 untreated and 26 treated patients addition to 13 non-CeD controls, performed RNA-sequencing clonal inference transcriptomic analysis 3251 single PCs. observed antigen-dependent V-gene selection stereotypic...
Abstract Ikaros is a zinc finger transcription factor required for B-cell development and proper hematopoiesis, an important tumor suppressor in developing lymphocytes. To understand the mechanism of function potentially develop new improved targeted therapies, it to elucidate downstream target genes involved. With this aim, we combine mouse models pre-B ALL vitro culture human patient-derived cells. A model with deletion fourth DNA-binding resulted loss function, limited set deregulated...
Abstract Inactivation of the transcriptional factor Ikaros (IKZF1) correlates with poor prognosis in progenitor B-cell acute lymphoblastic leukemia (pre-B ALL), and is a hallmark BCR-ABL1+ subgroup pre-B ALL. critical regulator hematopoietic development required for development, however mechanisms by which functions as tumor suppressor ALL remain poorly understood. We analyzed recently developed mouse models containing targeted deletions DNA-binding zinc finger domains together new model...
Abstract Background: For many people public transport is the only mode of travel, and it can be challenging to keep necessary distances in such a restricted space. The exact role transportation risk SARS-CoV-2 transmission not known. Methods: Participants (n=121 374) were untested adult Norwegian residents recruited through social media who spring 2020 completed baseline questionnaire on demographics use transport. Incident cases (n=1069) had positive polymerase chain reaction test...