A5089867054- Cell Image Analysis Techniques
- Congenital heart defects research
- Angiogenesis and VEGF in Cancer
- Zebrafish Biomedical Research Applications
- 3D Printing in Biomedical Research
- Hemostasis and retained surgical items
- Marine animal studies overview
- Congenital Heart Disease Studies
- RNA Research and Splicing
- Vascular Malformations and Hemangiomas
- Mathematical Biology Tumor Growth
- Developmental Biology and Gene Regulation
- Renal and related cancers
- Single-cell and spatial transcriptomics
- Cellular Mechanics and Interactions
- Aortic Disease and Treatment Approaches
- Vascular Anomalies and Treatments
- Mesenchymal stem cell research
Max Delbrück Center
2023-2025
German Centre for Cardiovascular Research
2023-2025
Charité - Universitätsmedizin Berlin
2023-2024
Tel Aviv University
2017-2023
Importance Nonsyndromic bicuspid aortic valve (nsBAV) is the most common congenital heart malformation. BAV has a heritable component, yet only few causative genes have been identified; understanding genetics key point in developing personalized medicine. Objective To identify new gene for nsBAV. Design, Setting, and Participants This was comprehensive, multicenter, genetic association study based on candidate prioritization familial cohort followed by rare studies replication cohorts....
Abstract Cell polarity involves the asymmetric distribution of cellular components such as signalling molecules and organelles within a cell, alterations in cell morphology cell-cell contacts. Advances fluorescence microscopy deep learning algorithms open up wealth unprecedented opportunities to characterise various aspects polarity, but also create new challenges for comprehensible interpretable image data analysis workflows fully exploit these opportunities. Here we present Polarity-JaM,...
Abstract Hereditary hemorrhagic telangiectasia is an autosomal dominant disorder caused by mutations in the bone morphogenetic protein signaling pathway, leading to arteriovenous malformations. While previously thought share molecular and cellular dysregulation, this study reveals highly distinct mechanisms depending on whether occur Alk1 or SMAD4. Loss of SMAD4 enhances endothelial cell responses flow, including flow-regulated transcription migration against blood causing excessive pruning...
Cell polarity involves the asymmetric distribution of cellular components such as signaling molecules and organelles within a cell, asymmetries cell”s shape well contacts with neighbouring cells. Gradients mechanical forces often act global cues that bias cell orientation, is coordinated by communication between adjacent Advances in fluorescence microscopy combined deep learning algorithms for image segmentation open up wealth possibilities to understand behaviour health disease. We have...
Abstract Emerging concepts of developmental vascular remodelling recently identified that selectively labelled sprouting tip cells and/or venous endothelial (ECs) accumulate in developing arteries, suggesting directional migration specific ECs drives artery formation. However, a general population analysis and detailed quantitative investigation migratory mechanisms is so far lacking. Here, we developed universally applicable approach computational model allowing to track simulate...
Fetal Bovine Serum contains traces of ligands the BMP pathway which affect flow experiments with ibidi perfusion system. replacing EGM2 2% 0.1% BSA 4h prior to onset (with same media) allows cells respond better and collectively flow.