A5100745848- Nanoplatforms for cancer theranostics
- Lignin and Wood Chemistry
- Catalysis and Hydrodesulfurization Studies
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Catalysis for Biomass Conversion
- Sulfur Compounds in Biology
- Polymer-Based Agricultural Enhancements
- Nanomaterials for catalytic reactions
- Metal-Organic Frameworks: Synthesis and Applications
- Cancer, Hypoxia, and Metabolism
- Dendrimers and Hyperbranched Polymers
- Biosensors and Analytical Detection
- Photodynamic Therapy Research Studies
- Asymmetric Hydrogenation and Catalysis
- Nanocomposite Films for Food Packaging
- CNS Lymphoma Diagnosis and Treatment
- Electrophoretic Deposition in Materials Science
- Plant Surface Properties and Treatments
- Advanced biosensing and bioanalysis techniques
- Carbon and Quantum Dots Applications
- Ovarian cancer diagnosis and treatment
- RNA Interference and Gene Delivery
- Surface Modification and Superhydrophobicity
- Luminescence and Fluorescent Materials
Shenyang Pharmaceutical University
2020-2024
East China University of Science and Technology
2019-2024
Sylvester Comprehensive Cancer Center
2019
University of Miami
2019
Tsinghua University
2017-2019
Xi'an Jiaotong University
2019
Dimeric prodrug nanoassemblies (DPNAs) stand out as promising strategies for improving the efficiency and safety of chemotherapeutic drugs. The success trisulfide bonds (-SSS-) in DPNAs makes polysulfide a worthwhile focus. Here, we explore comprehensive role tetrasulfide (-SSSS-) constructing superior DPNAs. Compared to disulfide bonds, endow with superlative self-assembly stability, prolonged blood circulation, high tumor accumulation. Notably, ultra-high reduction responsivity make highly...
Lignin is constructed from methoxylated phenylpropanoid with plenty of hydroxys and methoxys. Its conversion to valuable products extremely attractive but especially challenging without additional hydrogen sources. Herein we report a hydrogen-free production 4-alkylphenols directly native lignin via self-reforming-driven depolymerization hydrogenolysis over Pt/NiAl2O4. This the first example acquiring lignin. Using this strategy, high yields 4-alkylphenols, 17.3 wt %, were obtained birch...
Abstract Sulfur bonds, especially trisulfide bond, have been found to ameliorate the self-assembly stability of homodimeric prodrug nanoassemblies and could trigger sensitive reduction-responsive release active drugs. However, antitumor efficacy with single reduction-responsivity may be restricted due heterogeneous tumor redox microenvironment. Herein, we replace middle sulfur atom bond an oxidizing tellurium or selenium construct dual-responsive sulfur-tellurium-sulfur...
Avermectin (AVM) is a low-toxic and high-active biopesticide, but it can be easily degraded by UV light. In this paper, biodegradable castor oil-based polyurethanes (CO-PU) are synthesized used as carriers to fabricate new kind of AVM/CO-PU nanoemulsion through an emulsion solvent evaporation method, the chemical structure, colloidal property, AVM loading capacity, controlled-release behavior, foliar adhesion, photostability drug delivery systems investigated. Results show that physically...
Prodrug-nanoparticles turn the disadvantage of aggregation-caused quenching effect into an advantage to promote dual-modality PR104A release. Besides, photodynamic therapy-induced hypoxia activates for high-efficiency synergistic therapy.
Nucleic acid lateral flow assays (NALFAs) have attracted much attention due to their rapid, robust, simple, and cost-effective features. However, the current NALFAs are still limited by low sensitivity because of poor understanding control underlying complex reaction processes. Although enormous efforts been devoted enhancing detection NALFAs, developing simple with high remains difficult. Thus, we proposed a novel physical–chemical coupling method using dissoluble saline barriers developed...
Abstract Demethoxylation was kinetically and spectroscopically studied over three catalysts with different Ru 0 /Ru δ+ ratios. In-situ spectroscopic tests demonstrated that the synergy between crucial, in charge of H 2 activation adsorption aromatic ring while adsorbed O methoxyl. A Langmuir–Hinshelwood kinetic model proposed, ratio key deciding rate-determining step (RDS): i) desorption toluene RDS catalyst high ratio; ii) dissociation enriched catalyst; iii) demethoxylation rate-determined...
Inefficient usage and overdosage of conventional pesticide formulations has resulted in large economic losses environmental pollution due to their poor water solubility weak adhesion foliage. In order develop a green efficient formulation, kind alkyd resin (AR) based on vegetable oil was first synthesized used fabricate the lambda-cyhalothrin/AR (LC/AR) nanoemulsion via situ phase inverse emulsification, its properties were then investigated. Results showed that particle size LC/AR 50–150 nm...
Previously, we found that, by self-reforming-driven hydrogenolysis of lignin or oils, 4-alkylphenols can be produced directly under hydrogen-free conditions over Pt//NiAl2O4 catalyst (ACS Catal. 2020, 10, 15197–15206). That work mainly focused on the exploration a new strategy and reaction pathways hydrogen contained in during its valorization. In this work, use M/NiAl2O4 (M = Pt, Pd, Ru) catalysts to investigate rate-determined step, structure–activity relationships, adsorbed species,...
The unique characteristics of the tumor microenvironment (TME) could be exploited to develop antitumor nanomedicine strategies. However, in many cases, actual therapeutic effect is far from reaching our expectations due notable heterogeneity. Given amplified TME regulated by vascular disrupting agents (VDAs), nanomedicines may achieve unexpected improved efficacy. Herein, we fabricate platelet membrane-fusogenic liposomes (PML/DP&PPa), namely "platesomes", which actively load...
The size effect of Ru/NiAl 2 O 4 catalysts on the self-reforming-driven hydrogenolysis a lignin model compound is investigated.
Diffuse large B cell lymphoma (DLBCL) is an aggressive non-Hodgkin and the most frequently diagnosed hematologic malignancy in United States. DLBCL exhibits significant molecular clinical heterogeneity, at least a third of patients are left uncured with standard frontline chemoimmunotherapy. As such, there critical need to identify novel targeted therapies improve outcomes. We conducted phenotypic screen kinase inhibitors against lines non-malignant controls. identified cyclin G-associated...
<p>Supplemental Figures 1-9. Figure S1. Carbon-Nitride Dot Synthesis. S2. Characterization of CND-Dox-TF. S3. CND cytotoxicity. S4. Cell surface TFR1 expression and receptor recycling. S5. Rapid nuclear entry by Dox after CND-Dox-TF treatment in DLBCL. S6. HEK293 is a model cell line for elucidating mechanism. S7. working dose identified. S8. has improved toxicity profile compared to Dox. S9. R-nanoCHOP favorable non-malignant organs.</p>
<p>Supplemental Figures 1-9. Figure S1. Carbon-Nitride Dot Synthesis. S2. Characterization of CND-Dox-TF. S3. CND cytotoxicity. S4. Cell surface TFR1 expression and receptor recycling. S5. Rapid nuclear entry by Dox after CND-Dox-TF treatment in DLBCL. S6. HEK293 is a model cell line for elucidating mechanism. S7. working dose identified. S8. has improved toxicity profile compared to Dox. S9. R-nanoCHOP favorable non-malignant organs.</p>
Demethoxylation was kinetically and spectroscopically studied over three catalysts with different Ru0/Ruδ+ ratios. In-situ spectroscopic tests demonstrated that the synergy between Ru0 Ruδ+ crucial, in charge of H2 activation adsorption aromatic ring while adsorbed O methoxyl. A Langmuir-Hinshelwood kinetic model proposed, ratio key deciding rate-determining step (RDS): i) desorption toluene RDS catalyst high ratio; ii) dissociation enriched catalyst; iii) demethoxylation rate-determined by...