Andrea A. Guerrero
A5072095897- Protein Structure and Dynamics
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Intracranial Aneurysms: Treatment and Complications
- Venous Thromboembolism Diagnosis and Management
- Lymphatic System and Diseases
- Congenital heart defects research
- Neuroscience and Neuropharmacology Research
- Cellular transport and secretion
- Acute Myocardial Infarction Research
- Vascular Malformations Diagnosis and Treatment
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Intracerebral and Subarachnoid Hemorrhage Research
Brandeis University
2022
Cardiovascular Institute Hospital
2021
University of Pennsylvania
2020
In recent decades, treatments for myocardial infarction (MI), such as stem and progenitor cell therapy, have attracted considerable scientific clinical attention but failed to improve patient outcomes. These efforts indicate that more rigorous mechanistic functional testing of potential MI therapies is required. Recent studies suggested augmenting post-MI lymphatic growth via VEGF-C administration improves cardiac function. However, the mechanisms underlying this proposed therapeutic...
Cerebral cavernous malformations (CCMs) form following loss of the CCM protein complex in brain endothelial cells due to increased MEKK3 signaling and KLF2/4 transcription factor expression, but downstream events that drive lesion formation remain undefined. Recent studies have revealed lesions expand by incorporating neighboring wild-type cells, indicative a cell nonautonomous mechanism. Here we find ADAMTS5 reduced neonatal mouse model. Conversely, gain conferred early genesis absence...
Homeostatic synaptic plasticity requires widespread remodeling of signaling and scaffolding networks, but the role post-translational modifications in this process has not been systematically studied. Using deep-scale quantitative analysis phosphoproteome mouse neocortical neurons, we found temporally complex changes during scaling up down. We observed 424 bidirectionally modulated phosphosites that were strongly enriched for synapse-associated proteins, including S1539 autism spectrum...
Abstract Background and Aims It has been reported that patients without standard modifiable cardiovascular (CV) risk factors (SMuRFs—diabetes, dyslipidaemia, hypertension, smoking) presenting with first myocardial infarction (MI), especially women, have a higher in-hospital mortality than factors, possibly lower long-term provided they survive the post-infarct period. This study aims to explore outcomes of SMuRF-less stable coronary artery disease (CAD). Methods CLARIFY is an observational...