A5009655769- Nutrition and Health in Aging
- Frailty in Older Adults
- Health Systems, Economic Evaluations, Quality of Life
- Geriatric Care and Nursing Homes
- Cerebral Palsy and Movement Disorders
- Parkinson's Disease Mechanisms and Treatments
- Balance, Gait, and Falls Prevention
- Hip and Femur Fractures
- Palliative Care and End-of-Life Issues
- Chronic Disease Management Strategies
- Body Composition Measurement Techniques
- Stroke Rehabilitation and Recovery
- Clinical Nutrition and Gastroenterology
- Child Nutrition and Feeding Issues
- Dysphagia Assessment and Management
- Obesity and Health Practices
- Nutritional Studies and Diet
- Neurological disorders and treatments
- Grief, Bereavement, and Mental Health
- Healthcare Policy and Management
- Clinical practice guidelines implementation
- Health and Well-being Studies
- Diet and metabolism studies
- Physical Activity and Health
- Pharmaceutical Practices and Patient Outcomes
University of Southampton
2015-2024
Southampton General Hospital
2013-2024
University Hospital Southampton NHS Foundation Trust
2014-2023
National Institute for Health Research
2014-2023
NIHR Southampton Biomedical Research Centre
2013-2023
Wessex Institute of Technology
2019-2023
MaineHealth
2023
NIHR Clinical Research Network
2014-2022
NIHR Applied Research Collaboration West
2021-2022
Collaborative Group (United States)
2021
BackgroundOlder people are increasing users of health care globally. We aimed to establish whether older with characteristics frailty and who at risk adverse health-care outcomes could be identified using routinely collected data.MethodsA three-step approach was used develop validate a Hospital Frailty Risk Score from International Statistical Classification Diseases Related Health Problems, Tenth Revision (ICD-10) diagnostic codes. First, we carried out cluster analysis identify group (≥75...
Inflammaging is characterized by the upregulation of inflammatory response that occurs with advancing age; its roots are strongly embedded in evolutionary theory.Inflammaging believed to be a consequence remodelling innate and acquired immune system, resulting chronic cytokine production.Complex interrelated genetic, environmental age-related factors determine an individual's vulnerability or resilience inflammaging. These include polymorphisms promoter regions cytokines, receptors...
Introduction: sarcopenia is associated with adverse health outcomes. The aim of this study was to describe the prevalence in community-dwelling older people UK using European Working Group on Sarcopenia Older People (EWGSOP) consensus definition. Methods: we applied EWGSOP definition 103 men participating Hertfordshire Study (HSS) both lowest third dual-energy X-ray absorptiometry (DXA) lean mass (LM) and skin-fold-based fat-free (FFM) as markers low muscle mass. We also used FFM approach...
Objective: to investigate the relationship between grip strength and health-related quality of life (HRQoL). Design: cross-sectional survey within a cohort study design. Setting: county Hertfordshire in UK. Participants: total 2,987 community-dwelling men women aged 59–73 years age. Measurements: was used as marker sarcopaenia measured using Jamar dynamometer. HRQoL assessed eight domain scores Short Form-36 (SF-36) questionnaire, subjects lowest sex-specific fifth distribution were...
Poor appetite is a common problem in older people living at home and care homes, as well hospital inpatients. It can contribute to weight loss nutritional deficiencies, associated poor healthcare outcomes, including increased mortality. Understanding the causes of reduced knowing how measure it will enable nurses other clinical staff working range community settings identify patients with impaired appetite. A strategies be used promote better increase food intake.
Background: frailty, a multi-dimensional geriatric syndrome, confers high risk for falls, disability, hospitalisation and mortality. The prevalence correlates of frailty in the UK are unknown. Methods: defined by Fried, was examined among community-dwelling young-old (64–74 years) men (n = 320) women 318) who participated Hertfordshire Cohort Study, UK. Results: 8.5% 4.1% (P 0.02). Among men, older age 0.009), younger leaving education 0.05), not owning/mortgaging one's home (odds ratio [OR]...
Handgrip strength is a non-invasive marker of muscle strength, and low grip in hospital inpatients associated with poor healthcare outcomes including longer length stay, increased functional limitations, mortality. Measuring simple inexpensive. However, measurement not routinely used clinical practice. The aim this study to evaluate the feasibility implementing into routine practice.This mixed methods design combining qualitative, quantitative, economic elements based on acute medical wards...
We and others have described the neurodegenerative disorder caused by G51D SNCA mutation which shares characteristics of Parkinson’s disease (PD) multiple system atrophy (MSA). The objective this investigation was to extend description clinical neuropathological hallmarks mutant SNCA-associated study two additional cases from a further kindred compare features group with duplication case H50Q case. All three patients were clinically characterised parkinsonism, dementia, visual...
'Frailty crises' are a common cause of hospital admission among older people and there is significant focus on avoidance. However, identifying frailty before crisis occurs challenging, making it difficult to effectively target community services. Better longer-term outcome data needed if services reflect the needs growing population with frailty.To determine long-term outcomes discharged from following short (<72 hours) longer admissions compared by status.Two populations aged ≥70 years...
Many older people with frailty are at risk of malnutrition and poor health, yet there is evidence that improving nutrition weight loss can reduce frailty. This will become more important as the number increases worldwide in future. Identifying those challenging due to difficulty reaching screening most risk, large nutritional assessment tools used, lack consensus on criteria make a diagnosis malnutrition. The management or should be multi-modal multi-disciplinary, all care staff have an role...
Background People with Parkinson’s disease are twice as likely to experience a fall healthy older person, often leading debilitating effects on confidence, activity levels and quality of life. Objective To estimate the effect physiotherapy programme for prevention among people disease. Design A multicentre, pragmatic, investigator-masked, individually randomised controlled trial (RCT) prespecified subgroup analyses. Setting Recruitment from NHS hospitals clinics community social services in...
To estimate the effect of a physiotherapist-delivered fall prevention programme for people with Parkinson's (PwP).
Background: low muscle strength is central to geriatric syndromes including sarcopenia and frailty. It well described in community-dwelling older people, but the epidemiology of grip people rehabilitation or long-term care has been little explored. Objective: describe nursing home settings. Design: cross-sectional epidemiological study. Setting: three healthcare settings one town. Subjects: hundred inpatients on a ward, 47 community referrals 100 residents. Methods: strength, age, height,...