A5046095799- Renal Transplantation Outcomes and Treatments
- Xenotransplantation and immune response
- Organ Transplantation Techniques and Outcomes
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Metabolism and Genetic Disorders
- Organ and Tissue Transplantation Research
- Electrolyte and hormonal disorders
- Chemokine receptors and signaling
- Renal and Vascular Pathologies
- Cardiac, Anesthesia and Surgical Outcomes
- Immune Response and Inflammation
- Mobile Health and mHealth Applications
- Obesity and Health Practices
- Renal Diseases and Glomerulopathies
- Bariatric Surgery and Outcomes
- Reproductive System and Pregnancy
- S100 Proteins and Annexins
- Viral Infections and Vectors
- Angiogenesis and VEGF in Cancer
- Synthesis and biological activity
- Physical Activity and Health
- interferon and immune responses
- Pregnancy and Medication Impact
- Monoclonal and Polyclonal Antibodies Research
Swedish Medical Center
2017-2020
Swedish Medical Center
2019-2020
National Alliance of Healthcare Purchaser Coalitions
2019
Obesity Medicine Association
2019
Providence Health & Services
2019
Umeå University
2013-2014
UConn Health
1974-2000
University of Connecticut
1973-1992
CheminPharma (United States)
1991
The Ohio State University
1983
Objective The development of these updated clinical practice guidelines (CPGs) was commissioned by the American Association Clinical Endocrinologists (AACE), Obesity Society (TOS), for Metabolic and Bariatric Surgery (ASMBS), Medicine (OMA), Anesthesiologists (ASA) Boards Directors in adherence with AACE 2017 protocol standardized production CPGs, algorithms, checklists. Methods Each recommendation evaluated based on new evidence from 2013 to present subjective factors provided experts....
An experimental study of inbred rat kidney transplantation across a strong histocompatibility barrier has been described. Effective renal plasma flow measured by the disappearance rate 125I-ortho-iodohippurate is normal at day 3 after allotransplantation and decreased 5 with little or no urine formation allograft on 7. Serum β10-globuIin levels in allografted rats are higher than control isografted animals during 2nd 3rd week transplantation. Donor specific agglutinating cytotoxic antibody...
Background: Using technology to self-monitor body weight, dietary intake, and physical activity is a common practice used by consumers health companies increase awareness of current desired behaviors in weight loss. Understanding how best use the information gathered these relatively new methods needs be further explored. Objective: The purpose this study was analyze contribution self-monitoring loss participants 6-month commercial weight-loss intervention administered Retrofit specifically...
ABSTRACT Vector-borne flaviviruses, such as tick-borne encephalitis virus (TBEV), West Nile virus, and dengue cause millions of infections in humans. TBEV causes a broad range pathological symptoms, ranging from meningitis to severe or even hemorrhagic fever, with high mortality. Despite the availability an effective vaccine, incidence is increasing. Not much known about role innate immune system control infections. Here, we show that type I interferon (IFN) essential for protection against...
SUMMARY In an investigation of the genesis perivascular mononuclear cell infiltrates and subsequent tissue damage in unmodified renal allograft rejection using cyclophosphamide-treated bone marrowgrafted rats parental strain to F1 hybrid transplants, it is shown that: (1) interaction donor recipient genetically dissimilar hematopoietic lines, part donor-organ lymphocytes, that generates proliferative reaction cortical interstitium; (2) abrogation this significantly prevents vascular tubular...
Heterologous rabbit anti-rat thymocyte sera, its immunoglobulin G fraction, and the bivalent univalent antibody fragments obtained by pepsin digestion are potent immunosuppressive reagents when tested in a system of renal allotransplantation between LBN F1 hybrid Lewis rat strains. The AT F(ab')2 is not lymphocytotoxic vitro but has agglutinating ability, while Fab' neither agglutinates nor cytotoxic to lymphocytes, will inhibit reaction. IgG more immunogenic their host than normal F(ab')2,...
We hypothesize that interleukin-1α, β, and receptor antagonist (IL-1α, IL-1β, IL-1ra, respectively) are present tumor cell associated in human breast cancer (HBC). believe the levels of these cytokines homogenates relate to other known prognosticators patient survival (i.e., estrogen [ER] status). Our results demonstrated that, immunohistochemically, cells express IL-1α, IL-1ra most specimens tested. In tissue homogenates, IL-1α correlated inversely with ER (p < 0.06), whereas directly both...
SUMMARY In a renal allograft system crossing major immunogenetic barrier where acute rejection leads uniformly to nonfunctioning kidney in 7 days, it is shown that pretreating the donor of with high doses cyclophosphamide, methotrexate, or procarbazine markedly reduces pattern organ significant number untreated recipients. This effect considered be caused by reduction graft immunogenicity following destruction nonparenchymal cells hematopoietic origin which are stimuli effector mechanisms...
THE varieties of congenital myopathy include muscular glycogenosis, megaconial and pleoconial myopathies, dystrophy, central core disease, benign hypotonia, nemaline myopathy.<sup>1</sup>The purpose this communication is to report an infant dying with a which was characterized by morphologic feature not previously described in any known case. Skeletal muscle from patient contained numerous eosinophilic intranuclear crystalline inclusions were seen on routine hematoxylin eosin stained...
SUMMARY When renal allografting is performed in inbred rats across a strong histocompatibility barrier, the administration of as few 107 donor strain nucleated marrow cells single i.v. injection to recipients at an optimal time prior allotransplantation consistently produces marked suppression tempo rejection. Normal function seen 7 days following allotransplantation, when unmodified recipient has essentially no function. Histological evidence rejection diminished well. Recipients treated...
SUMMARY Using two inbred strains of rats, (Lewis X Fischer) F1 hybrid as donors and Lewis recipients, we have performed 82 renal allotransplants to study the functional morphological characteristics allograft rejection in this experimental model. The prolonged survival allografts nonsensitized recipients is marked contrast prompt skin grafts same donorrecipient combination. early variability function usually stabilizes within normal range; presensitized with donor strain grafts, effective...
Providing coaches as part of a weight management program is common practice to increase participant engagement and loss success. Understanding coach interactions how these impact success needs be further explored for coaching best practices.The purpose this study was analyze the interaction in 6-month intervention administered by Retrofit, personalized Web-based disease prevention solution. The specifically examined association between different methods coach-participant tried understand...
Quantitative data obtained from the study of a complex heteroantisera in an immunogenetically controlled renal allotransplant system has been presented. Antithymus serum is potent immunosuppressive agent, potentially nephritogenic by mechanisms “planted antigen” and antigen-antibody deposit many specificities. Animals treated with heterosera show immune elimination rates when given trace radio-labeled amounts foreign protein antigen. Organ localization isotopic fluorescent tracers are...
SUMMARY The mechanism of the suppression rejection and consequent indefinite survival renal allografts in inbred rats, produced by a single i.v. injection donor strain marrow cells, optimal number time prior to allotransplantation across strong histocompatibility barrier, was investigated. Immunological tolerance is not involved, for (1) some morphological evidence present these grafts; (2) animals bearing normally functioning rejected skin grafts normal fashion; (3) spleen cells were...
Arteriography in kidney transplantation has been recently reviewed by Weidner et al. (1). The importance of donor arteriography was stressed these authors and is self-evident when one considers the frequency multiple renal arteries unsuspected vascular disease, either which may eliminate potential donors. role preoperative evaluation recipient less clear and, absence other evidence often unnecessary. Of more recent interest assessing transplants immediate postoperative period during bouts...
SUMMARY The effects of three, immunosuppressive chemicals on renal allograft rejection in rats were assayed m a genetically controlled transplantation system. Each the three drugs influenced morphological features rejecting different and highly characteristic manner. Of used, cyclophosphamide was most effective modifying all pathological as well preserving function. Methylprednisolone therapy resulted significant preservation function hut associated with incidence death, presumably from...
Nonspecific target cells were bound to alloimmune cytolytic T lymphocytes (CTL) by either wheat germ agglutinin or immunoglobulin and evidence of nonspecific cell killing was sought the 51Cr-release method. None found. Thus, merely "gluing" CTL is not sufficient effect destruction. In order determine if mechanisms CTL, once triggered, would kill adhering cells, with mixed specific targets. Under these conditions killed but virtue bridges not. when antigen-specific receptors on interact...
Rabbit antirat thymoeyte serum (ATS) was injected i.v. into Lewis rats whose kidneys were examined for glomerular alterations by light, electron, and immunofluorescent microscopy. Glomerular evident in with ATS, ATS absorbed rat red cells proteins, or the purified IgG fraction of (AT-IgG) over a 5–12-day period total 6–25 mg AT-IgG its equivalent. Expansion mesangia principal light microscopic alteration. absorbed, administration associated decreasing severity, respectively. Electron...