A5049499512- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Aquatic Invertebrate Ecology and Behavior
- Photosynthetic Processes and Mechanisms
- Soybean genetics and cultivation
- Algal biology and biofuel production
- Cancer, Hypoxia, and Metabolism
- Human Health and Disease
- Antioxidant Activity and Oxidative Stress
- Mollusks and Parasites Studies
- Calcium signaling and nucleotide metabolism
- Orthopaedic implants and arthroplasty
- Fungal and yeast genetics research
- Bacteriophages and microbial interactions
- RNA regulation and disease
- Toxoplasma gondii Research Studies
- ATP Synthase and ATPases Research
- RNA Research and Splicing
- Neuroblastoma Research and Treatments
- Ubiquitin and proteasome pathways
- Genomics and Chromatin Dynamics
- Genomics, phytochemicals, and oxidative stress
- Biofuel production and bioconversion
- Nuclear Materials and Properties
- RNA modifications and cancer
Austrian Academy of Sciences
2020-2025
Vienna Biocenter
2025
Gregor Mendel Institute of Molecular Plant Biology
2020-2025
Medical University of Vienna
2025
Lomonosov Moscow State University
2018-2021
Moscow State University
2019
Institute of Gene Biology
2016
Eukaryotes have evolved various quality control mechanisms to promote proteostasis in the endoplasmic reticulum (ER). Selective removal of certain ER domains via autophagy (termed as ER-phagy) has emerged a major mechanism. However, degree which ER-phagy is employed by other branches ER-quality remains largely elusive. Here, we identify cytosolic protein, C53, that specifically recruited autophagosomes during ER-stress, both plant and mammalian cells. C53 interacts with ATG8 distinct binding...
Abstract Pathogens employ sophisticated strategies to modulate host protein homeostasis by targeting proteolytic pathways, but their impact on synthesis remains elusive. We report that pathogenic bacteria Pseudomonas syringae ( Pst ) targets ribonucleoprotein condensates, known as processing bodies (P-bodies), attenuate translation through two effectors with liquid-like properties. uncovered a previously unknown link -mediated repression of the ER stress response is required for P-body...
Mitophagy, the selective degradation of mitochondria via autophagic pathway, is a vital mechanism mitochondrial quality control in cells. The removal malfunctioning or damaged essential for normal cellular physiology and tissue development. Stimulation permeabilization release proapoptotic factors from intermembrane space an step triggering pathway cell death. In this study, we analyzed extent to which mitophagy interferes with death, attenuating efficiency cancer therapy. We show that...
The dependence of tumors on glycolysis for ATP generation offers a rationale therapeutic strategies aimed at selective inhibition the glycolytic pathway. Analysis tumor cell responses to anticancer drugs revealed that by 2‐deoxy‐D‐glucose (2‐ DG ) generally augmented apoptotic response; however, in HCT 116 human colon carcinoma cells, apoptosis was suppressed. A comparison neuroblastoma SK ‐N‐ BE (2) and cells revealed, contrast 116, 2‐ alone able induce death. In decrease levels upon...
To counteract oxidative stress, antioxidants including carotenoids are highly promising, yet their exploitation is drastically limited by the poor bioavailability and fast photodestruction, whereas current delivery systems far from being efficient. Here we demonstrate that recently discovered nanometer-sized water-soluble carotenoprotein Anabaena sp. PCC 7120 (termed AnaCTDH) transiently interacts with liposomes to efficiently extract via carotenoid-mediated homodimerization, yielding...
Targeting mitochondria with thenoyltrifluoroacetone (TTFA), an inhibitor of Complex II in the respiratory chain, stimulated cisplatin-induced apoptosis various cell lines normoxia but not hypoxia. This can be explained by elimination involved triggering apoptotic death mitophagy, either Parkin-dependent or receptor-mediated. Treatment TTFA alone combination cisplatin did cause accumulation PINK1, meaning that under hypoxic conditions cells survive through activation a receptor-mediated...
The majority of anticancer drugs are DNA-damaging agents, and whether or not they may directly target mitochondria remains unclear. In addition, tumors such as neuroblastoma exhibit addiction to glutamine in spite it being a nonessential amino acid. Our aim was evaluate the direct effect widely used on mitochondrial activity combination with withdrawal, possible apoptotic effects interaction. results revealed that etoposide inhibits respiratory chain Complex I causing leakage electrons...
Abstract Selective autophagy is a fundamental protein quality control pathway that safeguards proteostasis by degrading damaged or surplus cellular components, particularly under stress. This process orchestrated selective receptors (SARs) direct specific cargo for degradation. While significant strides have been made in understanding the molecular framework of autophagy, diversity SAR repertoires across species remain largely unexplored. Through comparative interactome analysis five model...
Abstract Taxonomy of freshwater mussels from family Unionidae has been ambiguous for a long time. A number methods used their identification, including the so-called comparative method, are based on shell morphology. However, this morphology turned out to have high level within-species variation, and shape specimen depends strongly its environment conditions growth. For these reasons, species recognized by method kept increasing. We applied both morphological molecular genetics address...
Abstract To counteract oxidative stress, antioxidants including carotenoids are highly promising, yet their exploitation is drastically limited by the poor bioavailability and fast photodestruction, whereas current delivery systems far from being efficient. Here we demonstrate that recently discovered nanometer-sized water-soluble carotenoprotein Anabaena (termed CTDH) transiently interacts with liposomes to efficiently extract via carotenoid-mediated homodimerization, yielding violet-purple...
Summary Eukaryotes have evolved various quality control mechanisms to promote proteostasis in the ER. Selective removal of certain ER domains via autophagy (termed as ER-phagy) has emerged a major mechanism. However, degree which ER-phagy is employed by other branches ER-quality remains largely elusive. Here, we identify cytosolic protein, C53, that specifically recruited autophagosomes during ER-stress, both plant and mammalian cells. C53 interacts with ATG8 distinct binding epitope,...