A5067143169- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- DNA Repair Mechanisms
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related Molecular Pathways
- Lung Cancer Research Studies
- Cancer Research and Treatments
- Advanced Breast Cancer Therapies
- Cancer-related molecular mechanisms research
- Fibroblast Growth Factor Research
- Cancer Mechanisms and Therapy
- Histone Deacetylase Inhibitors Research
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
National Cheng Kung University Hospital
2018-2025
National Health Research Institutes
2014-2025
Chi Mei Medical Center
2012-2021
National Cheng Kung University
2013-2017
BIRC5/Survivin is known as a dual cellular functions protein that directly regulates both apoptosis and mitosis in embryonic cells during embryogenesis cancer tumorigenesis tumor metastasis. However, BIRC5 has seldom been demonstrated direct macroautophagy/autophagy regulator cells. ATG7 expression ATG12–ATG5-ATG16L1 complex formation are crucial for the phagophore elongation autophagy mammalian In this study, we observed levels of were inversely correlated, whereas SQSTM1/p62 positively...
SAHA is a class I HDAC/HDAC6 co-inhibitor and an autophagy inducer currently undergoing clinical investigations in breast cancer patients. However, the molecular mechanism of action cells remains unclear. In this study, we found that equally effective targeting different subtypes tamoxifen sensitivity. Importantly, down-regulation survivin plays important role SAHA-induced cell viability reduction human cells. decreased XIAP gene transcription, induced protein acetylation early nuclear...
Acquired resistance to endocrine therapy is a major clinical challenge in the treatment of luminal A [estrogen receptor (ER)+ and/or progesterone (PR)+, human epidermal growth factor 2 (ERBB2/HER2)-, and low Ki-67] breast cancer. Recently, molecular subtype conversion has been suggested as one possible causes development drug-resistant However, mechanism underlying induction cancer still incompletely understood. Here, we found that ER+ MCF7-derived therapy-resistant MCF7-TamC3 cells exhibit...
Abstract Background Colorectal cancer (CRC), the most common type, causes high morbidity and mortality. Patients who develop drug resistance to oxaliplatin-based regimens have short overall survival. Thus, identifying molecules involved in development of oxaliplatin is critical for designing therapeutic strategies. Methods A proteomic screen was performed reveal altered protein kinase phosphorylation oxaliplatin-resistant (OR) CRC tumour spheroids. The function CHK2 characterised using...
Lymph node and distant metastasis contribute to poor outcomes in patients with oral squamous cell carcinoma (OSCC). The mechanisms regulating cancer migration invasion play a key role OSCC.We determined ability of OSCC by wound-healing assay, two-chamber transwell assay mobility tracking evaluated tumor vivo. Western blot (WB), qRT-PCR, RNA-seq, dual-luciferase reporter assays nuclear/cytoplasmic fractionation were performed investigate the potential mechanism. Immunohistochimical (IHC)...
Abstract Background Cancer susceptibility germline mutations are associated with pancreatic ductal adenocarcinoma (PDAC). However, the hereditary status of PDAC and its impact on survival is largely unknown in Asian population. Methods Exome sequencing was performed 527 blood samples from individuals analyzed for 80 oncogenic genes. Pathogenic likely pathogenic (P/LP) variants were diagnosed according to ACMG variant classification categories. The association between homologous recombination...
The S-phase kinase-associated protein 2 (SKP2) oncoprotein is an E3 ubiquitin ligase. Overexpression of SKP2 was found in various human cancers, including colorectal but its potential role as a prognostic marker after neoadjuvant chemoradiotherapy (CRT) and for therapeutic intervention rectal cancers unknown. This study examined the correlation expression prognosis cancer patients viability cells treated with CRT. immunoexpression retrospectively assessed pretreatment biopsies 172 CRT...
Intrinsic or acquired resistance to hormone therapy is frequently reported in estrogen receptor positive (ER+) breast cancer patients. Even though dysregulations of histone deacetylases (HDACs) are known promote cells survival, the role different HDACs induction ER+ remains unclear. Survivin a well-known pro-tumor survival molecule and miR-125a-5p recently discovered tumor suppressor. In this study, we found that ER+, hormone-independent, tamoxifen-resistant MCF7-TamC3 exhibit increased...
Abstract Background The homologous recombination (HR) pathway is involved in DNA damage response (DDR), which crucial to cancer cell survival after treatment with agents. O6-methylguanine methyltransferase (MGMT) associated cisplatin (CDDP) resistance cells; however, the underlying mechanisms remain unclear. Here, we explored interactions between MGMT and HR CDDP-activated DDR their clinical implications nasopharyngeal carcinoma (NPC). Methods Human NPC cells were assessed using...
// Jinn-Yuan Hsu 1 , Kwang-Yu Chang 2 Shang-Hung Chen 3 Chung-Ta Lee 4 Sheng-Tsung 5 Hung-Chi Cheng 6 Wen-Chang 7 Ben-Kuen 7, 8, 9 Institute of Basic Medical Sciences, College Medicine, National Kung University, Tainan 701, Taiwan, ROC Cancer Research, Health Research Institutes and Division Hematology/Oncology, Department Internal Hematology Oncology, Chi-Mei Center, Liouying, 736, Pathology, University Hospital, 710, Biochemistry, Graduate Taipei 110, 8 Pharmacology, Bioinformatics...
Programmed death-ligand 1 (PD-L1) is an immune checkpoint molecule that can regulate responses in the tumor microenvironment (TME); however, clinical applications of PD-L1 early-stage colorectal cancer (CRC) remain unclear. In this study, we aimed to investigate relationship between expression and survival outcome explore its relevant CRC. was evaluated by immunohistochemical staining determine proportion score combined positive (CPS) a Taiwanese CRC cohort. The oncomine response research...
Aims Neoadjuvant chemoradiation therapy (CRT) is an increasingly used therapeutic strategy for rectal cancer. Clinically, it remains a major challenge to predict response and patient outcome after CRT. Rsf-1 (HBXAP), novel nuclear protein with histone chaperon function, mediates ATPase-dependent chromatin remodelling confers tumour aggressiveness predicts in certain carcinomas. However, the expression of has never been reported This study examined predictive prognostic impacts patients...
Aims Neoadjuvant concurrent chemoradiotherapy (CCRT) followed by surgery is an increasingly used therapeutic strategy for advanced rectal cancer, but risk stratification and final outcomes remain suboptimal. Recently, the oncogenic role of fibroblast growth factor/fibroblast factor receptor (FGFR) signalling pathway has been recognised; however, its clinical significance in cancer not elucidated. In this study, we identify validate targetable drivers associated with FGFR patients treated...
TPS7614 Background: First-line erlotinib (an EGFR tyrosine-kinase inhibitor) significantly increased progression-free survival (PFS) vs chemotherapy in phase III trials of pts with mutation-positive NSCLC. Discontinuation on RECIST disease progression (PD) may lead to rapid flare-up; continued beyond PD extend clinical benefit by slowing this life-threatening disease. We describe ASPIRATION, a large, Asian, multicenter, single-arm, open-label, II trial (NCT01310036), which will increase...
Locally advanced rectal cancers are currently treated with neoadjuvant concurrent chemoradiotherapy (CCRT) followed by surgery, but risk stratification and final outcomes remain suboptimal. In this study, we identify validate targetable metabolic drivers relevant to the prognosis of patients cancer CCRT. Using a published transcriptome cancers, found that asparagine synthetase (ASNS) gene significantly predicted response From 172 cancer, expression levels ASNS, using immunohistochemistry...
The mechanism by which glioblastoma evades temozolomide (TMZ)-induced cytotoxicity is largely unknown. We hypothesized that mitochondria plays a role in this process. RNA transcriptomes were obtained from tumor samples and online databases. Expression of different proteins was manipulated using interference or gene amplification. Autophagic activity mitochondrial metabolism assessed vitro the respective cellular molecular assays. In vivo analysis also carried out study. High SH3GLB1...
Colorectal cancer (CRC) is one of the most prevalent malignant diseases worldwide. Risk prediction for tumor recurrence important making effective treatment decisions and survival outcomes patients with CRC after surgery. Herein, we aimed to explore a algorithm risk factors postoperative using machine learning (ML) approach standardized pathology reports stage II III CRC. Pertinent clinicopathological features were compiled from medical records Four ML models based on logistic regression...
Immune checkpoint inhibitors (ICIs) combined with multitarget tyrosine kinase (MTKIs) exert a synergistic effect and are effective in unresectable hepatocellular carcinoma (uHCC). However, precise data regarding the real-world clinical applications of these combination therapies uHCC lacking. This study compared treatment efficacy sorafenib versus lenvatinib programmed cell death protein-1 (PD-1) patients setting. Among 208 treated PD-1 inhibitors, 88 were administered ICIs or lenvatinib....
The oncologic merits of the laparoscopic technique for colorectal cancer surgery remain debatable. Eligible patients with non-metastatic who were scheduled an elective resection by one surgeon in a medical institution randomized to either or open surgery. During this period, total 188 received and other 163 approach. primary endpoint was cancer-free five-year survival after operative treatment, secondary tumor recurrence incidence. Besides, surgical complications also compared. There no...
Background: Concurrent chemoradiotherapy (CCRT) has now become the standard of treatments for advanced rectal cancer before surgery. To search biological molecules with prognostic and therapeutic potential CCRT could be beneficial these patients. Recently, aberrant expression chloride channels been linked to radio-resistance in glioblastoma; however, its clinical implication not well-studied cancers. Therefore, we examined significance targetable drivers associated channel activity patients...