A5015257377- Mosquito-borne diseases and control
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Virology and Viral Diseases
- vaccines and immunoinformatics approaches
- COVID-19 Clinical Research Studies
- Insect symbiosis and bacterial influences
- SARS-CoV-2 detection and testing
- Animal Virus Infections Studies
- COVID-19 and healthcare impacts
- Dermatological and COVID-19 studies
- Plant Virus Research Studies
Instituto Nacional de Salud
2019-2023
Ministry of Health and Social Protection
2021
Summary The genetic diversity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has the potential to impact virus transmissibility and escape from natural infection- or vaccine-elicited neutralizing antibodies. Here, representative samples circulating SARS-CoV-2 in Colombia between January April 2021, were processed for genome sequencing lineage determination following nanopore amplicon ARTIC network protocol PANGOLIN pipeline. This strategy allowed us identify emergence...
A Zika virus (ZIKV) strain was isolated from an acute febrile patient during the epidemics in Colombia. The intraperitoneally inoculated into BALB/c mice, and 7 days postinoculation, neurological manifestations ZIKV infection brain were demonstrated. reported genome sequence is highly related to strains circulating Americas.
Zika virus (ZIKV) disease continues to be a threat public health, and it is estimated that millions of people have been infected there more cases serious complications than those already reported. Despite many studies on the pathogenesis ZIKV, several genes involved in malformations associated with viral infection are still unknown. In this work, morphological molecular changes cortex cerebellum mice ZIKV were evaluated. Neonatal BALB/c inoculated intraperitoneally, respective controls...
COVID-19 pandemics has led to genetic diversification of SARS-CoV-2 and the appearance variants with potential impact in transmissibility viral escape from acquired immunity. We report a new highly divergent lineage containing 21 distinctive mutations (10 non-synonymous, eight synonymous, three substitutions non-coding regions). The amino acid changes L249S E484K located at CTD RBD Spike protein could be special interest due their biological role virus-host relationship. Further studies are...
Abstract COVID-19 pandemics has led to genetic diversification of SARS-CoV-2 and the appearance variants with potential impact in transmissibility viral escape from acquired immunity. We report a new lineage containing ten distinctive amino acid changes across genome. Further studies are required for monitoring its epidemiologic impact.
In the first descriptions of histopathological findings SARS-CoV-2, diffuse alveolar damage, hyaline membrane formation and vascular congestion, hemorrhage fibrinoid deposits in intra-alveolar space, inflammatory mononuclear cell infiltration, edema, interstitial fibrosis,