A5024916484- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Liver physiology and pathology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hepatitis B Virus Studies
- Kruppel-like factors research
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Liver Disease and Transplantation
- Pancreatic function and diabetes
- Organ Transplantation Techniques and Outcomes
- Gastrointestinal disorders and treatments
- Systemic Lupus Erythematosus Research
- Eosinophilic Disorders and Syndromes
- Lymphoma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Inflammatory Bowel Disease
- Cancer, Hypoxia, and Metabolism
- Liver Diseases and Immunity
- Neuroendocrine Tumor Research Advances
- Pediatric Hepatobiliary Diseases and Treatments
- Diverticular Disease and Complications
- Amoebic Infections and Treatments
- Cancer Genomics and Diagnostics
- Folate and B Vitamins Research
University of Miyazaki
2013-2024
University of Miyazaki Hospital
2023
Weatherford College
2022
Miyazaki Welfare Medical College
2001-2004
Kagawa Prefectural College of Health Sciences
2003
d–Galactosamine (GalN)/lipopolysaccharide (LPS)–induced liver injury is an experimental model of fulminant hepatic failure in which tumor necrosis factor α (TNF–α) plays a pivotal role. We examined the effects etoposide on GalN/LPS–induced failure. Mice were given intraperitoneal dose GalN (800 μg/g body weight)/LPS (100 ng/g weight) with and without (10 treatment. Liver was assessed biochemically histologically. TNF–α levels serum, apoptosis hepatocytes CPP32/caspase–3 liver, determined....
Mutations of calreticulin (CALR) are detected in 25–30% patients with essential thrombocythemia (ET) or primary myelofibrosis and cause frameshifts that result proteins a novel C-terminal. We demonstrate CALR mutations activated signal transducer activator transcription 5 (STAT5) 293T cells the presence thrombopoietin receptor (MPL). Human megakaryocytic CMK11-5 erythroleukemic F-36P-MPL knocked-in showed increased growth acquisition cytokine-independent growth, respectively, accompanied by...
The overall mortality of patients infected with hepatitis C virus (HCV) has not been fully elucidated. This study analyzed in subjects positive for antibody to HCV (anti-HCV) a community-based, prospective cohort conducted an hyperendemic area Japan. During 10-year period beginning 1995, 1125 anti–HCV-seropositive residents Town were enrolled into the and followed through 2005. Cause death was assessed by certificates. Subjects detectable core antigen (HCVcAg) or RNA considered as having...
Abstract Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) characterized by clonal myeloproliferation, progressive bone marrow (BM) fibrosis, splenomegaly, and anemia. BM fibrosis was previously thought to be reactive phenomenon induced mesenchymal stromal cells that are stimulated the overproduction of cytokines such as transforming growth factor (TGF)-β1. However, involvement neoplastic fibrocytes in recently reported. In this study, we showed vast majority collagen-...
Early detection of HCC increases the potential for curative treatment and improves survival. To facilitate early HCC, this study sought to identify novel diagnostic markers using surface-enhanced laser desorption ionization time-of-flight mass spectrometry (SELDI-TOF/MS) ProteinChip technology. Serum samples were obtained from 153 patients with or without all whom had been diagnosed HCV-associated chronic liver disease. proteins associated serum analyzed SELDI-TOF/MS. We constructed an...
Administration of a choline-deficient, l-amino acid-defined (CDAA) diet to rats causes steatohepatitis, hepatic fibrosis, and hepatocellular carcinoma, pathology similar that observed in non-alcoholic steatohepatitis (NASH). The aim this study was evaluate if peroxisome proliferator-activated receptor (PPAR)-gamma agonist, pioglitazone (PGZ), could ameliorate CDAA diet-induced fatty liver cirrhosis. Rats were fed for 1 week given the an additional with or without PGZ (2-week model). Also,...
Abstract Background: Hepatocyte growth factor (HGF) is the primary agent promoting proliferation of mature hepatocytes. The purpose present paper was to clarify effects HGF on and differentiation hepatic oval cells using a 2‐acetylaminofluorene/partial hepatectomy (2‐AAF/PH) model in rats. Methods: Recombinant human (0.2 mg/day) administered 2‐AAF/PH rats for 7 days osmotic pumps intraperitoneally implanted conjunction with (day zero). Results: Periportal basophilic areas consisting were...
Abstract Hepatitis C virus (HCV) reactivation has been reported to be caused due several anticancer drugs and immunosuppressive agents; however, HCV after steroid monotherapy rarely reported. Here, we report the case of a 65-year-old Japanese man with infection who developed administration prednisolone (PSL) for 6 days sudden deafness. In patient history, positivity anti-HCV antibody was observed, but serum level RNA not measured. Two months PSL administration, experienced an alanine...
A 15-year-old girl presented with acute hepatic failure showing ascites and encephalopathy, accompanied by hemolytic anemia. She was diagnosed as having fulminant Wilson's disease (FWD). Plasma exchange (PE), continuous hemodiafiltration (CHDF) D-penicillamine administration were started immediately. Copper [24, 000 μg] removed PE CHDF over three days, which relieved the jaundice consciousness disorder. successful liver transplant followed. FWD progresses rapidly often transplantation is...
Hepatocyte growth factor (HGF) stimulates liver regeneration and has the potential to be a therapeutic agent for fatal diseases, including fulminant hepatic failure cirrhosis . In this study, we investigated pharmacokinetics of recombinant human HGF, which will soon available clinical applications. When HGF (0.1 mg/kg) was administered intravenously normal rats, serum levels increased 89.7 ± 20.6 ng/ml 5 min after bolus injection, followed by decrease with half-life 2.4 min. Recombinant...
Ten-eleven translocation-2 (TET2) mutation is frequently observed in myeloid malignancies, and loss-of-function of TET2 essential for the initiation malignant hematopoiesis. presents across disease entities was reported lymphoid malignancies. We investigated mutations 27 diffuse large B-cell lymphoma (DLBCL) patients found a frameshift 1 case (3.7%). occurred some populations DLBCL likely involved pathogenesis their
Loss-of-function of ten-eleven translocation-2 (TET2) is a common event in myeloid malignancies, and plays pleiotropic roles, including augmenting stem cell self-renewal skewing hematopoietic cells to the lineage. TET2 mutation has also been reported lymphoid malignancies; 5.7～12% diffuse large B-cell lymphomas 18～83% angioimmunoblastic T-cell had mutations. We investigated mutations 22 adult leukemia/lymphoma (ATLL) patients identified missense 3 cases (14%). occurred number ATLL was likely...
Hepatocyte growth factor (HGF) modulates intestinal epithelial cell proliferation and migration, serving as a critical regulator of wound healing. The aim this study was to clarify the effects administration recombinant human HGF on colonic mucosal damage in vivo.Rats were given 7.5 mg 2,4,6-trinitrobenzene sulfonic acid (TNBS) per rectum day 0. On 5, degree TNBS-induced colitis evaluated endoscopically, rats suffering from large ulcers (occupying more than two thirds luminal circumference)...
Hepatocyte growth factor (HGF) is a promising agent for the treatment of liver cirrhosis because its mitogenic and anti-fibrotic effects. We investigated effect recombinant human HGF (rh-HGF) on development; pharmacokinetics nephrotoxicity in rats with induced by 4-week dimethylnitrosamine (DMN). rh-HGF (0.3 mg/kg) was intravenously administered to once day 4 weeks parallel DMN or twice last 2 treatment. Repeated doses increased weight serum albumin, reduced ALT. The development hepatic...
Abstract Calreticulin ( CALR ) exon 9 frameshift mutations, commonly detected in essential thrombocythemia (ET) and primary myelofibrosis patients, activate signal transducer activator of transcription (STAT) proteins the presence Myeloproliferative Leukemia Virus (MPL) induce ET vivo. Loss KDEL motif, an endoplasmic reticulum retention signal, generation many positively charged amino acids (AAs) mutated C-terminus are thought to be important for disease induction. To test this hypothesis,...
Progression of chronic liver fibrosis and related increased fibrotic markers are associated with functional reserves or patient prognosis as well tumor factors in hepatocellular carcinoma (HCC) patients. The aim this study was to newly clarify the relationship between HCC malignant behaviors its long-term postoperative by retrospective cohort study.