Objectives: Health Technology Assessment (HTA) is defined as a policy research approach that examines the short- and long-term social consequences of application or use technology. Internationally different institutions have translated this definition to local contexts. In Denmark, HTA comprehensive with focus on four aspects problem in question (technology [clinical evidence], economy, patient, organization). The objective study how differs across leading countries extent which Danish...

In the United Kingdom, approximately 10.8 million people suffer from asthma, placing an economic burden on society of more than 2 billion pounds sterling per year. For allergic treatment options consist allergen avoidance, symptomatic and allergen-specific immunotherapy (SIT). Only SIT addresses underlying cause disease, reducing symptoms offering potential for long-term improvement. Grazax--the first tablet-based SIT--is indicated patients with grass pollen-induced rhinoconjunctivitis,...

Background A new 20-valent pneumococcal conjugate vaccine (PCV20) provides protection against 20 serotypes. The has the potential to decrease impact of diseases in society and increase health among vulnerable persons.Aim This study investigates cost-effectiveness vaccinating Danish adults different age groups risk disease with PCV20 compared 23-valent polysaccharide (PPV23) – either as PPV23 or followed by PPV23.Methods Markov model adapted setting was developed estimate clinical outcomes...

In all, 19-22% of the adult Danish population suffer from chronic pain - most frequently in musculoskeletal system. Different management strategies depending on mechanism (neuropathic/nociceptive) make diagnosing condition especially important.To investigate whether a validated, self-administered questionnaire (PainDETECT) helps specialists and general practitioners Denmark identify patients with neuropathic components (NeP).In non-interventional study sample (rheumatologists...

Around 70,000-80,000 Danes suffer from dementia. As average life expectancy increases, the number of people suffering dementia is expected to increase in future with informal care provided by family and friends becoming more important. The aim this study was estimate time spent on persons a Danish setting calculate economic implications.Information collected postal survey members Alzheimer's Association. Data 469 caregivers were obtained corresponding an adjusted response rate 62%.On typical...

Use of oral anticoagulation therapy in patients with atrial fibrillation (AF) involves a trade-off between reduced risk ischemic stroke and an increased bleeding events. Different therapies have different safety profiles data on the societal costs both events are necessary for assessing cost-effectiveness budgetary impact treatment options. To our knowledge, no previous studies estimated AF. The objective this study was to estimate 3-years first-incident intracranial, gastrointestinal other...

The aim of this analysis was to examine the cost-effectiveness Contreet Foam (A) in comparison with three other commonly used venous leg ulcer treatment protocols: Aquacel Ag (B), Actisorb Silver (C) and Iodoflex (D). A health-economic reflecting UK practice cost structure performed. set up assess relative wound area reduction over a 4-week period. model validated by expert panel consisting four care specialists. To assure that had realistic link complete healing, Markov also Sensitivity...

Atrial fibrillation (AF) is a chronic disease with an incidence increasing steeply by age and affecting more than 11 million patients in Europe the United States. Diagnosing AF essential for prevention of stroke oral anticoagulation. Opportunistic screening ≥65 years recommended European Danish Societies Cardiology. The study aim was to examine detection rate consecutively screened primary care setting Denmark. In open, non-interventional, cluster, multicenter, cross-sectional, observational...

There is increasing concern about cardiovascular disease (CVD) after breast cancer (BC). The aim of this study was to estimate the prevalence different types CVD in women diagnosed with BC compared cancer-free controls as well incidence diagnosis.We performed a cohort based on data from national registries covering entire Danish population. We followed 16,505 cancer-naïve patients 2003 2007 5 years before and up 10 diagnosis 165,042 controls.We found that 15.6% were registered at least one...

Studies on the societal burden of patients with biopsy-confirmed non-alcoholic fatty liver disease (NAFLD) are sparse. This study examined this question, comparing NAFLD matched reference groups. Nationwide Danish healthcare registers were used to include all (≥18 years) diagnosed biopsy-verified (1997–2021). Patients classified as having simple steatosis or steatohepatitis (NASH) without cirrhosis, and liver-disease free Healthcare costs labour market outcomes compared from 5 years before...

The recommended first-line treatment for advanced, ER+/HER2 negative breast cancer is a CDK 4/6 inhibitor in combination with an endocrine backbone. This study investigated the use of palbociclib, as first- or second-line therapy advanced patients real-world setting.This retrospective, population-based included all Danish, disease who initiated palbociclib from January 1st, 2017, until December 31st, 2020. primary outcomes were PFS and OS.The 1054 mean age 66.8 years. Median OS was 51.7...

Background: Duchenne Muscular Dystrophy (DMD) is a progressive genetic disease with prevalence of 1 per 3,600–6,000 male births. Individuals DMD are typically diagnosed at age 4–7 years; median survival 30 years. They require multidisciplinary care, personal assistance, and often special education. Objective: The aim was to assess the burden in Denmark. This includes incidence, prevalence, use healthcare services, labour market participation, educational outcomes, overall attributable costs...

Spirometric studies of the general population estimate that 430 000 Danes have chronic obstructive pulmonary disease (COPD). COPD is mainly caused by smoking, and smoking cessation most important intervention to prevent progression. Cost-of-illness conclude costs associated with in Denmark are significant, but prescription medicine for were not analysed.To analyse societal Denmark.The study was designed as a nationwide retrospective register drug (ATC group R03) period 2001-2010. Data...

Detailed evidence on the societal costs of venous thromboembolism (VTE), i.e. deep vein thrombosis (DVT) and pulmonary embolism (PE), subsequent major bleeding events, e.g. intracranial gastrointestinal bleedings, is limited. The objective was to estimate average 3-year event attributable VTE bleedings in Denmark.Based nationwide Danish registers, each incident patient diagnosed with period from 2004 2016 identified matched four non-VTE patients by nearest-neighbour propensity score...

Health care and social costs of pneumonia in Denmark: a register-based study all citizens patients with COPD three municipalities Susanne Lausten Brogaard,1 Maj Britt Dahl Nielsen,1 Lars Ulrik Nielsen,2 Trine Mosegaard Albretsen,3 Morten Bundgaard,4 Niels Anker,1 Maja Appel,1 Kim Gustavsen,1 Rose-Marie Lindkvist,5 Anne Skjoldan,2 Grete Breinhild,3 Peter Bo Poulsen5 1COWI AS, Management - Health, Kongens Lyngby, 2Seniors Department, Gladsaxe Municipality, Welfare Technology, Søborg, 3Elderly...

Glaucoma is a condition affecting one or both eyes with raised intraocular pressure (IOP). IOP should be reduced to prevent progression of visual field loss. This study investigates the cost-effectiveness bimatoprost compared latanoprost as first-line monotherapies in treatment glaucoma Austria, Finland and France. On basis single multicentre, randomised, investigator-masked controlled trial, 6- 12-month model was designed following recommendations from European Society. Treatment changes...

Societal costs due to meningococcal disease: a national registry-based study Nina Gustafsson,1 Sandra Elkjær Stallknecht,1 Mette Skovdal,2 Peter Bo Poulsen,3 Lars Østergaard4 1Incentive, Holte, Denmark; 2Vaccines, Pfizer Denmark, Ballerup, 3Health and Value, 4Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark Purpose: Limited detailed evidence exists on the societal disease. The objective this was estimate average 5-year cost events attributable...

Abstract: Up to 436,000 adult Danes suffer from chronic obstructive pulmonary disease (COPD), with only one third diagnosed at this time. The Danish National Board of Health recommends early detection COPD, focusing on smokers/ex-smokers over 35 years age least lung symptom. A governmental prevention committee has suggested that the municipalities, in addition general practice, should be a potential arena responsible for COPD. We undertook pilot study investigate feasibility and...

Resources devoted to health care are limited, therefore setting priorities is required. It differs between countries whether decision-making concerning technologies focus on broad economic perspectives or narrow single budgets ("silo mentality"). The cost perspective as one part of the full analysis important for decision-making. With case oral anticoagulants in patients with nonvalvular atrial fibrillation (NVAF), aim discuss implication use different and priority setting.In a analysis,...