A5100696371- MicroRNA in disease regulation
- Osteoarthritis Treatment and Mechanisms
- Circular RNAs in diseases
- Corrosion Behavior and Inhibition
- Cell Adhesion Molecules Research
- Cancer-related molecular mechanisms research
Xiyuan Hospital
2019-2022
Shandong Agricultural University
2016
Purpose: Accumulating evidence suggests that microRNA-145 (miR-145) plays an important role in osteoarthritis (OA), which is a chronic progressive joint disease.Long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) promotes metastasis cancers and functions as sponge for miR-145.However, the of MALAT1/miR-145 OA pathogenesis has not yet been elucidated. Materials Methods:The expression MALAT1 miR-145 was examined by quantitative real-time PCR; interaction between...
Osteoarthritis (OA) is a degenerative disease that occurs mostly in the elderly, and its specific pathogenesis still unknown, but recent studies have found circular RNA generally display aberrant expression OA. Our study explored characteristics mechanism of action circ-NT5C2 Circ-NT5C2, microRNA-142-5p (miR-142-5p), nicotinamide phosphoribosyltransferase (NAMPT) mRNA levels were measured using RT-qPCR. Western blot was employed to assess protein level NAMPT extracellular matrix (ECM)...