A5019974091- Dialysis and Renal Disease Management
- Health Systems, Economic Evaluations, Quality of Life
- Central Venous Catheters and Hemodialysis
- Muscle and Compartmental Disorders
- Acute Kidney Injury Research
- Heart Failure Treatment and Management
- Resilience and Mental Health
- Health and Wellbeing Research
- Healthcare cost, quality, practices
- Psychological Testing and Assessment
- COVID-19 and Mental Health
- Optimism, Hope, and Well-being
- Delphi Technique in Research
- Geriatric Care and Nursing Homes
- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Meta-analysis and systematic reviews
- Health and Well-being Studies
- Lipoproteins and Cardiovascular Health
- Potassium and Related Disorders
- Mental Health and Patient Involvement
- Cerebral Palsy and Movement Disorders
- Reliability and Agreement in Measurement
Fresenius Medical Care (Germany)
2018-2025
Humboldt-Universität zu Berlin
2023-2025
Charité - Universitätsmedizin Berlin
2023-2025
Freie Universität Berlin
2023-2025
Hesse (Germany)
2024
City University of Hong Kong
2012
Several studies have suggested that patients with kidney failure may benefit from high-dose hemodiafiltration as compared standard hemodialysis. However, given the limitations of various published studies, additional data are needed.
High-flux hemodialysis (HD) and high-dose hemodiafiltration (HDF) are established treatments for patients with kidney failure. Since HDF has been associated improved survival rates compared to HD, we evaluated the cost-effectiveness of HD. Cost-utility analyses were performed from a societal perspective alongside multinational randomized controlled CONVINCE trial. A Markov cohort model was used extrapolate results lifetime time horizon. Costs dialysis sessions based on published data, two...
Introduction End-stage kidney disease (ESKD) is a major public health problem affecting more than 2 million people worldwide. It one of the most severe chronic non-communicable diseases. Haemodialysis (HD) common therapeutic option but also associated with risk cardiovascular events, hospitalisation and suboptimal quality life. Over past decades, haemodiafiltration (HDF) has become available. Although high-dose HDF shown some promising survival advantage compared to conventional HD, evidence...
In the CONVINCE trial, primary analysis demonstrated a survival benefit for patients receiving high-dose hemodiafiltration (HDF) as compared with high-flux hemodialysis (HD). A secondary objective was to evaluate effects on health-related quality of life (HRQoL); assessed in eight domains (physical function, cognitive fatigue, sleep disturbance, anxiety, depression, pain interference, social participation) applying instruments from Patient-Reported Outcome Measurement Information System...
High convection volumes in hemodiafiltration (HDF) result improved survival; however, it remains unclear whether is achievable all patients.CONVINCE, a randomized controlled trial, patients with end-stage kidney disease 1:1 to high-dose HDF versus high-flux hemodialysis (HD) continuation. We evaluated the proportion of achieving target: volume per visit ≥23 l (range ±1 l) at baseline, month 3, and 6. compared baseline characteristics following 2 ways: (i) on target for 3 visits who missed ≥1...
To investigate whether a multi-item performance outcome measure, the physical test (PPT), can be calibrated to common scale with patient-reported measures, using Patient-Reported Outcomes Measurement Information System (PROMIS) function (PF) metric.We analyzed baseline data (N = 1,113) from CONVINCE study, an international trial in end-stage kidney disease patients comparing high-dose hemodiafiltration high-flux hemodialysis. Assumptions of item response theory (IRT) modelling were...
Abstract Background and Aims Health-related quality of life ESKD patients is negatively affected by disease-specific symptoms can additionally be impaired renal replacement therapy. Previous studies indicate that hemodiafiltration (HDF) may have a positive impact on the patients’ perceived health status compared to hemodialysis (HD), but overall evidence has been inconclusive. We investigated whether HDF beneficial with respect in CONVINCE Trial. Method The Trial an international...
Leading young researchers describe their current patient-centred research from epidemiological, immunological and psychological perspectives Schedule: 1. 13:30-14:00 Dialysis After Graft Loss - Survival Factors 2. 14:00-14:30 Immune Injury 3. 14:30-15:00 Patient Related Outcomes with Haemodiafiltration Kidney transplant failure contributes to a considerable proportion of new dialysis starters. In some centres there are dedicated clinics for patients failing kidney transplants, however, the...
Abstract Background and Aims Patient-centered outcomes play an important role when assessing treatment effects. Patient-reported outcome (PRO) measures symptoms impacts are tools to capture the patient perspective in clinical trials. However, careful consideration is needed choosing PROs PRO measures. Aspects such as conceptual model, measurement validity, reliability, responsiveness, well translation, interpretability of scores burden for participants investigators have be considered...
Abstract Background and Aims In nephrology, there is a growing interest in identifying patients’ priorities to achieve meaningful outcomes. A particular relevant outcome end stage kidney disease fatigue, with prevalence ranging from 60% 97% patients receiving hemodialysis. Different approaches for assessing fatigue exist. The objective of this study was investigate how self-reported peri-/intra-dialytic post-dialysis relate overall levels certain risk factors Method CONVINCE trial an...
Abstract Background and Aims Patients on hemodialysis (HD) experience a wide range of symptoms during between dialysis that negatively affect their well-being. Addressing these symptoms, particularly from the patient's perspective, is crucial component in treatment. Our findings suggest beneficial effect hemodiafiltration (HDF) over mortality quality life. This study aimed to investigate differences symptom severity patients HD HDF. Method Patient-reported outcomes data 1264 were extracted...
Abstract Background and Aims The generalizability of randomized controlled trials (RCTs) results is based on representativeness the population involved. Trial populations may have different baseline characteristics compared to general that could benefit from intervention. We compare patients involved in CONVINCE trial with those all previous RCTs representative registries receiving hemodialysis as renal replacement therapy. Method Based world class methods for systematic reviews, we...
Abstract Background and Aims Patients with kidney disease receiving dialysis are a highly vulnerable population. Psychosocial determinants of Self-Efficacy (SE) Social Support (SS) have been suggested as potentially important outcomes for people end stage disease. We investigated whether these variables could explain differences in Health-Related Quality Life (HRQL) outcome domains over time independently or interaction treatment modality high-flux hemodialysis (HD) versus high-dose...
Abstract Background and Aims Physical function is a crucial outcome in nephrology. In alignment with the Patient-Reported Outcomes Measurement Information System (PROMIS) Initiative, physical characterized as ability to execute activities involving actions, ranging from self-care more complex activities, such social activities. This definition of spans various domains International Classification Functioning, Health, Disability (ICF). The assessment commonly employs two distinct approaches,...
We applied a previously established common T-score metric for patient-reported and performance-based physical function (PF), offering the unique opportunity to directly compare measurement type-specific patterns of associations with potential laboratory-based, psychosocial, sociodemographic, health-related determinants in hemodialysis patients.
Background: We investigated whether psychosocial determinants self-efficacy and social support are associated with Health-Related Quality of Life in hemodialysis patients enrolled the CONVINCE trial. Methods: used baseline data from cohort involved randomized trial hemodiafiltration versus hemodialysis. Measures included age, gender, relationship status, children, housing, education, employment, comorbidities, dialysis schedules, time first dialysis, residual kidney function, general scores,...