A5091420028- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Virology and Viral Diseases
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and healthcare impacts
- Global Maternal and Child Health
- SARS-CoV-2 detection and testing
- Cardiac, Anesthesia and Surgical Outcomes
- Trauma and Emergency Care Studies
- Insect symbiosis and bacterial influences
- Advanced biosensing and bioanalysis techniques
- Cytomegalovirus and herpesvirus research
- COVID-19 epidemiological studies
- COVID-19 diagnosis using AI
- Inflammation biomarkers and pathways
- Malaria Research and Control
- Surgical site infection prevention
- Respiratory viral infections research
- Healthcare cost, quality, practices
- Herpesvirus Infections and Treatments
- Public Health and Environmental Issues
- Kawasaki Disease and Coronary Complications
- Animal Virus Infections Studies
- Assisted Reproductive Technology and Twin Pregnancy
- Viral Infections and Outbreaks Research
Barcelona Institute for Global Health
2024
Instituto Nacional de Salud
2015-2023
Universidad Nacional de Colombia
2016-2020
University of Guelph
2006
Autonomous University of Chihuahua
2006
Colombia began official surveillance for Zika virus disease (ZVD) in August 2015. In October 2015, an outbreak of ZVD was declared after laboratory-confirmed identified nine patients.Using the national population-based system, we assessed patients with clinical symptoms from 9, to April 2, 2016. Laboratory test results and pregnancy outcomes were evaluated a subgroup pregnant women. Concurrently, investigated reports microcephaly evidence congenital ZVD.By 2016, there 65,726 cases reported...
Our objective was to determine the frequency of zika (ZIKV), chikungunya (CHIKV) and dengue (DENV) virus coinfection describe mortality cases that occurred during epidemiologic surveillance ZIKV epidemic in Colombia. We analysed all suspected infection were reported National Institute Health (October 2015-December 2016). DENV, CHIKV RNA detected serum or tissue samples using polymerase chain reaction assay. Medical records fatal reviewed. identified 23 871 processed. The viral agents 439...
In 2015 and 2016, Colombia had a widespread outbreak of Zika virus. Data from two national population-based surveillance systems for symptomatic virus disease (ZVD) birth defects provided complementary information on the effect pregnancies infant outcomes.We collected data regarding cases pregnant women with ZVD that were reported during period June through July 2016. The presence RNA was identified in subgroup these real-time reverse-transcriptase-polymerase-chain-reaction (rRT-PCR) assay....
<h3>Importance</h3> Congenital Zika syndrome (CZS) is known to be associated with severe malformations in newborns. Although microcephaly the hallmark of this disease, ocular findings are important given visual impairment that has been observed these patients. Regardless increased number CZS cases reported, date, no studies have described histopathologic entity. <h3>Objectives</h3> To evaluate presence virus (ZIKV) antigens and describe features 4 CZS. <h3>Design, Setting, Participants</h3>...
We report clinical features and histopathological findings in fatal cases with dengue (DENV) chikungunya (CHIKV) co-infection identified at the Colombian National Institute of Health between September 2014 October 2015. Seven such were documented. Dengue serotype 2 virus was six cases. All patients adults comorbidities present four. Fever, arthralgia or myalgia all The frequency rash, haemorrhage, oedema, gastrointestinal symptoms variable. Laboratory as thrombocytopenia, renal failure,...
We performed phylogenomic analysis of severe acute respiratory syndrome coronavirus-2 from 88 infected individuals across different regions Colombia. Eleven lineages were detected, suggesting multiple introduction events. Pangolin B.1 and B.1.5 the most frequent, with being associated prior travel to high-risk areas.
Since its emergence in Wuhan (China) on December 2019, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has rapidly spread worldwide. After arrival South America February 2020, virus expanded throughout region, infecting over 900,000 individuals with approximately 41,000 reported deaths to date. In response growing number of cases, a different primer-probe sets have been developed. However, despite being highly specific, most these are known exhibit variable sensitivity....
Background Acute undifferentiated febrile illness is a common challenge for clinicians, especially in tropical and subtropical countries. Incorrect or delayed diagnosis of patients may result medical complications preventable deaths. Common causes acute Colombia include leptospirosis, rickettsioses, dengue fever, malaria, chikungunya, Zika virus infection. In this study, we described the postmortem reported as suspected cases leptospirosis through national surveillance Colombia, 2016–2019....
Abstract Background Children are considered a potentially vulnerable population for Zika virus infection. However, data on paediatric infection sparse. Methods We analysed from Colombia's national surveillance system during the 2015–2016 outbreak patients meeting clinical case definition of disease ( ZVD ) among children aged 1 month to 18 years estimate incidence by demographic characteristics and characterize occurrence selected complications. Results Between August 14, 2015, May 28, 2016,...
Abstract The ongoing severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic has led to the design and development of multiple reverse‐transcription polymerase chain reaction kits aimed facilitate rapid scale‐up molecular testing for massive screening. We evaluated diagnostic performance nine commercial kits, which showed optimal high discriminatory power. However, we observed differences in terms sensitivity, specificity, E gene Ct Values discuss these results light influence...
Project Vigilancia de Embarazadas con Zika (VEZ), an intensified surveillance of pregnant women with symptoms the virus disease (ZVD) in Colombia, aimed to evaluate relationship between ZVD during pregnancy and adverse pregnancy, birth, infant outcomes early childhood neurodevelopmental outcomes. During May–November 2016, three Colombian cities who were reported national system, or visiting participating clinics, enrolled VEZ. Data from maternal pediatric (up two years age) medical records...
We assessed maternal and infant cytomegalovirus (CMV) infection in Colombia. Maternal serum was tested for CMV immunoglobulin G antibodies at a median of 10 (interquartile range: 8-12) weeks gestation (n = 1501). DNA polymerase chain reaction performed on urine to diagnose congenital (≤21 days life) postnatal (>21 days) infection. seroprevalence 98.1% (95% confidence interval [CI]: 97.5%-98.8%). Congenital prevalence 8.4 CI: 3.9%-18.3%; 6/711) per 1000 live births. Among 472 infants without...
Colombia was the second most affected country during American Zika virus (ZIKV) epidemic, with over 109,000 reported cases. Despite scale of outbreak, limited genomic sequence data were available from Colombia. We sought to additional samples and use epidemiology describe ZIKV dynamics in Colombia.We sequenced genomes directly clinical diagnostic specimens infected Aedes aegypti selected cover temporal geographic breadth Colombian outbreak. performed phylogeographic analysis these genomes,...
<p><strong>Introducción.</strong> El virus del chikungunya, perteneciente al género <em>Alphavirus</em> de la familia Togaviridae, es un ARN 11,8 kb, cadena sencilla y polaridad positiva, transmitido por <em>Aedes</em> spp. Se han identificado tres genotipos a nivel mundial: el Asia, este-centro-sur África (<em>East/Central/South African</em>, ECSA) occidental (<em>West WA). La fiebre chikungunya una enfermedad febril aguda,...
Abstract Since its emergence in Wuhan (China) on December 2019 the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has rapidly spread worldwide. After arrival South America February 2020 virus expanded throughout region infecting over 900,000 individuals with approximately 41,000 reported deaths to date. In response growing number of cases, a different primer-probe sets have been developed. However, despite being highly specific most these are known exhibit variable sensitivity....
Chikungunya virus (CHIKV) infection is an emerging arboviral disease that has spread geographically to many previously unaffected areas. Although severe cases of acute CHIKV have been documented, little known about its pathogenesis. We aimed determine the levels cardiovascular biomarkers in fatal and non-fatal patients with infection. This study included reported National System for Public Health Surveillance laboratory-confirmed by Colombian Institute Health. Each patient was matched 2 age...
A Zika virus (ZIKV) strain was isolated from an acute febrile patient during the epidemics in Colombia. The intraperitoneally inoculated into BALB/c mice, and 7 days postinoculation, neurological manifestations ZIKV infection brain were demonstrated. reported genome sequence is highly related to strains circulating Americas.
ObjectivesTo evaluate the genomic epidemiology of SARS-CoV-2 from Venezuelan migrants living in Colombia.MethodsThis study sequenced 30 clinical specimens collected migrants. Genomes were compared with Wuhan reference genome to identify polymorphisms, reconstruct phylogenetic relationships and perform comparative analyses. Geographic, sociodemographic data also studied across genotypes.ResultsThis demonstrated presence six distinct lineages circulating among migrants, as well a close...
ABSTRACT We performed phylogenomic analysis of severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) from 88 infected individuals across different regions Colombia. Eleven lineages were detected, suggesting multiple introduction events. Pangolin B.1 and B.1.5 the most frequent, with being associated prior travel to high-risk areas. Article Summary Line sequenced genomes SARS-CoV2 Colombia finding 11 eight events
Prenatal exposure to Zika virus (ZIKV) is associated with congenital anomalies of the brain and eye neurodevelopmental sequelae. The spectrum disease outcomes may relate timing infection as well genetic environmental factors. Congenital infections occurring in twin pregnancies can inform clinical these conditions provide unique information regarding utero environment pathophysiology. Herein, we report a monozygotic dichorionic-diamniotic pregnancy probable prenatal ZIKV identified through...
ABSTRACT. Zika virus (ZIKV) infection in pregnancy is associated with severe abnormalities of the brain and eye other adverse outcomes. en Embarazadas y Niños was a prospective cohort study conducted multiple Colombian cities that enrolled pregnant women their first trimester. Specimens collected from ( n = 1,519) during February 2017–September 2018 infants 1,080) June 2017–March 2019 were tested for prenatal ZIKV by nucleic acid amplification tests or IgM antibody testing. present 3.2%...