A5101652888- Immune cells in cancer
- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Synthesis and Catalytic Reactions
- Immune responses and vaccinations
- Cyclopropane Reaction Mechanisms
- Immunotherapy and Immune Responses
- Advanced Biosensing Techniques and Applications
- Single-cell and spatial transcriptomics
- Catalytic C–H Functionalization Methods
- Endoplasmic Reticulum Stress and Disease
- Glycosylation and Glycoproteins Research
- Advancements in Transdermal Drug Delivery
- Plant Molecular Biology Research
- Proteoglycans and glycosaminoglycans research
- Biosensors and Analytical Detection
- Mosquito-borne diseases and control
- DNA Repair Mechanisms
- Phagocytosis and Immune Regulation
- Circadian rhythm and melatonin
- Colorectal Cancer Treatments and Studies
- Plant biochemistry and biosynthesis
- Cancer Treatment and Pharmacology
- Chemokine receptors and signaling
- Plant Gene Expression Analysis
National Yang Ming Chiao Tung University
2021-2023
National Tsing Hua University
2023
Agricultural Biotechnology Research Center, Academia Sinica
2015-2022
National Health Research Institutes
2021-2022
Czech Academy of Sciences, Institute of Microbiology
2022
Institute of Biomedical Sciences, Academia Sinica
2022
Microneedle (MN) patches, which allow the extraction of skin interstitial fluid (ISF) without a pain sensation, are powerful tools for minimally invasive biofluid sampling. Herein, an MN-assisted paper-based sensing platform that enables rapid and painless analysis with ultrasensitive molecular recognition capacity is developed. First, controllable-swelling MN patch constructed through engineering poly(ethylene glycol) diacrylate/methacrylated hyaluronic acid hydrogel; it combines rapid,...
Tissue-resident macrophages are essential to protect from pathogen invasion and maintain organ homeostasis. The ability of thymic engulf apoptotic thymocytes is well appreciated, but little known about their ontogeny, maintenance, diversity. Here, we characterized the surface phenotype transcriptional profile these cells defined expression signature. Thymic were most closely related spleen red pulp Kupffer shared transcription factor (TF) SpiC with cells. Single-cell RNA sequencing...
Abstract Background Colorectal cancer (CRC), the most common type, causes high morbidity and mortality. Patients who develop drug resistance to oxaliplatin-based regimens have short overall survival. Thus, identifying molecules involved in development of oxaliplatin is critical for designing therapeutic strategies. Methods A proteomic screen was performed reveal altered protein kinase phosphorylation oxaliplatin-resistant (OR) CRC tumour spheroids. The function CHK2 characterised using...
A rhodium(III)-catalyzed controllable [4 + 1] and 2] annulation of N-aryl pyrazolones with maleimides as C1 C2 synthon has been explored for the synthesis spiro[pyrazolo[1,2-a]indazole-pyrrolidines] fused pyrazolopyrrolo cinnolines. The product selectivity was achieved through time-dependent annulation. reaction involves sequential Rh(III)-catalyzed C-H alkenylation pyrazolone, followed by an intramolecular spirocyclization via aza-Michael-type addition to afford...
Tissue-resident macrophages (TRMs) are heterogeneous cell populations found throughout the body. Depending on their location, they perform diverse functions maintaining tissue homeostasis and providing immune surveillance. To survive function within, TRMs adapt metabolically to distinct microenvironments. However, little is known about metabolic signatures of TRMs. The thymus provides a nurturing milieu for developing thymocytes yet efficiently removes those that fail selection, relying...
Ocular adverse events are common dose-limiting toxicities in cancer patients treated with HSP90 inhibitors, such as AUY922; however, the pathology and molecular mechanisms that mediate AUY922-induced retinal toxicity remain undescribed.The impact of AUY922 on mouse retinas cell lines was comprehensively investigated using isobaric tags for relative absolute quantitation (iTRAQ)‑based proteomic profiling pathway enrichment analysis, immunohistochemistry immunofluorescence staining, terminal...
Abstract An efficient synthesis of novel dinitrogen‐fused heterocycles such as pyrazolo[1,2‐ a ]cinnoline derivatives have been accomplished by the rhodium(III)‐catalyzed reaction N ‐arylpyrazol‐5‐ones with α ‐diazo compounds. This proceeds through cascade C−H activation/intramolecular cyclization broad substrate scope. Furthermore, this protocol is successfully extended to unusual phosphorus‐containing compounds and cyclic diazo cross‐coupling partners deliver two new kinds ]cinnolinones....
Thymus organogenesis and T cell development are coordinated by various soluble cell-bound molecules. Heparan sulfate (HS) proteoglycans can interact with immobilize many mediators, creating fields or gradients of secreted ligands. While the role HS in organs has been studied extensively, little is known about its function thymus. Here, we examined distribution thymus effect absence on development. We found that was expressed most abundantly thymic fibroblasts at lower levels endothelial,...
Aurones belong to a small class of flavonoids that provide yellow color in some floricultural plants including snapdragon. To explore novel flower coloration, two full-length cDNAs encoding chalcone 4'-O-glucosyltransferase (designated as SRY4'CGT) and aureusidin synthase SRYAS1) the aurone biosynthetic pathway were cloned from flowers snapdragon (Antirrhinum majus cv. Ribbon Yellow). Binary vectors constructed transformed separately into Petunia hybrida harboring blue flowers. Only few 4...
Abstract Tissue-resident macrophages are essential to protect from pathogen invasion and maintain organ homeostasis. The ability of thymic engulf apoptotic thymocytes is well appreciated, but little known about their ontogeny, maintenance, diversity. Here, we characterized the surface phenotype transcriptional profile these cells defined expression signature. Thymic were most closely related spleen red pulp Kupffer shared transcription factor SpiC with cells. Single-cell RNA sequencing...